Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Paola Misiano"'
Autor:
Nicoletta Basilico, Silvia Parapini, Sarah D’Alessandro, Paola Misiano, Sergio Romeo, Giulio Dondio, Vanessa Yardley, Livia Vivas, Shereen Nasser, Laurent Rénia, Bruce M. Russell, Rossarin Suwanarusk, François Nosten, Anna Sparatore, Donatella Taramelli
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 836 (2023)
The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are still commonly used for malaria treatment, either alone (CQ) or in combination with artemisinin derivatives. We previously described the excellent in vitro activity
Externí odkaz:
https://doaj.org/article/fe1997e4bed24f56a94dd9fe831661dd
Autor:
Yolanda Corbett, Silvia Parapini, Federica Perego, Valeria Messina, Serena Delbue, Paola Misiano, Mario Falchi, Francesco Silvestrini, Donatella Taramelli, Nicoletta Basilico, Sarah D’Alessandro
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Abstract Background The innate immune response against various life cycle stages of the malaria parasite plays an important role in protection against the disease and regulation of its severity. Phagocytosis of asexual erythrocytic stages is well doc
Externí odkaz:
https://doaj.org/article/fe02e78e240a4d3da01e9f7ca157949c
Autor:
Yuet Wu, Silvia Parapini, Ian D. Williams, Paola Misiano, Ho Ning Wong, Donatella Taramelli, Nicoletta Basilico, Richard K. Haynes
Publikováno v:
Molecules, Vol 23, Iss 7, p 1713 (2018)
According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we
Externí odkaz:
https://doaj.org/article/b517221cd3f7487bac373f6cbbd2101b
Autor:
Nicoletta Basilico, Silvia Parapini, Anna Sparatore, Sergio Romeo, Paola Misiano, Livia Vivas, Vanessa Yardley, Simon L. Croft, Annette Habluetzel, Leonardo Lucantoni, Laurent Renia, Bruce Russell, Rossarin Suwanarusk, Francois Nosten, Giulio Dondio, Chiara Bigogno, Daniela Jabes, Donatella Taramelli
Publikováno v:
Molecules, Vol 22, Iss 12, p 2102 (2017)
Natural products are a prolific source for the identification of new biologically active compounds. In the present work, we studied the in vitro and in vivo antimalarial efficacy and ADME-Tox profile of a molecular hybrid (AM1) between 4-aminoquinoli
Externí odkaz:
https://doaj.org/article/109aa3a57b6d49ebb3938d568b370008
Autor:
Sarah D'Alessandro, D. Ilboudo, Nicoletta Basilico, Paola Misiano, Donatella Taramelli, Estefanía Calvo Alvarez, Silvia Parapini
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 113:107134
Erythropoiesis is a complex physiological process by which erythroid progenitors proliferate and differentiate into nonnucleated red blood cells. Several methods can be used to monitor in vitro the differentiation of erythroid precursors, and hence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a81ac06019e507dec38b855019558f
https://doi.org/10.1016/j.vascn.2021.107134
https://doi.org/10.1016/j.vascn.2021.107134
Autor:
Sarah D'Alessandro, Yolanda Corbett, Paola Misiano, Silvia Parapini, Nicoletta Basilico, Francesco Silvestrini, Donatella Taramelli, Serena Delbue, Mario Falchi, Federica Perego, Valeria Messina
Publikováno v:
Malaria Journal
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Malaria Journal, Vol 20, Iss 1, Pp 1-10 (2021)
Background The innate immune response against various life cycle stages of the malaria parasite plays an important role in protection against the disease and regulation of its severity. Phagocytosis of asexual erythrocytic stages is well documented,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7c4017511ed174e479f0a334043133
https://pubmed.ncbi.nlm.nih.gov/33568138
https://pubmed.ncbi.nlm.nih.gov/33568138
Autor:
Ian D. Williams, Nicoletta Basilico, Ho Ning Wong, Richard K. Haynes, Paola Misiano, Yuet Wu, Silvia Parapini, Donatella Taramelli
Publikováno v:
Molecules
Volume 23
Issue 7
Molecules, Vol 23, Iss 7, p 1713 (2018)
Volume 23
Issue 7
Molecules, Vol 23, Iss 7, p 1713 (2018)
According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592c1ab9d113c2be0fb77b9da9639d45
Autor:
Yuet, Wu, Silvia, Parapini, Ian D, Williams, Paola, Misiano, Ho Ning, Wong, Donatella, Taramelli, Nicoletta, Basilico, Richard K, Haynes
Publikováno v:
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75329aedd9359d3a81be04958980d639
https://pubmed.ncbi.nlm.nih.gov/30011856
https://pubmed.ncbi.nlm.nih.gov/30011856
Autor:
Yolanda Corbett, Silvia Parapini, Nicoletta Basilico, Solomon M Abay, Donatella Taramelli, Koen J. Dechering, Paola Misiano, Romualdo Grande, Annette Habluetzel, Karin M. J. Koolen, Maria Rita Gismondo, Nisha Dahiya, Robert W. Sauerwein, Sarah D'Alessandro, D. Ilboudo
Publikováno v:
Antimicrobial Agents and Chemotherapy, 59, 9, pp. 5135-44
Antimicrobial Agents and Chemotherapy, 59, 5135-44
Antimicrobial Agents and Chemotherapy, 59, 5135-44
The drug target profile proposed by the Medicines for Malaria Venture for a malaria elimination/eradication policy focuses on molecules active on both asexual and sexual stages of Plasmodium , thus with both curative and transmission-blocking activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7002e30a92a28271fb400cf2552665
https://doi.org/10.1128/aac.04332-14
https://doi.org/10.1128/aac.04332-14
Autor:
Nicoletta Basilico, Yolanda Corbett, Mauro Prato, Paola Misiano, Daniela Girelli, Piero Olliaro, Donatella Taramelli, Sarah D' Alessandro, Silvia Parapini
Publikováno v:
Acta tropica. 172
Severe falciparum malaria is characterized by the sequestration of infected erythrocytes and leukocyte recruitment in the microvasculature, resulting in impaired blood flow and metabolic disturbances. Which parasite products cause chemokine productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e97bd6047451d55ada25596d2185488
https://pubmed.ncbi.nlm.nih.gov/28476599
https://pubmed.ncbi.nlm.nih.gov/28476599