Výsledky vyhledávání - "Paola Ciapetti"

Akademický článek

The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.

Autor: Céline Ronin, David Mendes Costa, Joana Tavares, Joana Faria, Fabrice Ciesielski, Paola Ciapetti, Terry K Smith, Jane MacDougall, Anabela Cordeiro-da-Silva, Iain K Pemberton

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0193602 (2018)

The de novo crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSir2rp1) has been solved at 1.99Å in complex with an acetyl-lysine peptide substrate. The structure is broadly commensurate with Hst2/SIRT2

Externí odkaz: https://doaj.org/article/e4b7312a30c44b1bbe495d18d3b04ba1

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.

Autor: Luís Gaspar, Ross P Coron, Paul KongThoo Lin, David M Costa, Begoña Perez-Cabezas, Joana Tavares, Meritxell Roura-Ferrer, Isbaal Ramos, Céline Ronin, Louise L Major, Fabrice Ciesielski, Iain K Pemberton, Jane MacDougall, Paola Ciapetti, Terry K Smith, Anabela Cordeiro-da-Silva

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006180 (2018)

Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-rel

Externí odkaz: https://doaj.org/article/f6e4a1edfb98480288b07d74ed1a4300

Zobrazit plný text záznamu

Plný text ve formátu HTML

Towards chemical validation of Leishmania infantum ribose 5-phosphate isomerase as a drug target

Autor: Anabela Cordeiro-da-Silva, Louise L. Major, Mónica Sá, Paola Ciapetti, Jane MacDougall, Terry K. Smith, Fabrice Ciesielski, Joana Tavares, Nuno Santarém, Nathalie Trouche, Emily A. Dickie, Iain K. Pemberton, Céline Ronin

Publikováno v: Antimicrob Agents Chemother

Funding from the European Community's Seventh Framework Programme under grant agreements No. 602773 (Project KINDRED) was received for all partners in this work. This work also received funds from FCT - Fundação para a Ciência e a Tecnologia/Minis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03593d13f339e842adf9b91dc2d37197
https://hdl.handle.net/10023/24164

Zobrazit plný text záznamu

ChemInform Abstract: Iron- and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard Reagents

Autor: Remy Campagne, Laurine Gonnard, Baptiste Barré, Amandine Guérinot, Paola Ciapetti, Janine Cossy, Sébastien Reymond, Julien Marin, Marie Brellier

Publikováno v: ChemInform. 46

Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f27e15804560c3054ed4253ab7060ab0
https://doi.org/10.1002/chin.201519070

Zobrazit plný text záznamu

List of Contributors

Autor: Anne Badel, Patrick Bazzini, Frans M. Belpaire, Alexandre Borrel, Koen Boussery, Christopher Brice, Anne-Claude Camproux, David Cavalla, Paola Ciapetti, Hongming Chen, Yong Mi Choi-Sledeski, Bernd Clement, Gordon M. Cragg, Patrick M. Dansette, Pierre deMontigny, Ji-Cui Dong, Iain G. Dougall, Ola Engkvist, Bernard Faller, Bennett T. Farmer, Delphine Flatters, Bruno Galli, Colette Geneix, Bruno Giethlen, Serge Grisoni, Gerhard Gross, David Harris, Yuichi Hashimoto, Chris Ho, Andrew L. Hopkins, Hiba Abi Hussein, Peter Imming, Minoru Ishikawa, Tim Jonckers, Sabine Kopp, David G.I. Kingston, Thierry Kogej, Sophie Lasseur, Dominique Lesuisse, Harvey Lieberman, Richard Luthi, Anne-Christine Macherey, André Mann, Raffaella G. Balocco Mattavelli, Christophe Morice, Richard Morphy, David J. Newman, Anne Olivier, Michel Petitjean, Pierre Raboisson, Zoran Rankovic, Leslie Regad, Allen B. Reitz, Bernd U. Riebesehl, Jean-Philippe Rocher, Tiago Rodrigues, A. Romeo, Jean-Michel Rondeau, Laurent Schaeffer, Jean-Michel Scherrmann, Gisbert Schneider, Herman Schreuder, Wolfgang Sippl, Erin M. Skoda, Olivier Taboureau, Bernard Testa, John Unitt, Johan Van de Voorde, Walter M.M. Van den Broeck, N. Murti Vemuri, Venkata Velvadapu, Franz Weiberth, Bruno Villoutreix, Camille G. Wermuth, Peter Wipf, Gerhard Wolber

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ac78ac235601f775503cbb8ecc81d18
https://doi.org/10.1016/b978-0-12-417205-0.00044-4

Zobrazit plný text záznamu

Iron- and cobalt-catalyzed arylation of azetidines, pyrrolidines, and piperidines with Grignard reagents

Autor: Remy Campagne, Baptiste Barré, Janine Cossy, Sébastien Reymond, Amandine Guérinot, Laurine Gonnard, Paola Ciapetti, Julien Marin, Marie Brellier

Publikováno v: Organic letters. 16(23)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5beaa481df8fa5bcbd31f18c2bb1d810
https://pubmed.ncbi.nlm.nih.gov/25401684

Zobrazit plný text záznamu

2-Amino-4-bromobutanoic Acid

Autor: Massimo Falorni, Maurizio Taddei, André Mann, Paola Ciapetti

Publikováno v: Molecules Online. 2:86-93

(2S)- and (2R)-2-Amino-4-bromobutanoic acid were prepared starting from N-Boc-glutamic acid α tert-butyl ester. The double tert-butyl protection was necessary to prevent a partial racemisation during Barton’s radical decarboxylation used to transf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a908a1c996b6f3c93d29abea374ba6c9
https://doi.org/10.1007/s007830050060

Zobrazit plný text záznamu

ChemInform Abstract: CrCl2 Mediated Addition of Allylic Halides or Phosphates to N- Protected α-Amino Aldehydes. Stereocontrolled Synthesis of a New Core for C2 Symmetric HIV-Protease Inhibitors

Autor: Massimo Falorni, Maurizio Taddei, Paola Ciapetti

Publikováno v: ChemInform. 27

The addition of γ-monosubstituted allylchromium(III) reagents to N-protected α-amino aldehydes proceeds in a stereoconvergent manner in contrast with the case of the unsubstituted reagents, where the stereoselectivity depends on the nature of the g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c72a1d95e74c5385160c894b4958533
https://doi.org/10.1002/chin.199638054

Zobrazit plný text záznamu

ChemInform Abstract: Synthesis of N-Fmoc-α-amino Acids Carrying the Four DNA Nucleobases in the Side Chain

Autor: Paola Ciapetti, Maurizio Taddei, Francesco Soccolini

Publikováno v: ChemInform. 28

Four new N-Fmoc α-amino acids carrying a nucleobase in the side chain were prepared starting from l-glutamic acid. N-Boc-glutamic acid α benzyl ester underwent a radical decarboxylation in the presence of CBrCl3 to give the corresponding 2-amino-4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41962e3c1948c525698dd88c82b8f62f
https://doi.org/10.1002/chin.199716227

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání