Zobrazeno 1 - 10 of 81 pro vyhledávání: '"Paola, Chimenti"'
1
Akademický článek
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation
Autor: Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori, Claudiu T. Supuran
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1891-1905 (2020)
A large library of saccharin and acesulfame derivatives has been synthesised and evaluated against four isoforms of human carbonic anhydrase, the two off-targets hCA I/II and the tumour related isoforms hCA IX/XII. Different strategies of scaffold mo
Externí odkaz: https://doaj.org/article/78a54a75d73d42d58de2a564f1317cc7
Zobrazit plný text záznamu
2
Akademický článek
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity
Autor: Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso, Simone Carradori
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1511-1525 (2019)
A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPA
Externí odkaz: https://doaj.org/article/7280406604314cb88e2b4f9137207ce4
Zobrazit plný text záznamu
3
Akademický článek
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
Autor: Daniela Secci, Simone Carradori, Anél Petzer, Paolo Guglielmi, Melissa D’Ascenzio, Paola Chimenti, Donatella Bagetta, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 597-612 (2019)
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substitu
Externí odkaz: https://doaj.org/article/5a66b83f76a94eb594765e493cf83d5e
Zobrazit plný text záznamu
5
Akademický článek
Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives
Autor: Simone Carradori, Daniela Secci, Bruna Bizzarri, Paola Chimenti, Celeste De Monte, Paolo Guglielmi, Cristina Campestre, Daniela Rivanera, Claudia Bordón, Lorraine Jones-Brando
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 746-758 (2017)
We designed and synthesised novel N-substituted 1,3-thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii efficacy. This scaffold was functionalised both at the N1-hydrazine portion with three structurally different moietie
Externí odkaz: https://doaj.org/article/87d66fc2b0a447fd93bbae1c278f7042
Zobrazit plný text záznamu
7
Akademický článek
Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles
Autor: Paolo Guglielmi, Simone Carradori, Giulio Poli, Daniela Secci, Roberto Cirilli, Giulia Rotondi, Paola Chimenti, Anél Petzer, Jacobus P. Petzer
Publikováno v: Molecules, Vol 24, Iss 3, p 484 (2019)
New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral compounds were separated into their
Externí odkaz: https://doaj.org/article/4454e3dbe88d4979a5ac2e720f57987b
Zobrazit plný text záznamu
8
Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies
Autor: Virginia Pontecorvi, Mattia Mori, Francesca Picarazzi, Susi Zara, Simone Carradori, Amelia Cataldi, Andrea Angeli, Emanuela Berrino, Paola Chimenti, Alessia Ciogli, Daniela Secci, Paolo Guglielmi, Claudiu T. Supuran
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7950
Human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms IX and XII are overexpressed in solid hypoxic tumors, and they are considered as prognostic tools and therapeutic targets for cancer. Based on a molecular simplification of the well-known coumarin s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abadcc45759068bb33354d4812c26ab
https://pubmed.ncbi.nlm.nih.gov/35887299
Zobrazit plný text záznamu
9
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis
Autor: Gokhan Zengin, Melissa D'Ascenzio, Stefano Alcaro, Anél Petzer, Paolo Guglielmi, Daniela Secci, Simone Carradori, Francesco Ortuso, Jacobus P. Petzer, Paola Chimenti, Donatella Bagetta
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 597-612 (2019)
WOS: 000457961800001
PubMed: 30727777
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Dif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a6718bd21424aa2f15a4fb469c36fb
https://doi.org/10.1080/14756366.2019.1571272
Zobrazit plný text záznamu
10
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation
Autor: Andrea Angeli, Paolo Guglielmi, Simone Carradori, Giulia Rotondi, Alessandro Bonardi, Claudiu T. Supuran, Daniela Secci, Paola Chimenti, Alessio Nocentini, Paola Gratteri
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1891-1905 (2020)
A large library of saccharin and acesulfame derivatives has been synthesised and evaluated against four isoforms of human carbonic anhydrase, the two off-targets hCA I/II and the tumour related isoforms hCA IX/XII. Different strategies of scaffold mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a001d37adbf8a48d224036a97a66be
http://hdl.handle.net/11573/1449256
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje