Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Paola : Bonfanti"'
Autor:
Savvas Savvidis, Roberta Ragazzini, Valeria Conde de Rafael, J. Ciaran Hutchinson, Lorenzo Massimi, Fabio A. Vittoria, Sara Campinoti, Tom Partridge, Olumide K. Ogunbiyi, Alessia Atzeni, Neil J. Sebire, Paolo De Coppi, Alberto Mittone, Alberto Bravin, Paola Bonfanti, Alessandro Olivo
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-12 (2024)
Abstract Background The thymus, responsible for T cell-mediated adaptive immune system, has a structural and functional complexity that is not yet fully understood. Until now, thymic anatomy has been studied using histological thin sections or confoc
Externí odkaz:
https://doaj.org/article/46d78d1b44754c699d1b650dc9f7fdd6
Autor:
Sara A. Watson, Yousef Javanmardi, Luca Zanieri, Somayeh Shahreza, Roberta Ragazzini, Paola Bonfanti, Emad Moeendarbary
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)
Abstract The human thymus is the site of T‐cell maturation and induction of central tolerance. Hematopoietic stem cell (HSC)‐derived progenitors are recruited to the thymus from the fetal liver during early prenatal development and from bone marr
Externí odkaz:
https://doaj.org/article/2878d96b44214aec877e3a25719c7350
Autor:
Edward Hannon, Marco Pellegrini, Federico Scottoni, Natalie Durkin, Soichi Shibuya, Roberto Lutman, Toby J. Proctor, J. Ciaran Hutchinson, Owen J. Arthurs, Demetra-Ellie Phylactopoulos, Elizabeth F. Maughan, Colin R. Butler, Simon Eaton, Mark W. Lowdell, Paola Bonfanti, Luca Urbani, Paolo De Coppi
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105174- (2022)
Summary: Decellularization of esophagi from several species for tissue engineering is well described, but successful implantation in animal models of esophageal replacement has been challenging. The purpose of this study was to assess feasibility and
Externí odkaz:
https://doaj.org/article/e4991bd0c49541dc872eda47ebf1df19
Autor:
Sara Campinoti, Asllan Gjinovci, Roberta Ragazzini, Luca Zanieri, Linda Ariza-McNaughton, Marco Catucci, Stefan Boeing, Jong-Eun Park, John C. Hutchinson, Miguel Muñoz-Ruiz, Pierluigi G. Manti, Gianluca Vozza, Carlo E. Villa, Demetra-Ellie Phylactopoulos, Constance Maurer, Giuseppe Testa, Hans J. Stauss, Sarah A. Teichmann, Neil J. Sebire, Adrian C. Hayday, Dominique Bonnet, Paola Bonfanti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tis
Externí odkaz:
https://doaj.org/article/c841855db99048c2a21529c2cdc906b1
Autor:
Stéphanie Claudinot, Jun-Ichi Sakabe, Hideo Oshima, Christèle Gonneau, Thimios Mitsiadis, Daniel Littman, Paola Bonfanti, Geert Martens, Michael Nicolas, Ariane Rochat, Yann Barrandon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Adult stem cells are thought to be fate restricted to lineages distinct to their tissue of origin. Here, the authors demonstrate that Tp63 expressing epithelial stem cells from several disparate tissues can respond to skin morphogenetic signals and c
Externí odkaz:
https://doaj.org/article/be9d6acf12fb439aa5de18cc8884d19d
Autor:
Giovanni Giuseppe Giobbe, Claire Crowley, Camilla Luni, Sara Campinoti, Moustafa Khedr, Kai Kretzschmar, Martina Maria De Santis, Elisa Zambaiti, Federica Michielin, Laween Meran, Qianjiang Hu, Gijs van Son, Luca Urbani, Anna Manfredi, Monica Giomo, Simon Eaton, Davide Cacchiarelli, Vivian S. W. Li, Hans Clevers, Paola Bonfanti, Nicola Elvassore, Paolo De Coppi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formati
Externí odkaz:
https://doaj.org/article/a28b06f5539f456b97162079de3a5a5a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Inborn errors of thymic stromal cell development and function lead to impaired T-cell development resulting in a susceptibility to opportunistic infections and autoimmunity. In their most severe form, congenital athymia, these disorders are life-thre
Externí odkaz:
https://doaj.org/article/913f344678b241a1a1585579c1d1db17
Autor:
Luca Urbani, Carlotta Camilli, Demetra-Ellie Phylactopoulos, Claire Crowley, Dipa Natarajan, Federico Scottoni, Panayiotis Maghsoudlou, Conor J. McCann, Alessandro Filippo Pellegata, Anna Urciuolo, Koichi Deguchi, Sahira Khalaf, Salvatore Ferdinando Aruta, Maria Cristina Signorelli, David Kiely, Edward Hannon, Matteo Trevisan, Rui Rachel Wong, Marc Olivier Baradez, Dale Moulding, Alex Virasami, Asllan Gjinovci, Stavros Loukogeorgakis, Sara Mantero, Nikhil Thapar, Neil Sebire, Simon Eaton, Mark Lowdell, Giulio Cossu, Paola Bonfanti, Paolo De Coppi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Combining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oe
Externí odkaz:
https://doaj.org/article/04035db7e1a6472b9d4fc0a2bd25b51a
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 139-150 (2017)
Abstract More than 40 years ago, Howard Green's laboratory developed a method for long‐term expansion of primary human epidermal keratinocytes by co‐culture with 3T3 mouse embryonic fibroblasts. This was a breakthrough for in vitro cultivation of
Externí odkaz:
https://doaj.org/article/a3df8cc72dc746c38dfea7f62971a93e
Autor:
Dejan Mesner, Ann-Kathrin Reuschl, Matthew V. X. Whelan, Taylor Bronzovich, Tafhima Haider, Lucy G. Thorne, Roberta Ragazzini, Paola Bonfanti, Greg J. Towers, Clare Jolly
SARS-CoV-2 spike requires proteolytic processing for viral entry. A polybasic furin-cleavage site (FCS) in spike, and evolution toward an optimized FCS by dominant variants of concern (VOCs), are linked to enhanced infectivity and transmission. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe5d2a0a9a1b47d0432724e0d14b45e
