An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration.

Autor: Leventhal MJ; MIT Ph.D. Program in Computational and Systems Biology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zanella CA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Kang B; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA., Peng J; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Gritsch D; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Liao Z; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Bukhari H; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wang T; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Present address: School of Computer Science, Northwestern Polytechnical University, Xi'an, China., Pao PC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Danquah S; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Benetatos J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Nehme R; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA.; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Farhi S; Spatial Technology Platform, Broad Institute of Harvard and MIT, Cambridge, MA USA., Tsai LH; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Dong X; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Scherzer CR; Precision Neurology Program, Brigham and Women's Hospital and Harvard Medical school, Boston, MA, USA.; APDA Center for Advanced Parkinson's Disease Research, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Present address: Stephen and Denise Adams Center of Yale School of Medicine, CT, USA., Feany MB; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Fraenkel E; MIT Ph.D. Program in Computational and Systems Biology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Lead contact.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 09. Date of Electronic Publication: 2024 Oct 09.

Multisensory gamma stimulation promotes glymphatic clearance of amyloid.

Autor: Murdock MH; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Yang CY; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Sun N; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pao PC; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Blanco-Duque C; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Kahn MC; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Kim T; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Lavoie NS; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Victor MB; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Islam MR; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Galiana F; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Leary N; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Wang S; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Bubnys A; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Ma E; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Akay LA; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Sneve M; Departments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Qian Y; Departments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Lai C; School of Life Sciences, Westlake University, Westlake Laboratory of Life Sciences and Biomedicine, and Westlake Institute for Advanced Study, Hangzhou, China., McCarthy MM; Department of Mathematics and Statistics, Boston University, Boston, MA, USA., Kopell N; Department of Mathematics and Statistics, Boston University, Boston, MA, USA., Kellis M; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Piatkevich KD; Departments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; School of Life Sciences, Westlake University, Westlake Laboratory of Life Sciences and Biomedicine, and Westlake Institute for Advanced Study, Hangzhou, China., Boyden ES; Departments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Tsai LH; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. lhtsai@mit.edu.

Publikováno v: Nature [Nature] 2024 Mar; Vol. 627 (8002), pp. 149-156. Date of Electronic Publication: 2024 Feb 28.

Ultrasound-guided puncture into newborn rat brain.

Autor: Ma RF; Institute of Neuroscience Kunming Medical University Kunming Yunnan China., Pao PC; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge Massachusetts USA., Zhang K; Institute of Ultrasound Shantou Ultrasonic Instrument Research Institute Co. Ltd. Shantou Guangdong China., Liu JX; Institute of Neuroscience Kunming Medical University Kunming Yunnan China., Zhang L; Department of Obstetrics, The International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China.

Publikováno v: Ibrain [Ibrain] 2023 May 10; Vol. 9 (4), pp. 359-368. Date of Electronic Publication: 2023 May 10 (Print Publication: 2023).

Histone Deacetylases 1 and 2 in Memory Function.

Autor: Pao PC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2022 Apr 06; Vol. 13 (7), pp. 848-858. Date of Electronic Publication: 2022 Mar 09.

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration.

Autor: Patnaik D; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Departments of Psychiatry & Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States., Pao PC; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Zhao WN; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Departments of Psychiatry & Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States., Silva MC; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Departments of Psychiatry & Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States., Hylton NK; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Departments of Psychiatry & Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States., Chindavong PS; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Departments of Psychiatry & Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States., Pan L; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Tsai LH; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Haggarty SJ; Chemical Neurobiology Laboratory, Center for Genomic Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States.; Departments of Psychiatry & Neurology, Massachusetts General Hospital & Harvard Medical School, Boston, Massachusetts 02114, United States.

Publikováno v: ACS chemical neuroscience [ACS Chem Neurosci] 2021 Jan 20; Vol. 12 (2), pp. 271-284. Date of Electronic Publication: 2021 Jan 08.