Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL

Autor: Luca Tottone, Nadezda Zhdanovskaya, Álvaro Carmona Pestaña, Michele Zampieri, Fabrizio Simeoni, Sara Lazzari, Valeria Ruocco, Maria Pelullo, Paola Caiafa, Maria Pia Felli, Saula Checquolo, Diana Bellavia, Claudio Talora, Isabella Screpanti, Rocco Palermo

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch signaling. Aberrant Notch signaling in T-ALL occurs by NOTCH1 gain-of-function mutations and by

Externí odkaz: https://doaj.org/article/386e18528e32479ebe765fc446f80a8a

Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles.

Autor: Fabio Ciccarone, Francesca Gioia Klinger, Angela Catizone, Roberta Calabrese, Michele Zampieri, Maria Giulia Bacalini, Massimo De Felici, Paola Caiafa

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46927 (2012)

Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1. Here, we show that ADP-ribo

Externí odkaz: https://doaj.org/article/14f6ea8bd7d8420e962de08e32a40a35

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

Autor: Michele Zampieri, Beatrix Grubeck-Loebenstein, Alexander Bürkle, Mikko Hurme, P. Eline Slagboom, Florence Debacq-Chainiaux, Olivier Toussaint, Maria A. Blasco, Tilman Grune, Claudio Franceschi, Ewa Sikora, Maria Giulia Bacalini, Antti Hervonen, Eugène H.J.M. Jansen, Stefano Tagliatesta, Valentina Aversano, Anna Reale, Martijn E.T. Dollé, Miriam Capri, Marco Malavolta, Maria Moreno-Villanueva, Efstathios S. Gonos, Christiane Schön, Nicolle Breusing, Fabio Ciccarone, Jürgen Bernhardt, Paola Caiafa

Publikováno v: Geroscience, 43(3), 1283-1302. SPRINGER
GeroScience
Bacalini, M G, Reale, A, Malavolta, M, Ciccarone, F, Moreno-Villanueva, M, Dollé, M E T, Jansen, E, Grune, T, Gonos, E S, Schön, C, Bernhardt, J, Grubeck-Loebenstein, B, Sikora, E, Toussaint, O, Debacq-Chainiaux, F, Capri, M, Hervonen, A, Hurme, M, Slagboom, P E, Breusing, N, Aversano, V, Tagliatesta, S, Franceschi, C, Blasco, M A, Bürkle, A, Caiafa, P & Zampieri, M 2021, ' Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study ', GeroScience, vol. 43, no. 3, pp. 1283-1302 . https://doi.org/10.1007/s11357-021-00347-9

Ageing leaves characteristic traces in the DNA methylation make-up of the genome. However, the importance of DNA methylation in ageing remains unclear. The study of subtelomeric regions could give promising insights into this issue. Previously report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a7e6d18327fc45d8ab380f1b4695cf
http://hdl.handle.net/10029/624923

Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project

Autor: Florence Debacq-Chainiaux, Andrea Basso, Tilman Grune, Paola Caiafa, Marco Malavolta, Ewa Sikora, Michele Zampieri, Nicolle Breusing, Efstathios S. Gonos, Martijn E.T. Dollé, Beatrix Grubeck-Loebenstein, Wolfgang Stuetz, Maria Moreno-Villanueva, Alexander Bürkle, Daniela Weber, Eugenio Mocchegiani, Fabio Ciccarone, Eugène H.J.M. Jansen, Antti Hervonen, Claudio Franceschi, Olivier Toussaint, Laura Costarelli, Eline Slagboom, Christiane Schön, Francesco Piacenza, Robertina Giacconi

Publikováno v: Giacconi, R, Costarelli, L, Piacenza, F, Basso, A, Bürkle, A, Moreno-Villanueva, M, Grune, T, Weber, D, Stuetz, W, Gonos, E S, Schön, C, Grubeck-Loebenstein, B, Sikora, E, Toussaint, O, Debacq-Chainiaux, F, Franceschi, C, Hervonen, A, Slagboom, E, Ciccarone, F, Zampieri, M, Caiafa, P, Jansen, E, Dollé, M E T, Breusing, N, Mocchegiani, E & Malavolta, M 2018, ' Zinc-Induced Metallothionein in Centenarian Offspring from a Large European Population : The MARK-AGE Project ', Journals of Gerontology-Series A Biological Sciences and Medical Sciences, vol. 73, no. 6, pp. 745-753 . https://doi.org/10.1093/gerona/glx192
Journal of Gerontology: Medical Sciences, 73(6), 745-753

Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favorably influence longevity, although their role in human aging is not co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3952fb8eae0a8a43e4aea5bb2904b573
https://hdl.handle.net/1887/95475

Defective DNA Methylation/Demethylation Processes Define Aging-Dependent Methylation Patterns

Autor: Fabio Ciccarone, Paola Caiafa, Michele Zampieri

The process of aging culminates in a multitude of chronological irreversible changes at the cellular and molecular levels that push the organism toward a progressive loss of physiological integrity and increased susceptibility to disease. Mounting ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cddba5347c534875eb0868ce5d2043
http://hdl.handle.net/2108/291612