Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Paola Bukuroshi"'
Autor:
Sophie R. Pan, Paul Grootendorst, K. Sandy Pang, Xiaoyu Yan, Inés de Lannoy, Paola Bukuroshi, H Benson Peng, Matthew R. Durk
Publikováno v:
Biopharmaceuticsdrug dispositionREFERENCES. 42(8)
Age, hypercholesterolemia, and vitamin D deficiency are risk factors that increase the brain accumulation of pathogenic β-amyloid peptides (40 and 42), precursors leading to Alzheimer's disease (AD) in humans. The relative changes accompanying aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8566d7ba42012d5f4bc97506bad4a3b9
https://pubmed.ncbi.nlm.nih.gov/34219248
https://pubmed.ncbi.nlm.nih.gov/34219248
Autor:
Edwin C. Y. Chow, Hiroshi Saitoh, Albert P. Li, Paola Bukuroshi, K. Sandy Pang, Lilia Magomedova, Carolyn L. Cummins
Publikováno v:
Biochemical Pharmacology. 155:547-561
In vitro cell-based assays are common screening tools used for the identification of new VDR ligands. For 25-hydroxyvitamin D3 [25(OH)D3] and 1α-hydroxyvitamin D3 [1α(OH)D3], protein expressions of CYP2R1 and CYP27B1, respectively, that form the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29c7e8b2138ff927eeaf570b498e485
https://doi.org/10.1016/j.bcp.2018.07.015
https://doi.org/10.1016/j.bcp.2018.07.015
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:196-204
Vitamin D3 and the synthetic vitamin D analogs, 1α-hydroxyvitamin D3 [1α(OH)D3 ], 1α-hydroxyvitamin D2 [1α(OH)D2 ] and 25-hydroxyvitamin D3 [25(OH)D3 ] were appraised for their vitamin D receptor (VDR) associated-potencies as cholesterol lowering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d6d85ed3e44e1e5ce00a899d4e03e0
https://doi.org/10.1002/bdd.2126
https://doi.org/10.1002/bdd.2126
Publikováno v:
Drug Metabolism and Disposition. 46:75-87
We expanded our published physiologically based pharmacokinetic model (PBPK) on 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], ligand of the vitamin D receptor (VDR), to appraise VDR-mediated pharmacodynamics in mice. Since 1,25(OH)2D3 kinetics was best d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84b34dec6404ecd7e3918f9f9ded37d5
https://doi.org/10.1124/dmd.117.077271
https://doi.org/10.1124/dmd.117.077271
