Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Paola Massimi"'
Autor:
Om Basukala, Oscar Trejo-Cerro, Michael P. Myers, David Pim, Paola Massimi, Miranda Thomas, Corrado Guarnaccia, David Owen, Lawrence Banks
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Human papillomavirus (HPV) E7 plays a major role in HPV-induced malignancy, perturbing cell cycle regulation, and driving cell proliferation. Major targets of cancer-causing HPV E7 proteins are the pRB family of tumor suppressors, which E7 t
Externí odkaz:
https://doaj.org/article/cd410896bdd14c36b695b37adea5e0f0
Autor:
Ailyn C. Ramón, Om Basukala, Paola Massimi, Miranda Thomas, Yasser Perera, Lawrence. Banks, Silvio E. Perea
Publikováno v:
Viruses, Vol 14, Iss 8, p 1681 (2022)
CIGB-300 is a clinical-grade anti-Protein Kinase CK2 peptide, binding both its substrate’s phospho-acceptor site and the CK2α catalytic subunit. The cyclic p15 inhibitory domain of CIGB-300 was initially selected in a phage display library screen
Externí odkaz:
https://doaj.org/article/5907659143764cceab46157154a00537
Autor:
Christian Kranjec, Vjekoslav Tomaić, Paola Massimi, Lietta Nicolaides, John Doorbar, Lawrence Banks
Publikováno v:
Papillomavirus Research, Vol 2, Iss , Pp 70-77 (2016)
The ability of high-risk HPV E6 oncoproteins to target cellular proteins which harbor PDZ domains is believed to play an important role in the virus life cycle and to influence the ability of these viruses to bring about malignant transformation. Whi
Externí odkaz:
https://doaj.org/article/a0ac8ceee9244cb89ecdbb53dce1c500
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007769 (2019)
The Human Papillomavirus E7 oncoprotein plays an essential role in the development and maintenance of malignancy, which it achieves through targeting a number of critical cell control pathways. An important element in the ability of E7 to contribute
Externí odkaz:
https://doaj.org/article/f1e6c3732f794293b9e3b1ea64babdff
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Previous studies have shown that the endoplasmic reticulum (ER)-anchored protein VAP is strictly required by human papillomavirus type 16 (HPV-16) for successful infectious entry. Entry appeared to be mediated in part through the induction of endosom
Externí odkaz:
https://doaj.org/article/bcc19f10587a482ebf012795d7ce06dd
Autor:
Ketaki Ganti, Justyna Broniarczyk, Wiem Manoubi, Paola Massimi, Suruchi Mittal, David Pim, Anita Szalmas, Jayashree Thatte, Miranda Thomas, Vjekoslav Tomaić, Lawrence Banks
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 3530-3551 (2015)
Cancer-causing HPV E6 oncoproteins are characterized by the presence of a PDZ binding motif (PBM) at their extreme carboxy terminus. It was long thought that this region of E6 had a sole function to confer interaction with a defined set of cellular s
Externí odkaz:
https://doaj.org/article/028d97401366449fb303d6059bd08eff
Autor:
Ketaki Ganti, Paola Massimi, Joaquin Manzo-Merino, Vjekoslav Tomaić, David Pim, Martin P Playford, Marcela Lizano, Sally Roberts, Christian Kranjec, John Doorbar, Lawrence Banks
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005854 (2016)
A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents of a large number of human cancers, of which cervical is the most common. Two viral oncoproteins, E6 and E7, contribute directly towards the development and maintenance of m
Externí odkaz:
https://doaj.org/article/18b738b8e2334f26835e0e89c7a86bf5
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005766 (2016)
The high-risk Human Papillomavirus (HPV) E6 oncoproteins are characterised by the presence of a class I PDZ-binding motif (PBM) on their extreme carboxy termini. The PBM is present on the E6 proteins derived from all cancer-causing HPV types, but can
Externí odkaz:
https://doaj.org/article/fe458924358646d9ba4fd3f76de69f24
Autor:
Kazunori Nagasaka, Takayuki Seiki, Aki Yamashita, Paola Massimi, Vanitha Krishna Subbaiah, Miranda Thomas, Christian Kranjec, Kei Kawana, Shunsuke Nakagawa, Tetsu Yano, Yuji Taketani, Tomoyuki Fujii, Shiro Kozuma, Lawrence Banks
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53752 (2013)
Previous studies have shown that the cell polarity regulator hScrib interacts with, and consequently controls, the ERK signaling pathway. This interaction occurs through two well-conserved Kinase Interacting Motifs, which allow hScrib to bind ERK1 di
Externí odkaz:
https://doaj.org/article/45f0a6cc2a42441295e27e347cd5a114
Autor:
Vanitha Krishna Subbaiah, Paola Massimi, Siaw Shi Boon, Michael P Myers, Lisa Sharek, Rafael Garcia-Mata, Lawrence Banks
Publikováno v:
PLoS Pathogens, Vol 8, Iss 2, p e1002543 (2012)
A major target of the HPV E6 oncoprotein is the human Discs Large (hDlg) tumour suppressor, although how this interaction contributes to HPV-induced malignancy is still unclear. Using a proteomic approach we show that a strong interacting partner of
Externí odkaz:
https://doaj.org/article/e149b717c6e3473cb58c58cb60330248