Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Paola, Circosta"'
Autor:
Mohammad Houshmand, Nicoletta Vitale, Francesca Orso, Alessandro Cignetti, Ivan Molineris, Valentina Gaidano, Stefano Sainas, Marta Giorgis, Donatella Boschi, Carmen Fava, Alice Passoni, Marta Gai, Massimo Geuna, Federica Sora, Alessandra Iurlo, Elisabetta Abruzzese, Massimo Breccia, Olga Mulas, Giovanni Caocci, Fausto Castagnetti, Daniela Taverna, Salvatore Oliviero, Fabrizio Pane, Marco Lucio Lolli, Paola Circosta, Giuseppe Saglio
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-13 (2022)
Abstract The development of different generations of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has led to the high overall survival of chronic myeloid leukemia (CML) patients. However, there are CML patients who show resistance to TKI therapy and ar
Externí odkaz:
https://doaj.org/article/8b9664dc6202406c8f68c1be24352acf
Autor:
Mohammad Houshmand, Alireza Kazemi, Ali Anjam Najmedini, Muhammad Shahzad Ali, Valentina Gaidano, Alessandro Cignetti, Carmen Fava, Daniela Cilloni, Giuseppe Saglio, Paola Circosta
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 24, p 5805 (2021)
Chronic myeloid leukemia stem cells (CML LSCs) are a rare and quiescent population that are resistant to tyrosine kinase inhibitors (TKI). When TKI therapy is discontinued in CML patients in deep, sustained and apparently stable molecular remission,
Externí odkaz:
https://doaj.org/article/0815e0350a3d40169f4ed9edd15f0b46
Autor:
Paola Circosta, Chiara Donini, Susanna Gallo, Lidia Giraudo, Loretta Gammaitoni, Ramona Rotolo, Federica Galvagno, Sonia Capellero, Marco Basiricò, Monica Casucci, Massimo Aglietta, Ivana Ferrero, Franca Fagioli, Alessandro Cignetti, Fabrizio Carnevale‐Schianca, Valeria Leuci, Dario Sangiolo
Publikováno v:
British Journal of Haematology. 200:64-69
Autor:
Stefano Sainas, Marta Giorgis, Paola Circosta, Giulio Poli, Marta Alberti, Alice Passoni, Valentina Gaidano, Agnese C. Pippione, Nicoletta Vitale, Davide Bonanni, Barbara Rolando, Alessandro Cignetti, Cristina Ramondetti, Alessia Lanno, Davide M. Ferraris, Barbara Canepa, Barbara Buccinnà, Marco Piccinini, Menico Rizzi, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Riccardo Miggiano, Tiziano Tuccinardi, Marco L. Lolli
Publikováno v:
Journal of Medicinal Chemistry. 65:12701-12724
Autor:
Mohammad Houshmand, Francesca Garello, Rachele Stefania, Valentina Gaidano, Alessandro Cignetti, Michela Spinelli, Carmen Fava, Mahin Nikougoftar Zarif, Sara Galimberti, Ester Pungolino, Mario Annunziata, Luigia Luciano, Giorgina Specchia, Monica Bocchia, Gianni Binotto, Massimiliano Bonifacio, Bruno Martino, Patrizia Pregno, Fabio Stagno, Alessandra Iurlo, Sabina Russo, Silvio Aime, Paola Circosta, Giuseppe Saglio
Publikováno v:
Cancers, Vol 13, Iss 6, p 1311 (2021)
CML is a hematopoietic stem-cell disorder emanating from breakpoint cluster region/Abelson murine leukemia 1 (BCR/ABL) translocation. Introduction of different TKIs revolutionized treatment outcome in CML patients, but CML LSCs seem insensitive to TK
Externí odkaz:
https://doaj.org/article/0a896ef93d264e3eb697531571e1d565
Autor:
Valentina Gaidano, Mohammad Houshmand, Nicoletta Vitale, Giovanna Carrà, Alessandro Morotti, Valerio Tenace, Stefania Rapelli, Stefano Sainas, Agnese Chiara Pippione, Marta Giorgis, Donatella Boschi, Marco Lucio Lolli, Daniela Cilloni, Alessandro Cignetti, Giuseppe Saglio, Paola Circosta
Publikováno v:
Cancers, Vol 13, Iss 5, p 1003 (2021)
Dihydroorotate Dehydrogenase (DHODH) is a key enzyme of the de novo pyrimidine biosynthesis, whose inhibition can induce differentiation and apoptosis in acute myeloid leukemia (AML). DHODH inhibitors had shown promising in vitro and in vivo activity
Externí odkaz:
https://doaj.org/article/6457d0266b1f4413a61306dc30ae7316
Autor:
Paola, Circosta, Chiara, Donini, Susanna, Gallo, Lidia, Giraudo, Loretta, Gammaitoni, Ramona, Rotolo, Federica, Galvagno, Sonia, Capellero, Marco, Basiricò, Monica, Casucci, Massimo, Aglietta, Ivana, Ferrero, Franca, Fagioli, Alessandro, Cignetti, Fabrizio, Carnevale-Schianca, Valeria, Leuci, Dario, Sangiolo
Cytokine-induced killer lymphocytes (CIK) are a promising alternative to conventional donor lymphocyte infusion (DLI), following allogeneic haematopoietic cell transplantation (HCT), due to their intrinsic anti-tumour activity and reduced risk of gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::670198723b323b780aed1a4131d4f912
https://hdl.handle.net/2318/1878042
https://hdl.handle.net/2318/1878042
Autor:
Mohammad Houshmand, Francesca Garello, Paola Circosta, Rachele Stefania, Silvio Aime, Giuseppe Saglio, Claudia Giachino
Publikováno v:
Nanomaterials, Vol 10, Iss 2, p 276 (2020)
Leukemia is a type of hematopoietic stem/progenitor cell malignancy characterized by the accumulation of immature cells in the blood and bone marrow. Treatment strategies mainly rely on the administration of chemotherapeutic agents, which, unfortunat
Externí odkaz:
https://doaj.org/article/0b7dc7f7178d4ad68927f0782bf9c5c6
Autor:
Paola Circosta, Angela Rita Elia, Indira Landra, Rodolfo Machiorlatti, Maria Todaro, Sabrina Aliberti, Davide Brusa, Silvia Deaglio, Sabina Chiaretti, Riccardo Bruna, Daniela Gottardi, Massimo Massaia, Filomena Di Giacomo, Anna Rita Guarini, Robin Foà, Peter W. Kyriakides, Rohan Bareja, Olivier Elemento, Gurunadh R. Chichili, Emanuele Monteleone, Paul A. Moore, Syd Johnson, Ezio Bonvini, Alessandro Cignetti, Giorgio Inghirami
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of h
Externí odkaz:
https://doaj.org/article/c9f24a2e69284c5786bd71c31922ae7b
Autor:
Marta Giorgis, Donatella Boschi, Barbara Buccinnà, Stefano Sainas, Mariia Mishina, Davide Bonanni, Alice Passoni, Salam Al-Karadaghi, Yaqi Qiu, Cristina Ramondetti, Paola Circosta, Giuseppe Saglio, Marco Piccinini, Valentina Gaidano, Mohammad Houshmand, Alessandro Bona, Alessandro Cignetti, Enrico Giraudo, Carina Florina Cojocaru, Marco Lucio Lolli, Barbara Rolando, Renzo Bagnati, Agnese Chiara Pippione, Barbara Canepa
Publikováno v:
Journal of Medicinal Chemistry. 64:5404-5428
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compou