Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Paola Contini"'
Autor:
Alice Balboni, Giorgia Ailuno, Sara Baldassari, Giuliana Drava, Andrea Petretto, Nicole Grinovero, Ornella Cavalleri, Elena Angeli, Andrea Lagomarsino, Paolo Canepa, Alessandro Corsaro, Beatrice Tremonti, Federica Barbieri, Stefano Thellung, Paola Contini, Katia Cortese, Tullio Florio, Gabriele Caviglioli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Glioblastoma (GBM), one of the deadliest brain tumors, accounts for approximately 50% of all primary malignant CNS tumors, therefore novel, highly effective remedies are urgently needed. Boron neutron capture therapy, which has recently repo
Externí odkaz:
https://doaj.org/article/2affd4e6c5004727a6a85e10b1e73128
Autor:
Emanuele Gotelli, Stefano Soldano, Carol Feghali-Bostwick, Paola Montagna, Rosanna Campitiello, Paola Contini, Marco Mora, Roberto Benelli, Elvis Hysa, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSystemic sclerosis (SSc) is a complex autoimmune connective tissue disease characterized by microvascular damage, immune system reactivity and progressive fibrosis of skin and internal organs. Interstitial lung disease is the leading caus
Externí odkaz:
https://doaj.org/article/73b2a5ac44a74f418cb974b1d666da14
Autor:
Keith E Kennedy, Nicole Kerlero de Rosbo, Antonio Uccelli, Maria Cellerino, Federico Ivaldi, Paola Contini, Raffaele De Palma, Hanne F Harbo, Tone Berge, Steffan D Bos, Einar A Høgestøl, Synne Brune-Ingebretsen, Sigrid A de Rodez Benavent, Friedemann Paul, Alexander U Brandt, Priscilla Bäcker-Koduah, Janina Behrens, Joseph Kuchling, Susanna Asseyer, Michael Scheel, Claudia Chien, Hanna Zimmermann, Seyedamirhosein Motamedi, Josef Kauer-Bonin, Julio Saez-Rodriguez, Melanie Rinas, Leonidas G Alexopoulos, Magi Andorra, Sara Llufriu, Albert Saiz, Yolanda Blanco, Eloy Martinez-Heras, Elisabeth Solana, Irene Pulido-Valdeolivas, Elena H Martinez-Lapiscina, Jordi Garcia-Ojalvo, Pablo Villoslada
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1010980 (2024)
Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. W
Externí odkaz:
https://doaj.org/article/c5917d61aa834152b3fb2018484da2fd
Autor:
Arnaud N’Guessan, Senthilkumar Kailasam, Fatima Mostefai, Raphaël Poujol, Jean-Christophe Grenier, Nailya Ismailova, Paola Contini, Raffaele De Palma, Carsten Haber, Volker Stadler, Guillaume Bourque, Julie G. Hussin, B. Jesse Shapiro, Jörg H. Fritz, Ciriaco A. Piccirillo
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107394- (2023)
Summary: Here, we exploit a deep serological profiling strategy coupled with an integrated, computational framework for the analysis of SARS-CoV-2 humoral immune responses. Applying a high-density peptide array (HDPA) spanning the entire proteomes of
Externí odkaz:
https://doaj.org/article/195d959ff65b4182afe4eeeca40ed734
Autor:
Mehdi Benamar, Qian Chen, Janet Chou, Amélie M. Julé, Rafik Boudra, Paola Contini, Elena Crestani, Peggy S. Lai, Muyun Wang, Jason Fong, Shira Rockwitz, Pui Lee, Tsz Man Fion Chan, Ekin Zeynep Altun, Eda Kepenekli, Elif Karakoc-Aydiner, Ahmet Ozen, Perran Boran, Fatih Aygun, Pinar Onal, Ayse Ayzit Kilinc Sakalli, Haluk Cokugras, Metin Yusuf Gelmez, Fatma Betul Oktelik, Esin Aktas Cetin, Yuelin Zhong, Maria Lucia Taylor, Katherine Irby, Natasha B. Halasa, Elizabeth H. Mack, Overcoming COVID-19 Investigators, Sara Signa, Ignazia Prigione, Marco Gattorno, Nicola Cotugno, Donato Amodio, Raif S. Geha, Mary Beth Son, Jane Newburger, Pankaj B. Agrawal, Stefano Volpi, Paolo Palma, Ayca Kiykim, Adrienne G. Randolph, Gunnur Deniz, Safa Baris, Raffaele De Palma, Klaus Schmitz-Abe, Louis-Marie Charbonnier, Lauren A. Henderson, Talal A. Chatila
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcomes were previously correlated with Notch4 exp
Externí odkaz:
https://doaj.org/article/a39c807bcee64be782682857c935eead
Autor:
Anna Laura Cremonini, Andrea Pasta, Federico Carbone, Luca Visconti, Matteo Casula, Edoardo Elia, Aldo Bonaventura, Luca Liberale, Maria Bertolotto, Nathan Artom, Silvia Minetti, Paola Contini, Daniela Verzola, Roberto Pontremoli, Francesca Viazzi, Giorgio Luciano Viviani, Stefano Bertolini, Aldo Pende, Fabrizio Montecucco, Livia Pisciotta
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Background and Aim: High lipoprotein(a) [Lp(a)] is a well-established cardiovascular (CV) risk factor, but the effect of mildly elevated Lp(a) on CV health is largely unknown. Our aim was to evaluate if Lp(a) is associated with the severity of caroti
Externí odkaz:
https://doaj.org/article/1b5685523d594be69391fc489b7d0d84
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Allergy is an inflammatory process determined by a cascade of immune events characterized by T-helper 2 lymphocytes polarization leading to interleukin-4 upregulation, IgE secretion, and mast cell and eosinophil activation. HLA-G molecules, both in m
Externí odkaz:
https://doaj.org/article/bf9999646233443c87e8dd50deedd937
Autor:
Debora Soncini, Claudia Martinuzzi, Pamela Becherini, Elisa Gelli, Samantha Ruberti, Katia Todoerti, Luca Mastracci, Paola Contini, Antonia Cagnetta, Antonella Laudisi, Fabio Guolo, Paola Minetto, Maurizio Miglino, Sara Aquino, Riccardo Varaldo, Daniele Reverberi, Matteo Formica, Mario Passalacqua, Alessio Nencioni, Antonino Neri, Mehmet K. Samur, Nikhil C. Munshi, Mariateresa Fulciniti, Roberto M. Lemoli, Michele Cea
Publikováno v:
Haematologica, Vol 107, Iss 6 (2021)
Identification of novel vulnerabilities in the context of therapeutic resistance is emerging as a key challenge for cancer treatment. Recent studies have detected pervasive aberrant splicing in cancer cells, supporting its targeting for novel therape
Externí odkaz:
https://doaj.org/article/309434a4c8104d54bfdbb57fcf74b015
Autor:
Amelia Chiara Trombetta, Stefano Soldano, Paola Contini, Veronica Tomatis, Barbara Ruaro, Sabrina Paolino, Renata Brizzolara, Paola Montagna, Alberto Sulli, Carmen Pizzorni, Vanessa Smith, Maurizio Cutolo
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Systemic sclerosis (SSc) is a disorder characterized by immune system alterations, vasculopathy and fibrosis. SSc-related interstitial lung disease (ILD) represents a common and early complication, being the leading cause of morta
Externí odkaz:
https://doaj.org/article/02c3b7dae23a4fe183230634b25edca3
Autor:
Maurizio Cutolo, Stefano Soldano, Paola Montagna, Amelia Chiara Trombetta, Paola Contini, Barbara Ruaro, Alberto Sulli, Stefano Scabini, Emanuela Stratta, Sabrina Paolino, Carmen Pizzorni, Vanessa Smith, Renata Brizzolara
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-9 (2018)
Abstract Background Systemic sclerosis (SSc) is characterized by vasculopathy and progressive fibrosis. CTLA4-Ig (abatacept) is able to interact with the cell surface costimulatory molecule CD86 and downregulate the target cell. The aim of this study
Externí odkaz:
https://doaj.org/article/8fb2d27c8780487180edfa49ae8eb1c2