Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Paola Gastaldi"'
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New Synthesis of Substituted 2-Carboxyindole Derivatives: Versatile Introduction of a Carbamoylethynyl Moiety at the C-3 Position
Autor: Cheryl T. Hewkin, Alfredo Cugola, Paola Gastaldi, Romano Di Fabio, Nadia Conti, Fabrizio Micheli, Anna M. Quaglia
Publikováno v: Archiv der Pharmazie. 332:55-58
A novel series of 3-carbamoylethynyl-2-carboxyindoles, antagonists acting at the strychnine-insensitive glycine binding site associated with the NMDA receptor, has been synthesised. This new versatile approach involves the introduction of a 2-chloroe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38135c7ac174c992de0797c33fd59f70
https://doi.org/10.1002/(sici)1521-4184(19993)332:2<55::aid-ardp55>3.0.co
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3
Substituted Indole-2-carboxylates as in Vivo Potent Antagonists Acting as the Strychnine-Insensitive Glycine Binding Site
Autor: Luciana Rossi, A. Feriani, Fabrizio Micheli, Anna M. Quaglia, Anna-Maria Capelli, David G. Trist, Paola Gastaldi, Angelo Reggiani, Alfredo Cugola, E. Ratti, Daniele Donati, Angelo Pecunioso, Manolo Mugnaini, Cheryl T. Hewkin, R. Di Fabio, Nadia Conti, Giovanna Tedesco, Andrea Missio, Giovanni Gaviraghi
Publikováno v: Journal of Medicinal Chemistry. 40:841-850
A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions induced b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27560a1551c483698a602ee0a0e903ed
https://doi.org/10.1021/jm960644a
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4
ChemInform Abstract: New Synthesis of Substituted 2-Carboxyindole Derivatives: Versatile Introduction of a Carbamoylethynyl Moiety at the C-3-Position
Autor: Paola Gastaldi, Anna M. Quaglia, Nadia Conti, Alfredo Cugola, Romano Di Fabio, Fabrizio Micheli, Cheryl T. Hewkin
Publikováno v: ChemInform. 30
A novel series of 3-carbamoylethynyl-2-carboxyindoles, antagonists acting at the strychnine-insensitive glycine binding site associated with the NMDA receptor, has been synthesised. This new versatile approach involves the introduction of a 2-chloroe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::918945d576cd5165255b46449160a9c5
https://doi.org/10.1002/chin.199926117
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6
Synthesis and pharmacological characterisation of a conformationally restrained series of indole-2-carboxylates as in vivo potent glycine antagonists
Autor: Daniele Donati, Paola Gastaldi, Romano Di Fabio, Simone Giacobbe, Alfredo Cugola, Gianluca Araldi, Davide Baraldi, Giorgio Pentassuglia, Fabrizio Micheli
Publikováno v: Farmaco (Societa chimica italiana : 1989). 56(10)
After the identification of GV150526, the indole-2-carboxylate template was further explored in order to identify novel potential anti-stroke agents. In particular, the SAR of the side chain present at the C-3 position of the indole nucleus was widel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2daec2fd265b956fa283791a71bf265
https://pubmed.ncbi.nlm.nih.gov/11718273
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7
Substituted indole-2-carboxylates as potent antagonists of the glycine binding site associated with the NMDA receptor
Autor: Fabrizio Micheli, Davide Baraldi, Carla Marchioro, Paola Gastaldi, Manolo Mugnaini, Luciana Rossi, Angelo Pecunioso, Romano Di Fabio, Nadia Conti, Giorgio Pentassuglia, Alfredo Cugola, Simone Giacobbe
Publikováno v: Archiv der Pharmazie. 332(8)
A novel series of indole-2-carboxylate analogues of GV150526 (1) in which the propenoic double bond was substituted with different "probes" or replaced by a isosteric cyclopropyl moiety were synthesized and evaluated for their affinity profile in ord
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbded892050eab57b28a4720c7b28b60
https://pubmed.ncbi.nlm.nih.gov/10489537
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