Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Paola, Barraja"'
Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
Autor:
Mario Renda, Marilia Barreca, Anna Borrelli, Virginia Spanò, Alessandra Montalbano, Maria Valeria Raimondi, Roberta Bivacqua, Ilaria Musante, Paolo Scudieri, Daniela Guidone, Martina Buccirossi, Michele Genovese, Arianna Venturini, Tiziano Bandiera, Paola Barraja, Luis J. V. Galietta
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacologi
Externí odkaz:
https://doaj.org/article/a7ea66016c554c0992a26cad057a85ca
Autor:
Marilia Barreca, Noémie Lang, Chiara Tarantelli, Filippo Spriano, Paola Barraja, Francesco Bertoni
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 8, Pp 763-794 (2022)
Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting of tumor cells, compared to systemic cytotoxic chemotherapy. Their structure combines highly
Externí odkaz:
https://doaj.org/article/2ab29059a9fe48fda446247d32770b3e
Autor:
Marilia Barreca, Virginia Spanò, Maria Valeria Raimondi, Chiara Tarantelli, Filippo Spriano, Francesco Bertoni, Paola Barraja, Alessandra Montalbano
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 1, Iss , Pp 100004- (2021)
Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabeti
Externí odkaz:
https://doaj.org/article/19046b374f964d0bb7731ec2a44064d5
Autor:
Virginia Spanò, Marilia Barreca, Vincenzo Cilibrasi, Michele Genovese, Mario Renda, Alessandra Montalbano, Luis Juan Vicente Galietta, Paola Barraja
Publikováno v:
Molecules, Vol 26, Iss 5, p 1275 (2021)
Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del, causes misfolding and premature degradation of CFTR protein. This defect can be overcome with ph
Externí odkaz:
https://doaj.org/article/430009c87c074c6393fa99d7202ad584
Autor:
Marilia Barreca, Virginia Spanò, Alessandra Montalbano, Mercedes Cueto, Ana R. Díaz Marrero, Irem Deniz, Ayşegül Erdoğan, Lada Lukić Bilela, Corentin Moulin, Elisabeth Taffin-de-Givenchy, Filippo Spriano, Giuseppe Perale, Mohamed Mehiri, Ana Rotter, Olivier P. Thomas, Paola Barraja, Susana P. Gaudêncio, Francesco Bertoni
Publikováno v:
Marine Drugs, Vol 18, Iss 12, p 619 (2020)
The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestria
Externí odkaz:
https://doaj.org/article/eaf78dfe24d44eb3a3f870f759afa0a3
Autor:
Barbara Parrino, Anna Carbone, Gloria Di Vita, Cristina Ciancimino, Alessandro Attanzio, Virginia Spanò, Alessandra Montalbano, Paola Barraja, Luisa Tesoriere, Maria Antonia Livrea, Patrizia Diana, Girolamo Cirrincione
Publikováno v:
Marine Drugs, Vol 13, Iss 4, Pp 1901-1924 (2015)
A new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and the indole unit bound to position 2 of the thiazole ring was substituted by a 7-azaindole moiety, was efficiently synthesized. Two
Externí odkaz:
https://doaj.org/article/8d75a9ae9c604ffd94446f6f7c2fe963
Autor:
Anna Carbone, Barbara Parrino, Gloria Di Vita, Alessandro Attanzio, Virginia Spanò, Alessandra Montalbano, Paola Barraja, Luisa Tesoriere, Maria Antonia Livrea, Patrizia Diana, Girolamo Cirrincione
Publikováno v:
Marine Drugs, Vol 13, Iss 1, Pp 460-492 (2015)
Two new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and indole units were both substituted by 7-azaindole moieties or one indole unit was replaced by a 6-azaindole portion, were effici
Externí odkaz:
https://doaj.org/article/1aa3fe8515bc4b22be33d9bb487b99c2
Autor:
Manuela Labbozzetta, Marilia Barreca, Virginia Spanò, Maria Valeria Raimondi, Paola Poma, Monica Notarbartolo, Paola Barraja, Alessandra Montalbano
A series of [1,2]oxazolo[5,4‐e]isoindole derivatives was evaluated against HL‐60 cell line and its multidrug resistance (MDR) variant, HL‐60R, resistant to doxorubicin and to other P‐gp substrates by overexpressing the efflux pump. They displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3051a5f405d934b3372391e2315bf370
http://hdl.handle.net/10447/566082
http://hdl.handle.net/10447/566082
Autor:
Marilia Barreca, Angela Maria Ingarra, Maria Valeria Raimondi, Virginia Spanò, Antonio Palumbo Piccionello, Michele De Franco, Luca Menilli, Valentina Gandin, Giorgia Miolo, Paola Barraja, Alessandra Montalbano
Publikováno v:
Archives of pharmacal research. 45(11)
Nineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5H)-one and 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]aze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36713aa9256083af551b51057ae2054b
https://pubmed.ncbi.nlm.nih.gov/36399284
https://pubmed.ncbi.nlm.nih.gov/36399284
Synthesis of substituted isoindolo[2,1-a]quinoxalin-6-yl–amino and 6-imino-5-yl thiourea derivatives
Autor:
Barbara Parrino, Cristina Ciancimino, Chandrakant Sarwade, Virginia Spanò, Alessandra Montalbano, Paola Barraja, Girolamo Cirrincione, Patrizia Diana, Anna Carbone
Publikováno v:
ARKIVOC, Vol 2014, Iss 5, Pp 384-398 (2014)
Externí odkaz:
https://doaj.org/article/7aeb702456364ecf9cbedcf297220f46