Výsledky vyhledávání - "Paola Ballesteros-Zebadua"

Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

Autor: Yasaman Alaghband, Barrett D. Allen, Eniko A. Kramár, Richard Zhang, Olivia G.G. Drayson, Ning Ru, Benoit Petit, Aymeric Almeida, Ngoc-Lien Doan, Marcelo A. Wood, Janet E. Baulch, Paola Ballesteros-Zebadua, Marie-Catherine Vozenin, Charles L. Limoli

Publikováno v: Cancer Research Communications. 3:725-737

Implementation of ultra-high dose-rate FLASH radiotherapy (FLASH-RT) is rapidly gaining traction as a unique cancer treatment modality able to dramatically minimize normal tissue toxicity while maintaining antitumor efficacy compared with standard-of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eae2291f38138db69f48e1b8a13c6648
https://doi.org/10.1158/2767-9764.crc-23-0117

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FIGURE 3 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

Autor: Charles L. Limoli, Marie-Catherine Vozenin, Paola Ballesteros-Zebadua, Janet E. Baulch, Marcelo A. Wood, Ngoc-Lien Doan, Aymeric Almeida, Benoit Petit, Ning Ru, Olivia G.G. Drayson, Richard Zhang, Eniko A. Kramár, Barrett D. Allen, Yasaman Alaghband

Mice exposed to FLASH-RT performed similar to controls in the NOR, LDB, and FE tests. A, NOR testing. Male mice exposed to FLASH-RT performed similar to controls, while CONV-RT were unable to differentiate between the familiar and novel object. Femal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b81440a4d33e6eee49e2c69ee07151
https://doi.org/10.1158/2767-9764.22709788.v1

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FIGURE 4 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

FLASH irradiation protects against reductions in LTP after CONV irradiation, 6 months after irradiation. A, Extended novel object recognition testing, 4 months after irradiation. Female mice that exposed to FLASH-RT performed significantly better tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57341eed1346c50f6c8b2e51c963fafb
https://doi.org/10.1158/2767-9764.22709785

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FIGURE 6 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

FLASH irradiation protected against prolonged inflammation found in CONV mice, 6 months after irradiation. Representative images of reactive microglia CD68 (red) and DAPI (blue) in the male mouse hippocampus (A) and representative images of IBA1 (gre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b595a2ecd95c6c2c545e9bbfd05d6133
https://doi.org/10.1158/2767-9764.22709779

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FIGURE 2 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

Mice exposed to FLASH-RT performed similar to controls in hippocampal-dependent learning and memory tests OUL while CONV-RT mice did not. A, Objects in updated locations testing experimental design. B, Update session behavior. At 4 months post-irradi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e092693241e38c6641fcc82442e8ba
https://doi.org/10.1158/2767-9764.22709791

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TABLE 1 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

Irradiation parameters. Fractionated whole brain irradiation was performed on the Oriatron 6e, 6-MeV electron beam LINAC at Lausanne University Hospital. Mice received three doses of 10 Gy separated by 48 hours using a 17 mm graphite applicator at ei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80005064abdc3c358c2fc02261043977
https://doi.org/10.1158/2767-9764.22709773

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FIGURE 1 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

Timeline. Ten-week-old mice received hypofractionated FLASH or CONV irradiation (3 × 10 Gy). A, Male and female mice underwent behavioral testing 4 months after irradiation. At 6 months post-irradiation, mice were sampled, and tissues were prepared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1297845d50a02b72f5368a58f69928ab
https://doi.org/10.1158/2767-9764.22709797.v1

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FIGURE 5 from Uncovering the Protective Neurologic Mechanisms of Hypofractionated FLASH Radiotherapy

FLASH irradiation protects synaptic density and spine morphology, 6 months after irradiation. A, Representative images of synaptophysin (red), DAPI (blue; Scale bar = 100 μm). B, Representative image of Homer1a (red)/Bassoon (green), respectively (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d120a85c8afa547a21010ff41a79322
https://doi.org/10.1158/2767-9764.22709782.v1

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Evaluation of the Gafchromic(®) EBT2 film for the dosimetry of radiosurgical beams

Autor: Jose M, Larraga-Gutierrez, Diana, Garcia-Hernandez, Olivia A, Garcia-Garduno, Olga O, Galvan de la Cruz, Paola, Ballesteros-Zebadua, Karina P, Esparza-Moreno

Publikováno v: Medical physics. 39(10)

Radiosurgery uses small fields and high-radiation doses to treat intra- and extracranial lesions in a single session. The lack of a lateral electronic equilibrium and the presence of high-dose gradients in these fields are challenges for adequate mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa6aca65646af6e3873d1f88976e3f1e
https://pubmed.ncbi.nlm.nih.gov/23039650

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Akademický článek

Chronic Consumption of Fructose Induces Behavioral Alterations by Increasing Orexin and Dopamine Levels in the Rat Brain

Autor: Javier Franco-Pérez, Joaquín Manjarrez-Marmolejo, Paola Ballesteros-Zebadúa, Adriana Neri-Santos, Sergio Montes, Norma Suarez-Rivera, Miguel Hernández-Cerón, Vadim Pérez-Koldenkova

Publikováno v: Nutrients, Vol 10, Iss 11, p 1722 (2018)

It has been widely described that chronic intake of fructose causes metabolic alterations which can be associated with brain function impairment. In this study, we evaluated the effects of fructose intake on the sleep⁻wake cycle, locomotion, and ne

Externí odkaz: https://doaj.org/article/4b464ff110e6417d8a4a7b160b6c0986

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