Výsledky vyhledávání - "Paola Menichini"

Akademický článek

Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells

Autor: Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Essam Nageh Sholkamy, Assem Barakat, Maurizio Viale, Paola Menichini, Andrea Speciale, Fabrizio Loiacono, Mohammad Azam, Ved Prakash Verma, Sammer Yousuf, Mohamed Teleb

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-23 (2023)

Abstract Recently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment. This directed efforts to invest in designing various combinatorial l

Externí odkaz: https://doaj.org/article/3163e75f3ed94e9b89596f628803db7b

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Akademický článek

The fading guardian: clinical relevance of TP53 null mutation in high-grade serous ovarian cancers

Autor: Chiara M. Biatta, Michele Paudice, Marco Greppi, Veronica Parrella, Alessia Parodi, Giuseppa De Luca, Gianna Maria Cerruti, Serafina Mammoliti, Cinzia Caroti, Paola Menichini, Gilberto Fronza, Silvia Pesce, Emanuela Marcenaro, Valerio G. Vellone

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Backgroundwe evaluated the concordance between immunohistochemical p53 staining and TP53 mutations in a series of HGSOC. Moreover, we searched for prognostic differences between p53 overexpression and null expression groups.Methodspatients affected b

Externí odkaz: https://doaj.org/article/9f4e5b0ac58246178fb58e2c8630fa81

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Akademický článek

PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis

Autor: Giulia Elda Valenti, Antonella Roveri, Rina Venerando, Paola Menichini, Paola Monti, Bruno Tasso, Nicola Traverso, Cinzia Domenicotti, Barbara Marengo

Publikováno v: Antioxidants, Vol 13, Iss 1, p 3 (2023)

Neuroblastoma (NB) is a paediatric cancer with noteworthy heterogeneity ranging from spontaneous regression to high-risk forms that are characterised by cancer relapse and the acquisition of drug resistance. The most-used anticancer drugs exert their

Externí odkaz: https://doaj.org/article/651feca5f0c3466cbdb9ac151cb59b07

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Akademický článek

Mutant p53K120R expression enables a partial capacity to modulate metabolism

Autor: Paola Monti, Silvia Ravera, Andrea Speciale, Irena Velkova, Giorgia Foggetti, Paolo Degan, Gilberto Fronza, Paola Menichini

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

The TP53 tumor suppressor gene is one of the most studied gene in virtue of its ability to prevent cancer development by regulating apoptosis, cell cycle arrest, DNA repair, autophagy and senescence. Furthermore, the modulation of metabolism by P53 i

Externí odkaz: https://doaj.org/article/7351ae7bb2af454c80afec635a00e923

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Akademický článek

Heterogeneity of TP53 Mutations and P53 Protein Residual Function in Cancer: Does It Matter?

Autor: Paola Monti, Paola Menichini, Andrea Speciale, Giovanna Cutrona, Franco Fais, Elisa Taiana, Antonino Neri, Riccardo Bomben, Massimo Gentile, Valter Gattei, Manlio Ferrarini, Fortunato Morabito, Gilberto Fronza

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

The human TP53 locus, located on the short arm of chromosome 17, encodes a tumour suppressor protein which functions as a tetrameric transcription factor capable of regulating the expression of a plethora of target genes involved in cell cycle arrest

Externí odkaz: https://doaj.org/article/b359c943d7f44811852f95eee85af7b6

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The spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study

Publikováno v: Hematological Oncology. 40:962-975

Chronic lymphocytic leukemia (CLL) is a hematological disorder with complex clinical and biological behavior. TP53 mutational status and cytogenetic assessment of the deletion of the corresponding locus (17p13.1) are considered the most relevant biom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0190d5872bd83fce69856b1559e833a8
https://doi.org/10.1002/hon.3063

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Akademický článek

Antitumor Effects of PRIMA-1 and PRIMA-1Met (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?

Autor: Paola Menichini, Paola Monti, Andrea Speciale, Giovanna Cutrona, Serena Matis, Franco Fais, Elisa Taiana, Antonino Neri, Riccardo Bomben, Massimo Gentile, Valter Gattei, Manlio Ferrarini, Fortunato Morabito, Gilberto Fronza

Publikováno v: Cells, Vol 10, Iss 1, p 98 (2021)

Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the TP53 tumor suppressor gene is a key player for cellular homeostasis. TP53 gene is mutated in more

Externí odkaz: https://doaj.org/article/67b53e7cbe394c809b68b9edf6e9e21c

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