Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paola, De Giorgio"'
Autor:
Marcello Leopoldo, Francesco Berardi, Grzegorz Satała, Roberto Perrone, Beata Duszyńska, Enza Lacivita, Andrzej J. Bojarski, Mauro Niso, Daniela Patarnello, Nicola Antonio Colabufo, Paola De Giorgio
Publikováno v:
Experimental Brain Research. 230:569-582
Serotonin 7 (5-hydroxytryptamine7 or 5-HT7) is the most recently identified serotonin receptor. It is involved in mood disorders and is studied as a target for antidepressants. Here, we report on the structural manipulation of the 5-HT7 receptor liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c464263d99878f8bd1f174075aa6c7
https://doi.org/10.1007/s00221-013-3498-0
https://doi.org/10.1007/s00221-013-3498-0
Autor:
Enza, Lacivita, Ermelinda, Lucente, Chantal, Kwizera, Ines F, Antunes, Mauro, Niso, Paola, De Giorgio, Roberto, Perrone, Nicola A, Colabufo, Philip H, Elsinga, Marcello, Leopoldo
Publikováno v:
Bioorganicmedicinal chemistry. 25(1)
Gastrin-releasing peptide receptors (GRP-Rs, also known as bombesin 2 receptors) are overexpressed in a variety of human cancers, including prostate cancer, and therefore they represent a promising target for in vivo imaging of tumors using positron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::170fcf3ccb1d51a6b2a22606474efe6f
https://pubmed.ncbi.nlm.nih.gov/27863916
https://pubmed.ncbi.nlm.nih.gov/27863916
Autor:
Paola De Giorgio, Nicola Antonio Colabufo, Francesco Berardi, Enza Lacivita, Marcello Leopoldo, Roberto Perrone, Pantaleo Di Pilato
Publikováno v:
Expert Opinion on Therapeutic Patents. 22:887-902
Introduction: The 5-HT1A receptors are implicated in mood disorders (anxiety, depression), in cognition, and in modulation of pain. Nearly 30 years of research in this field, there is still interest in developing new chemical entities capable of 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12d89cc6e7bc94af727ec7dfbf3ad27
https://doi.org/10.1517/13543776.2012.703654
https://doi.org/10.1517/13543776.2012.703654
Autor:
Per Svenningsson, Marcello Leopoldo, Antonia Caroli, Daniela Patarnello, Nicola Antonio Colabufo, Peter B. Hedlund, Pantaleo Di Pilato, Nikolas Stroth, Paola De Giorgio, Mauro Niso, Enza Lacivita, Francesco Berardi, Marialessandra Contino, Roberto Perrone
Publikováno v:
Journal of Medicinal Chemistry. 55:6375-6380
Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f30904e6fd1b25ea2f0dfa51e4eb3c2
https://doi.org/10.1021/jm3003679
https://doi.org/10.1021/jm3003679
Autor:
Enza Lacivita, Marialessandra Contino, Paola De Giorgio, Francesco Berardi, Roberto Perrone, Marcello Leopoldo
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:758-766
In the search for compounds with potential for development as positron emission tomography radioligands for brain D 3 receptor imaging, a series of N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides with appropriate lipophilicity (2 < log P < 3.5) wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2654cde1e3d787f02b4843cd185a74ec
https://doi.org/10.1016/j.bmc.2008.11.044
https://doi.org/10.1016/j.bmc.2008.11.044
Autor:
Marcello Leopoldo, Roberto Perrone, Francesco Berardi, Mauro Niso, Paola De Giorgio, Nicola Antonio Colabufo, Enza Lacivita
Publikováno v:
Journal of Medicinal Chemistry. 49:358-365
We here report the synthesis of compounds structurally related to the high-affinity dopamine D(3) receptor ligand N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-7-methoxy-2-benzofurancarboxamide (1). All compounds were specifically designed as pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d9142b820f0741a5fde2c5c5edb9ca
https://doi.org/10.1021/jm050734s
https://doi.org/10.1021/jm050734s
Autor:
Matthias M. Herth, Mauro Niso, Agnete Dyssegaard, Roberto Perrone, Szabolcs Lehel, Paola De Giorgio, Nicola Antonio Colabufo, Marcello Leopoldo, Gitte M. Knudsen, Francesco Berardi, Valdemar L. Andersen, Anders Ettrup, Enza Lacivita, Pantaleo Di Pilato, Hanne D. Hansen
Publikováno v:
European journal of medicinal chemistry. 79
In the search for a novel serotonin 7 (5-HT 7 ) receptor PET radioligand we synthesized and evaluated a new series of biphenylpiperazine derivatives in vitro . Among the studied compounds, ( R )-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8176a26037d11bf38f1f4433c06584
https://pubmed.ncbi.nlm.nih.gov/24732791
https://pubmed.ncbi.nlm.nih.gov/24732791
Autor:
Paola De Giorgio, Marcello Leopoldo, Roberto Perrone, Mauro Niso, Enza Lacivita, Nicola Antonio Colabufo, Francesco Berardi
Publikováno v:
Chemistrybiodiversity. 11(2)
We report the synthesis of compounds structurally related to the high-affinity dopamine D4 receptor ligand N-{2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl}-3-methoxybenzamide (1e). All compounds were specifically designed as potential PET radioliga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c2123d9f215adbd516770a655017ed
https://pubmed.ncbi.nlm.nih.gov/24591318
https://pubmed.ncbi.nlm.nih.gov/24591318
Autor:
Liliya N. Kirpotina, Ermelinda Lucente, Marcello Leopoldo, Igor A. Schepetkin, Enza Lacivita, Paola De Giorgio, Andrei I. Khlebnikov, Mark T. Quinn
Publikováno v:
Biochemical pharmacology. 85(3)
N-formyl peptide receptors (FPRs) are G protein-coupled receptors (GPCRs) that play critical roles in inflammatory reactions, and FPR-specific interactions can possibly be used to facilitate the resolution of pathological inflammatory reactions. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550d47a072288556abe7e8ec9f73ca09
https://pubmed.ncbi.nlm.nih.gov/23219934
https://pubmed.ncbi.nlm.nih.gov/23219934
Publikováno v:
5-HT2C Receptors in the Pathophysiology of CNS Disease ISBN: 9781607619406
Over the past 15 years, there have been various attempts to rationally develop selective ligands for serotonin 5-HT2C receptor subtypes. To this end, the studies performed by researchers at GlaxoSmithKline have led to the identification of several po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea6c63c8078510ff37cadb7e2db30fcc
https://doi.org/10.1007/978-1-60761-941-3_3
https://doi.org/10.1007/978-1-60761-941-3_3
