Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paola Leon Plata"'
Autor:
Peter D Rios, Yong Wang, Colin Foster, Jose Oberholzer, Paola Leon Plata, Maryam Zaroudi, Ludwig C. Nitsche, Ying Liu, Chun-Yin Lee
Publikováno v:
Biomaterials Science. 9:3954-3967
Transplantable cell encapsulation systems present a promising approach to deliver a therapeutic solution from hormone-producing cells for the treatment of endocrine diseases like type 1 diabetes. However, the development of a broadly effective and sa
Publikováno v:
ACS Applied Bio Materials. 3:7357-7362
We report a particulate cell delivery platform, toroidal spiral particles (TSPs), for continuous cell activation, expansion, and local sustained release. Biocompatible TSPs, generated by a self-assembly process of polymeric droplet sedimentation in a
Autor:
Pin Zhang, Paola Leon Plata, Wei Bu, Binhua Lin, Tiep Pham, Anand Vellara, Ying Liu, Gang Cheng
Publikováno v:
Molecular pharmaceutics. 18(12)
Prodrugs and nanoformulations are two effective strategies for sustained drug release and targeting drug delivery. In this study, we combined the two strategies to judiciously design the liposome formulation incorporating an amphiphilic prodrug of 5-
Autor:
Chang Liu, Aiming Pang, Paola Leon Plata, Ying Liu, Can Wang, Ni Cheng, M. Keegan Delaney, Kasim K. Kabirov, Minyi Gu, Claire W Chang, Yujie Cui, Yaping Zhang, Aleksander V. Lyubimov, Asrar B. Malik, Randal A. Skidgel, Jalees Rehman, Yanyan Bai, Zhigang Hong, Xiaoping Du, Alexander Zakharov
Publikováno v:
Science Translational Medicine. 12
Inefficient delivery is a major obstacle to the development of peptide-based drugs targeting the intracellular compartment. We recently showed that selectively inhibiting integrin outside-in signaling using a peptide (mP6) derived from the Gα13-bind
Autor:
Paola Leon Plata, Xin Zheng, Ying Liu, Wei Bu, Tiep Pham, Chang Liu, Pin Zhang, Binhua Lin, Petr Král
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 193
Understanding the interaction of ions with fatty acids is important to identify their roles in various bioprocesses and to build novel biomimetic systems. In this study, the molecular organization of palmitic acid (PA) films on alkaline buffer soluti
Autor:
Ying Liu, Weifeng Shang, Pin Zhang, Paola Leon-Plata, Joseph Kalkowski, Thomas C. Irving, Chang Liu, Osman Bilsel, Magdalena Szymusiak
Publikováno v:
Macromolecules
Utilizing synchrotron small-angle X-ray scattering (SAXS) integrated with a microfluidic device, micellization kinetics of a diblock co-polymer, poly(ethylene glycol)-b-poly(caprolactone), was measured in situ with millisecond temporal and micrometer
Autor:
Aiming, Pang, Ni, Cheng, Yujie, Cui, Yanyan, Bai, Zhigang, Hong, M Keegan, Delaney, Yaping, Zhang, Claire, Chang, Can, Wang, Chang, Liu, Paola Leon, Plata, Alexander, Zakharov, Kasim, Kabirov, Jalees, Rehman, Randal A, Skidgel, Asrar B, Malik, Ying, Liu, Aleksander, Lyubimov, Minyi, Gu, Xiaoping, Du
Publikováno v:
Sci Transl Med
Inefficient delivery is a major obstacle to the development of peptide-based drugs targeting the intracellular compartment. We recently showed that selectively inhibiting integrin outside-in signaling using a peptide (mP6) derived from the Gα(13)-bi
Publikováno v:
Physics of Fluids. 33:054102
We report on the precise manipulation of the fine structures of toroidal-spiral particles (TSPs) generated by a self-assembly process of droplet sedimentation at low Reynolds numbers in a miscible bulk solution followed by solidification. The biocomp
Autor:
Paola Leon Plata, Paulina Ciupinski, Xiaoyu Hu, Magdalena Szymusiak, Ying Liu, Zaijie Jim Wang
Publikováno v:
International Journal of Pharmaceutics. 511:415-423
Curcumin is a bioactive molecule extracted from Turmeric roots that has been recognized to possess a wide variety of important biological activities. Despite its great pharmacological activities, curcumin is highly hydrophobic, which results in poor
Publikováno v:
Physical Review Fluids. 3
During sedimentation in a miscible, viscous liquid, polymeric drops self-assemble into a toroidal-spiral structure, which can be solidified by photoinitiated cross-linking. With a suitable arrangement three drops can be encapsulated, possibly enablin