Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Paola, Picotti"'
Autor:
Rebekka Wegmann, Lorenz Bankel, Yasmin Festl, Kate Lau, Sohyon Lee, Fabian Arnold, Valentina Cappelletti, Aaron Fehr, Paola Picotti, Konstantin J. Dedes, Daniel Franzen, Daniela Lenggenhager, Peter K. Bode, Martin Zoche, Holger Moch, Christian Britschgi, Berend Snijder
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Personalized treatment for patients with advanced solid tumors critically depends on the deep characterization of tumor cells from patient biopsies. Here, we comprehensively characterize a pan-cancer cohort of 150 malignant serous effusion (
Externí odkaz:
https://doaj.org/article/6040e8b387b24847845fb184ce64f893
Autor:
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre PA Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2024-2042 (2024)
Abstract Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer’s disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused b
Externí odkaz:
https://doaj.org/article/361701b3ccf5457e8ccf997a37e06f01
Autor:
Xinyue Ding, Simone Aureli, Anand Vaithia, Pia Lavriha, Dina Schuster, Basavraj Khanppnavar, Xiaodan Li, Thorsten B. Blum, Paola Picotti, Francesco L. Gervasio, Volodymyr M. Korkhov
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/6d8c7a3f62634a05b3d02d16dab59e5a
Autor:
Aleš Holfeld, Dina Schuster, Fabian Sesterhenn, Alison K Gillingham, Patrick Stalder, Walther Haenseler, Inigo Barrio-Hernandez, Dhiman Ghosh, Jane Vowles, Sally A Cowley, Luise Nagel, Basavraj Khanppnavar, Tetiana Serdiuk, Pedro Beltrao, Volodymyr M Korkhov, Sean Munro, Roland Riek, Natalie de Souza, Paola Picotti
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 651-675 (2024)
Abstract The physical interactome of a protein can be altered upon perturbation, modulating cell physiology and contributing to disease. Identifying interactome differences of normal and disease states of proteins could help understand disease mechan
Externí odkaz:
https://doaj.org/article/111e459619b140979ac5a006ab8a5025
Autor:
Lukas Frey, Dhiman Ghosh, Bilal M Qureshi, David Rhyner, Ricardo Guerrero-Ferreira, Aditya Pokharna, Witek Kwiatkowski, Tetiana Serdiuk, Paola Picotti, Roland Riek, Jason Greenwald
Publikováno v:
eLife, Vol 12 (2024)
The aggregation of the protein α-synuclein is closely associated with several neurodegenerative disorders and as such the structures of the amyloid fibril aggregates have high scientific and medical significance. However, there are dozens of unique
Externí odkaz:
https://doaj.org/article/b3148a9d0d8343938297881e5df6743e
Autor:
Monika Pepelnjak, Rivkah Rogawski, Galina Arkind, Yegor Leushkin, Irit Fainer, Gili Ben-Nissan, Paola Picotti, Michal Sharon
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 4, Pp 403-427 (2024)
Abstract For years, proteasomal degradation was predominantly attributed to the ubiquitin-26S proteasome pathway. However, it is now evident that the core 20S proteasome can independently target proteins for degradation. With approximately half of th
Externí odkaz:
https://doaj.org/article/2a18edd0175d45c28478f28b1ded6b6d
Autor:
Matthias Weith, Jan Großbach, Mathieu Clement‐Ziza, Ludovic Gillet, María Rodríguez‐López, Samuel Marguerat, Christopher T Workman, Paola Picotti, Jürg Bähler, Ruedi Aebersold, Andreas Beyer
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 8, Pp 1-21 (2023)
Abstract The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules,
Externí odkaz:
https://doaj.org/article/4f972d70022840c5813a7645a1b8d926
Autor:
Chao Qi, Silvia Acosta Gutierrez, Pia Lavriha, Alaa Othman, Diego Lopez-Pigozzi, Erva Bayraktar, Dina Schuster, Paola Picotti, Nicola Zamboni, Mario Bortolozzi, Francesco Luigi Gervasio, Volodymyr M Korkhov
Publikováno v:
eLife, Vol 12 (2023)
Gap junction channels (GJCs) mediate intercellular communication by connecting two neighbouring cells and enabling direct exchange of ions and small molecules. Cell coupling via connexin-43 (Cx43) GJCs is important in a wide range of cellular process
Externí odkaz:
https://doaj.org/article/54524b1aa5d145ec93aa0146ef626473
Autor:
Michal Grzmil, Paul Boersema, Ashish Sharma, Alain Blanc, Stefan Imobersteg, Martin Pruschy, Paola Picotti, Roger Schibli, Martin Behe
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged from studies using external beam radiation therapy (EBRT). Yet, less is known about the cancer response to internal tar
Externí odkaz:
https://doaj.org/article/bac256bf9020417aa488a6d6235cc1ac
Autor:
Ved Mehta, Basavraj Khanppnavar, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M Korkhov
Publikováno v:
eLife, Vol 11 (2022)
Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function. Although the vital role of ACs in cellular signalling is well estab
Externí odkaz:
https://doaj.org/article/6a21e41f8fdc4cd79054b568a5329337