Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Paola Comi"'
Autor:
Giovanni Palma, Paola Comi, Raffaella Chiaramonte, Katia Rea, Leonardo Mirandola, Sara Larocca
Publikováno v:
Archive of Oncology, Vol 17, Iss 3-4, Pp 72-77 (2009)
Notch history begins in 1919 with Thomas Hunt Morgan studies on fruit fly mutants. From then, this gene aroused lively interest in the scientific community since it is involved in a wide variety of processes, including morphogenesis, tissue homeostas
Autor:
C. Fazi, Paola Comi, Raffaella Chiaramonte, Valentina Cecchinato, E. Erba, Bruno Brando, Andrea Basile, Barbara Scarpati
Publikováno v:
Leukemia Research. 32:791-797
T acute lymphoblastic leukemia cell lines treated with hexamethylene bisacetamide (HMBA) undergo a delay in cell cycle progression and increase susceptibility to apoptosis, although they never overcome the differentiation block. In accordance with ch
Autor:
Raffaella Chiaramonte, Brunella Cristofaro, Paola Comi, Monica Nizzardo, Gajanan V. Sherbet, Valentina Cecchinato, Andrea Basile
Publikováno v:
Biochemical Pharmacology. 74:1568-1574
Resveratrol (RES) is a natural occurring phytoalexin that has been shown to have chemopreventive activity. Resveratrol acts both by suppressing cell proliferation and inducing apoptosis in a variety of cancer cell lines. In this study, we show that R
Publikováno v:
Journal of Cellular Biochemistry. 103:212-220
The effects of hyperthermia on the expression of p53, the apoptosis-associated genes Bax and Bcl-2, Notch and S100A4 have been studied in the HepG2 cell line and the HUT cell line derived from HepG2, adapted for growth in hyperthermic conditions. Hyp
Autor:
Elena Tassi, Valentina Cecchinato, Paola Comi, Raffaella Chiaramonte, Andrea Biondi, Vincenzo Rossi, Andrea Basile, Elisabetta Calzavara
Publikováno v:
Cancer Letters. 219:113-120
NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblast
Autor:
Anna Serra, Daniela Capello, Raffaella Chiaramonte, Gianluca Gaidano, Marta Sabbadini, Gajanan V. Sherbet, Elisabetta Calzavara, Paola Comi, Francesca Balordi
Publikováno v:
Università degli Studi del Piemonte Orientale-IRIS
The transduction of Notch signal plays an intricate role in cell differentiation and pathogenesis of haematological malignancies as well as in certain congenital conditions. We found no genomic changes in either gene in 34 leukaemic samples and 25 le
Publikováno v:
DNA Sequence. 9:163-169
We defined a sub-family of zinc finger proteins by computer analyses and comparisons of five new finger domains against protein databases. This subclass of the cysteine-cysteine/histidine-histidine motif shows additional well conserved amino acid pat
Autor:
Jeanette A.M. Maier, Paola Comi, Massimo Mariotti, Maria Prat, Paolo M. Comoglio, Marco R. Soria, Adriana Albini
Publikováno v:
International Journal of Cancer. 65:168-172
Kaposi’s sarcoma is a highly vascularired multifocal tumor which frequently appears as a complication of HIV infection. It has been suggested that a disorder in the cy-tokine network may contribute to the development of the disease. We examined the
Autor:
Paola Comi, Franco Pagani, Silvia Bradamante, Giovanni Ragnotti, Livia Barenghi, Jeanette A.M. Maier
Publikováno v:
European Journal of Biochemistry. 221:35-41
The adherence of monocytes to the endothelium is an early event in atherogenesis. We have investigated this process by examining whether native and oxidized low-density and high-density lipoproteins could modulate this process. Only oxidized low-dens
Publikováno v:
Molecular and Cellular Biochemistry. 232:159-161
Two cytosine-adenine (CA) repeats CAR/CAL and RepIN20 occur in the human SEL1L gene, which is regarded as a candidate gene for insulin-dependent diabetes mellitus (IDDM) and Grave's disease. We have characterized these repeats to determine if they mi