Mechanisms of Resistance to KRAS

Autor: Fiona H Blackhall, Colin R Lindsay, Victoria Dunnett-Kane, Pantelis A. Nicola

Publikováno v: Dunnett-kane, V, Nicola, P, Blackhall, F & Lindsay, C 2021, ' Mechanisms of Resistance to KRASG12C Inhibitors ', Cancers, vol. 13, no. 1, pp. 151 . https://doi.org/10.3390/cancers13010151
Cancers
Cancers, Vol 13, Iss 151, p 151 (2021)

Simple Summary KRAS is a gene that is commonly mutated in cancer, especially in pancreatic, lung and colorectal cancers. Despite its importance, scientists have for many years been unable to create a drug that can inhibit function of the KRAS protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa580c645b1d54f2cb06ef5569d0629a
https://pubmed.ncbi.nlm.nih.gov/33466360

Abstract B49: 'Triple wild-type' co-mutational profile in early-stage KRAS-mutant lung cancer

Autor: Sharzad Moghadam, Mathew Carter, Fiona H Blackhall, Andrew L. Wallace, Gareth A. Wilson, Charles Swanton, Colin R Lindsay, Pantelis A. Nicola, Mariam Jamal-Hanjani, William G. Newman, Robert G. Bristow, Katie Baker, George J Burghel, Eleanour Baker, Lynsey Priest, Jane Rogan, Helene Schlecht, Caroline Dive

Publikováno v: Molecular Cancer Research. 18:B49-B49

Introduction: Kirsten rat sarcoma viral oncogene (KRAS) is the most frequently mutated oncogene in non-small cell lung cancer (NSCLC), occurring in approximately 30% of cases. Recent work suggests KRAS -mutant (KRASm) NSCLC is a microcosm for diverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::995d7e5f5c6f0a752fdcb6d5f8f38c96
https://doi.org/10.1158/1557-3125.ras18-b49

Abstract 1763: Tumor mutational burden, mutational signatures and copy number variation in lung cancer driven by the Ras-Raf-MEK-ERK pathway

Autor: Helene Schlecht, Fiona H Blackhall, Mathew Carter, Lynsey Priest, George J Burghel, Colin R Lindsay, Eleanor Baker, Katie Baker, Jane Rogan, Pantelis A. Nicola, William G. Newman, Robert G. Bristow, Sharzad Moghadam, Andrew L. Wallace

Publikováno v: Cancer Research. 79:1763-1763

Introduction: Lung cancer is the most common cause of cancer-related death. Kirsten rat sarcoma viral oncogene (KRAS) is the most frequently mutated gene in non-small cell lung cancer (NSCLC), occurring in approximately 30% of cases. We characterised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dd2a19c44f8b97edda45177b5f3b880
https://doi.org/10.1158/1538-7445.am2019-1763