Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Paola K. Párraga Solórzano"'
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The preferred carbon source of Staphylococcus aureus and many other pathogens is glucose, and its consumption is critical during infection. However, glucose utilization increases the cellular demand for manganese, a nutrient sequestered by t
Externí odkaz:
https://doaj.org/article/5d2974c0c1d144edaf231a9b7ae0a014
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT During infection, bacteria use two-component signal transduction systems to sense and adapt to the dynamic host environment. Despite critically contributing to infection, the activating signals of most of these regulators remain unknown. Thi
Externí odkaz:
https://doaj.org/article/e666c8f652c7408898634f1b3a3ecbfb
Autor:
Kyle P. Grim, Brian San Francisco, Jana N. Radin, Erin B. Brazel, Jessica L. Kelliher, Paola K. Párraga Solórzano, Philip C. Kim, Christopher A. McDevitt, Thomas E. Kehl-Fie
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT During infection, the host sequesters essential nutrients, such as zinc, to combat invading microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with subpicomolar affinity, Staphylococcus aureus is able to s
Externí odkaz:
https://doaj.org/article/8a26e45d09634efa9423ab852119bcc0
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006040 (2016)
During infection the host imposes manganese and zinc starvation on invading pathogens. Despite this, Staphylococcus aureus and other successful pathogens remain capable of causing devastating disease. However, how these invaders adapt to host-imposed
Externí odkaz:
https://doaj.org/article/b7047a69f1cf48c9a2f99135d8904540
Publikováno v:
J Bacteriol
Staphylococcus aureus is a versatile opportunistic pathogen whose success is driven by its ability to adapt to diverse environments and host-imposed stresses. Two-component signal transduction systems, such as ArlRS, often mediate these adaptations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906ffa3aadb310e77ef50babcede8a22
https://doi.org/10.1128/jb.00422-21
https://doi.org/10.1128/jb.00422-21
Autor:
Thomas E. Kehl-Fie, Jana N. Radin, Christopher A. McDevitt, Katherine Ganio, Stephanie L. Neville, Jacqueline R. Morey, Paola K. Párraga Solórzano, Kyle P. Grim, Katie A. Frye
Publikováno v:
J Bacteriol
The host restricts the availability of zinc to prevent infection. To overcome this defense, Staphylococcus aureus and Pseudomonas aeruginosa rely on zincophore-dependent zinc importers. Synthesis of the zincophore staphylopine by S. aureus and its im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a033d4bf6461dee78faefa04546c29
https://europepmc.org/articles/PMC7148132/
https://europepmc.org/articles/PMC7148132/
Autor:
Jana N. Radin, Grischa Y. Chen, Thomas E. Kehl-Fie, Lici A. Schurig-Briccio, Paola K. Párraga Solórzano, Andrea M. Lencina, Robert B. Gennis, John-Demian Sauer
Publikováno v:
EMBO Rep
The success of Staphylococcus aureus as a pathogen is due to its capability of fine‐tuning its cellular physiology to meet the challenges presented by diverse environments, which allows it to colonize multiple niches within a single vertebrate host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bcc4e314ed5f80b76f6e9e05db82c4
https://doi.org/10.15252/embr.201845832
https://doi.org/10.15252/embr.201845832
Autor:
Thomas E. Kehl-Fie, Eliot S. Joya, Christopher A. McDevitt, Jana N. Radin, Paola K. Párraga Solórzano, Stephanie L. Neville, Erin B. Brazel, Jessica L. Kelliher
Publikováno v:
Infect Immun
To control infection, mammals actively withhold essential nutrients, including the transition metal manganese, by a process termed nutritional immunity. A critical component of this host response is the manganese-chelating protein calprotectin. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4716ab1adbc2450aaf49a824a952d1da
https://pubmed.ncbi.nlm.nih.gov/32205403
https://pubmed.ncbi.nlm.nih.gov/32205403
Publikováno v:
mBio, Vol 10, Iss 4, p e01321-19 (2019)
mBio
mBio, Vol 10, Iss 4 (2019)
mBio
mBio, Vol 10, Iss 4 (2019)
Two-component regulatory systems enable bacteria to adapt to changes in their environment during infection by altering gene expression and coordinating antihost responses. Despite the critical role of two-component systems in bacterial survival and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcff2bb2e71ec46f0b7b3358fae93476
https://doaj.org/article/3ce22d0114b740dbac89c9c5b46dc64c
https://doaj.org/article/3ce22d0114b740dbac89c9c5b46dc64c
Autor:
Thomas E. Kehl-Fie, James M. Slauch, Paola K. Párraga Solórzano, Jessica L. Kelliher, Kyle P. Grim, Rouhallah Ramezanifard, Jana N. Radin
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007971 (2019)
PLoS Pathogens
PLoS Pathogens
The ability of Staphylococcus aureus and other pathogens to consume glucose is critical during infection. However, glucose consumption increases the cellular demand for manganese sensitizing S. aureus to host-imposed manganese starvation. The current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf39e1b42e45ac55c27de66b18ed41ea
https://doaj.org/article/7b023c0d80744da4b0ea9daddb491223
https://doaj.org/article/7b023c0d80744da4b0ea9daddb491223