Výsledky vyhledávání - "Paola Bukuroshi"

Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β-amyloid peptide accumulation in mice

Autor: Sophie R. Pan, Paul Grootendorst, K. Sandy Pang, Xiaoyu Yan, Inés de Lannoy, Paola Bukuroshi, H Benson Peng, Matthew R. Durk

Publikováno v: Biopharmaceuticsdrug dispositionREFERENCES. 42(8)

Age, hypercholesterolemia, and vitamin D deficiency are risk factors that increase the brain accumulation of pathogenic β-amyloid peptides (40 and 42), precursors leading to Alzheimer's disease (AD) in humans. The relative changes accompanying aging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8566d7ba42012d5f4bc97506bad4a3b9
https://pubmed.ncbi.nlm.nih.gov/34219248

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Strategies and limitations associated with in vitro characterization of vitamin D receptor activators

Autor: Edwin C. Y. Chow, Hiroshi Saitoh, Albert P. Li, Paola Bukuroshi, K. Sandy Pang, Lilia Magomedova, Carolyn L. Cummins

Publikováno v: Biochemical Pharmacology. 155:547-561

In vitro cell-based assays are common screening tools used for the identification of new VDR ligands. For 25-hydroxyvitamin D3 [25(OH)D3] and 1α-hydroxyvitamin D3 [1α(OH)D3], protein expressions of CYP2R1 and CYP27B1, respectively, that form the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29c7e8b2138ff927eeaf570b498e485
https://doi.org/10.1016/j.bcp.2018.07.015

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Potencies of vitamin D analogs, 1α-hydroxyvitamin D3, 1α-hydroxyvitamin D2and 25-hydroxyvitamin D3, in lowering cholesterol in hypercholesterolemic micein vivo

Autor: Paola Bukuroshi, Tamara Dzekic, Holly P. Quach, K. Sandy Pang

Publikováno v: Biopharmaceutics & Drug Disposition. 39:196-204

Vitamin D3 and the synthetic vitamin D analogs, 1α-hydroxyvitamin D3 [1α(OH)D3 ], 1α-hydroxyvitamin D2 [1α(OH)D2 ] and 25-hydroxyvitamin D3 [25(OH)D3 ] were appraised for their vitamin D receptor (VDR) associated-potencies as cholesterol lowering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91d6d85ed3e44e1e5ce00a899d4e03e0
https://doi.org/10.1002/bdd.2126

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Highlighting Vitamin D Receptor–Targeted Activities of 1α,25-Dihydroxyvitamin D3in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling

Autor: Holly P. Quach, Edwin C. Y. Chow, K. Sandy Pang, Qi Joy Yang, Paola Bukuroshi

Publikováno v: Drug Metabolism and Disposition. 46:75-87

We expanded our published physiologically based pharmacokinetic model (PBPK) on 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], ligand of the vitamin D receptor (VDR), to appraise VDR-mediated pharmacodynamics in mice. Since 1,25(OH)2D3 kinetics was best d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84b34dec6404ecd7e3918f9f9ded37d5
https://doi.org/10.1124/dmd.117.077271

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