Zobrazeno 1 - 10 of 242 pro vyhledávání: '"Paola, Grandi"'
1
Akademický článek
Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages
Autor: Hung-Jen Chen, Daniel C. Sévin, Guillermo R. Griffith, Johanna Vappiani, Lee M. Booty, Cindy P.A.A. van Roomen, Johan Kuiper, Jeroen den Dunnen, Wouter J. de Jonge, Rab K. Prinjha, Palwinder K. Mander, Paola Grandi, Beata S. Wyspianska, Menno P.J. de Winther
Publikováno v: Cell Reports, Vol 43, Iss 9, Pp 114741- (2024)
Summary: Macrophages exhibit diverse phenotypes and respond flexibly to environmental cues through metabolic remodeling. In this study, we present a comprehensive multi-omics dataset integrating intra- and extracellular metabolomes with transcriptomi
Externí odkaz: https://doaj.org/article/ae89bd3f7a5c4e6f9f0d1640e1046c34
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2
Akademický článek
Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition
Autor: Mira L Burtscher, Stephan Gade, Martin Garrido-Rodriguez, Anna Rutkowska, Thilo Werner, H Christian Eberl, Massimo Petretich, Natascha Knopf, Katharina Zirngibl, Paola Grandi, Giovanna Bergamini, Marcus Bantscheff, Maria Fälth-Savitski, Julio Saez-Rodriguez
Publikováno v: Molecular Systems Biology, Vol 20, Iss 4, Pp 458-474 (2024)
Abstract Complex disease phenotypes often span multiple molecular processes. Functional characterization of these processes can shed light on disease mechanisms and drug effects. Thermal Proteome Profiling (TPP) is a mass-spectrometry (MS) based tech
Externí odkaz: https://doaj.org/article/6a429efa9e5f4ec6975418af5d3be112
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3
Akademický článek
Fermi-LAT Detection of the Low-luminosity Radio Galaxy NGC 4278 during the LHAASO Campaign
Autor: Ettore Bronzini, Paola Grandi, Eleonora Torresi, Sara Buson
Publikováno v: The Astrophysical Journal Letters, Vol 977, Iss 1, p L16 (2024)
We present a study of the high-energy properties of the compact symmetric object NGC 4278, recently associated with a TeV source by the Large High Altitude Air Shower Observatory (LHAASO) collaboration. We conducted a dedicated analysis of a Fermi La
Externí odkaz: https://doaj.org/article/3827d28e6e454a1fb565332a3ad12923
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6
Akademický článek
GBM-Targeted oHSV Armed with Matrix Metalloproteinase 9 Enhances Anti-tumor Activity and Animal Survival
Autor: Paola Sette, Nduka Amankulor, Aofei Li, Marco Marzulli, Daniela Leronni, Mingdi Zhang, William F. Goins, Balveen Kaur, Chelsea Bolyard, Timothy P. Cripe, Jianhua Yu, E. Antonio Chiocca, Joseph C. Glorioso, Paola Grandi
Publikováno v: Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 214-222 (2019)
The use of mutant strains of oncolytic herpes simplex virus (oHSV) in early-phase human clinical trials for the treatment of glioblastoma multiforme (GBM) has proven safe, but limited efficacy suggests that more potent vector designs are required for
Externí odkaz: https://doaj.org/article/5f4315ec1f9e411f9c37060adda0a50a
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7
Akademický článek
Updates on Oncolytic Virus Immunotherapy for Cancers
Autor: Cole Peters, Paola Grandi, Fares Nigim
Publikováno v: Molecular Therapy: Oncolytics, Vol 12, Iss , Pp 259-262 (2019)
The 2018 annual Cambridge Healthtech Institute’s International Immuno-Oncology Summit in Boston, MA convened late August, and academic and industry researchers were allowed to debate and discuss oncolytic virology during the virus immunotherapy por
Externí odkaz: https://doaj.org/article/23e6514568f840bdb86b31938581e935
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9
Akademický článek
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
Autor: Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S. Gadd, Katarzyna M. Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D. Read, Doreen A. Cantrell, Sonia Rocha, Alessio Ciulli
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Small molecule probes used to trigger hypoxic response by activating hypoxia inducible factors (HIFs) often lack specificity. Here the authors report a potent small molecule inhibitor that induces hypoxic response by blocking VHL:HIF interactions, pr
Externí odkaz: https://doaj.org/article/3040359d09be44dd8ac2502767cf24e9
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