Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Paola Gamba"'
Autor:
Erica Staurenghi, Gabriella Testa, Valerio Leoni, Rebecca Cecci, Lucrezia Floro, Serena Giannelli, Eugenio Barone, Marzia Perluigi, Gabriella Leonarduzzi, Barbara Sottero, Paola Gamba
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 435 (2024)
Down syndrome (DS) is a complex chromosomal disorder considered as a genetically determined form of Alzheimer’s disease (AD). Maintenance of brain cholesterol homeostasis is essential for brain functioning and development, and its dysregulation is
Externí odkaz:
https://doaj.org/article/f196c69f618141d8887f99601ff9edc1
Autor:
Sara Madaschi, Eugenia Resmini, Silvia Bonfadini, Giulia Massari, Paola Gamba, Marco Sandri, Stefano Calza, Elena Cimino, Emanuela Zarra, Silvia Dotti, Cristina Mascadri, Barbara Agosti, Emirena Garrafa, Angela Girelli
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-11 (2022)
Abstract Introduction The role of glycemic control, both prior and during hospitalization, on mortality from COVID-19 in diabetic patients is debated. Furthermore, it is not clear whether hyperglycemia has a direct effect or requires inflammatory mec
Externí odkaz:
https://doaj.org/article/3136bf0638974d0184ac8017c25eacb4
Autor:
Gabriella Testa, Serena Giannelli, Barbara Sottero, Erica Staurenghi, Giorgio Giaccone, Paola Caroppo, Paola Gamba, Gabriella Leonarduzzi
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 631 (2023)
Considerable evidence indicates that cholesterol oxidation products, named oxysterols, play a key role in several events involved in Alzheimer’s disease (AD) pathogenesis. Although the majority of oxysterols causes neuron dysfunction and degenerati
Externí odkaz:
https://doaj.org/article/41ceca56dce946fd9bfd664e232ec26a
Autor:
Erica Staurenghi, Valerio Leoni, Marco Lo Iacono, Barbara Sottero, Gabriella Testa, Serena Giannelli, Gabriella Leonarduzzi, Paola Gamba
Publikováno v:
Antioxidants, Vol 11, Iss 11, p 2168 (2022)
The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis. Being astrocytes the main producers o
Externí odkaz:
https://doaj.org/article/b095b2435a404d40ac4eda8ffadbc6ae
Autor:
Erica Staurenghi, Valentina Cerrato, Paola Gamba, Gabriella Testa, Serena Giannelli, Valerio Leoni, Claudio Caccia, Annalisa Buffo, Wendy Noble, Beatriz Gomez Perez-Nievas, Gabriella Leonarduzzi
Publikováno v:
Redox Biology, Vol 39, Iss , Pp 101837- (2021)
Among Alzheimer's disease (AD) brain hallmarks, the presence of reactive astrocytes was demonstrated to correlate with neuronal loss and cognitive deficits. Evidence indeed supports the role of reactive astrocytes as mediators of changes in neurons,
Externí odkaz:
https://doaj.org/article/f2828f617de545a1ae710d9a775e594c
Autor:
Andrea Civra, Rachele Francese, Paola Gamba, Gabriella Testa, Valeria Cagno, Giuseppe Poli, David Lembo
Publikováno v:
Redox Biology, Vol 19, Iss , Pp 318-330 (2018)
A novel innate immune strategy, involving specific cholesterol oxidation products as effectors, has begun to reveal connections between cholesterol metabolism and immune response against viral infections. Indeed, 25-hydroxycholesterol (25HC) and 27-h
Externí odkaz:
https://doaj.org/article/0723f9d27e674116bee02bf6e75a5651
Autor:
Beyza Vurusaner, Simona Gargiulo, Gabriella Testa, Paola Gamba, Gabriella Leonarduzzi, Giuseppe Poli, Huveyda Basaga
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 400-410 (2018)
Autophagy has been shown to be stimulated in advanced atherosclerotic plaques by metabolic stress, inflammation and oxidized lipids. The lack of published studies addressing the potential stimulation of pro-survival autophagy by oxysterols, a family
Externí odkaz:
https://doaj.org/article/801e3f38a8794521bfc48ffe692d088d
Autor:
Gabriella Testa, Erica Staurenghi, Serena Giannelli, Simona Gargiulo, Michela Guglielmotto, Massimo Tabaton, Elena Tamagno, Paola Gamba, Gabriella Leonarduzzi
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 423-431 (2018)
It is now established that cholesterol oxidation products (oxysterols) are involved in several events underlying Alzheimer's disease (AD) pathogenesis. Of note, certain oxysterols cause neuron dysfunction and degeneration but, recently, some of them
Externí odkaz:
https://doaj.org/article/22c9b1cba0444471aaea76f33f06d0b8
Autor:
Erica Staurenghi, Serena Giannelli, Gabriella Testa, Barbara Sottero, Gabriella Leonarduzzi, Paola Gamba
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 1890 (2021)
In recent decades, the impairment of cholesterol metabolism in the pathogenesis of Alzheimer’s disease (AD) has been intensively investigated, and it has been recognized to affect amyloid β (Aβ) production and clearance, tau phosphorylation, neur
Externí odkaz:
https://doaj.org/article/68f0c1d2a38f42c8b6136a92f5d0922d
Autor:
Gabriella Testa, Erica Staurenghi, Chiara Zerbinati, Simona Gargiulo, Luigi Iuliano, Giorgio Giaccone, Fausto Fantò, Giuseppe Poli, Gabriella Leonarduzzi, Paola Gamba
Publikováno v:
Redox Biology, Vol 10, Iss C, Pp 24-33 (2016)
Alzheimer's disease (AD) is a gradually debilitating disease that leads to dementia. The molecular mechanisms underlying AD are still not clear, and at present no reliable biomarkers are available for the early diagnosis. In the last several years, t
Externí odkaz:
https://doaj.org/article/062e1ca7b69649ba9efec1670064ba74