Výsledky vyhledávání - "Paola Costa-Mallen"

Brain iron concentrations in regions of interest and relation with serum iron levels in Parkinson disease

Autor: Kevin C. Cain, Christopher Gatenby, Paola Costa-Mallen, Kenneth R. Maravilla, Yoshimi Anzai, Sally Friend, Shu-Ching Hu, Pinky Agarwal

Publikováno v: Journal of the Neurological Sciences. 378:38-44

Brain iron has been previously found elevated in the substantia nigra pars compacta (SNpc), but not in other brain regions, of Parkinson’s disease (PD) patients. However, iron in circulation has been recently observed to be lower than normal in PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9917c5520cec42467fb789af42c26b25
https://doi.org/10.1016/j.jns.2017.04.035

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Smoking and haptoglobin phenotype modulate serum ferritin and haptoglobin levels in Parkinson disease

Autor: Paola Costa-Mallen, Shu Ching Hu, Pinky Agarwal, Cyrus P. Zabetian, Harvey Checkoway, Dora Yearout

Publikováno v: Journal of Neural Transmission. 123:1319-1330

The phenotype Hp 2-1 of haptoglobin has been previously associated with increased risk of Parkinson disease (PD) and with serum iron abnormalities in PD patients. Tobacco smoking has been consistently observed in epidemiology studies to be inversely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da7eed99595c7da18f07a0b5412100e
https://doi.org/10.1007/s00702-016-1590-x

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The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease

Autor: Gary M. Franklin, Terri Smith-Weller, Aram Zabeti, Phillip D. Swanson, W. T. Longstreth, Harvey Checkoway, Michael J. Edenfield, Paola Costa-Mallen, Sayed M.H. Sadrzadeh

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :216-222

Oxidative stress and iron have been widely implicated in the etiology of Parkinson's disease (PD). Hemoglobin is the richest source of iron in the body. The human Haptoglobin (Hp) protein is a plasma alpha-2 glycoprotein that removes free Hemoglobin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d83bbdd5ff19ff3016f300c52860431
https://doi.org/10.1002/ajmg.b.30593

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Haptoglobin phenotype modifies serum iron levels and the effect of smoking on Parkinson disease risk

Autor: Cyrus P. Zabetian, Pinky Agarwal, John W. Roberts, Shu Ching Hu, Harvey Checkoway, Dora Yearout, James B. Leverenz, Paola Costa-Mallen, Ali Samii

Publikováno v: Parkinsonismrelated disorders. 21(9)

Haptoglobin is a hemoglobin-binding protein that exists in three functionally different phenotypes, and haptoglobin phenotype 2-1 has previously been associated with Parkinson disease (PD) risk, with mechanisms not elucidated. Some evidence is emergi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9de245d46127b0eaf5bb39df7cb275
https://pubmed.ncbi.nlm.nih.gov/26708126

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5′ and 3′ region variability in the dopamine transporter gene ( SLC6A3 ), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study

Autor: Sharon L.R. Kardia, Jordan A. Firestone, Zahra Afsharinejad, Harvey Checkoway, David L. Eaton, Christopher S. Carlson, Phillip D. Swanson, Paola Costa-Mallen, Samir N. P. Kelada, Terri Smith Weller, Gary M. Franklin, Lucio G. Costa, W. T. Longstreth, Karen M. Powers

Publikováno v: Human Molecular Genetics. 15:3055-3062

The dopamine transporter gene (SLC6A3) is a candidate gene for Parkinson's disease (PD) on the basis of its critical role in dopaminergic neurotransmission. Previously, we identified 22 SNPs in the 5' region of SLC6A3, which segregate as eight haplot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cb46876bb05e781b285abadbaec0b6
https://doi.org/10.1093/hmg/ddl247

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Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men

Autor: Lucio G. Costa, Harvey Checkoway, Paola Costa-Mallen

Publikováno v: Neuroscience Letters. 385:158-162

Tobacco smoke inhibits monoamine oxidase-B (MAO-B) activity in vitro and in vivo, suggesting that MAO-B inhibition is a possible contributing factor to tobacco smoke addiction. Thus, MAO-B is a possible candidate gene for predisposition to smoking. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad07bfe638f8c4fcc95cd487ba0273c
https://doi.org/10.1016/j.neulet.2005.05.035

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Paraoxonase 2 (PON2) polymorphisms and Parkinson's disease

Autor: Samir N. P. Kelada, Lucio G. Costa, Harvey Checkoway, Clement E. Furlong, Paola Costa-Mallen, Terri Smith Weller, Gary M. Franklin, William T. Longstreth, Fred M. Farin, Hannah Malia A Viernes, Philip D. Swanson

Publikováno v: Neuroscience Research Communications. 34:130-135

Oxidative stress may contribute to the pathogenesis of Parkinson's disease (PD). Paraoxonase 2 (PON2) is an ubiquitously expressed protein which displays antioxidant properties, though it does not have paraoxonase or arylesterase activity like other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eceebb1e2cfd04fa343c154cf6fa264c
https://doi.org/10.1002/nrc.20008

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DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls

Autor: Phillip D. Swanson, Paola Costa-Mallen, Harvey Checkoway, Gary M. Franklin, Zahra Afsharinejad, Terri Smith-Weller, Federico M. Farin, W. T. Longstreth, Hannah Malia A Viernes, Samir N. P. Kelada, Lucio G. Costa

Publikováno v: Movement Disorders. 19:76-83

The allele G of the intron 13 G/A polymorphism of the monoamine oxidase B gene (MAO-B) has been associated with Parkinson's disease (PD) in several studies. Apart from a potential direct effect on splicing processes, the association of this intronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dec335c489805059c9c31e516492518
https://doi.org/10.1002/mds.10624

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The Eco RV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease

Autor: Alex Cohen, Mark Fishel, Paola Costa-Mallen, Lucio G. Costa, Harvey Checkoway, Phillip D. Swanson, Gary M. Franklin, Terri Smith-Weller

Publikováno v: Neuroscience Letters. 278:33-36

We previously observed an association with Parkinson's (PD), and modification of the effect of smoking on PD, by a polymorphism of the monoamine oxidase B (MAO-B) gene. The A form of monoamine oxidase (MAO-A) shares with MAO-B many characteristics th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d086fe076d700586910dfd35b389def3
https://doi.org/10.1016/s0304-3940(99)00890-3

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