Multimodal prevention of first psychotic episode through N-acetyl-l-cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo-controlled, parallel-group trial

Autor: Schmidt, Stefanie J., Hurlemann, René, Schultz, Johannes, Wasserthal, Sven, Kloss, Christian, Maier, Wolfgang, Meyer-Lindenberg, Andreas, Hellmich, Martin, Muthesius-Digón, Ana, Pantel, Tanja, Wiesner, Pia-Sophie, Klosterkötter, Joachim, Ruhrmann, Stephan, ESPRIT-B1, Group

AIM Meta-analyses indicate positive effects of both antipsychotic and cognitive-behavioural interventions in subjects clinically at high risk (CHR) for psychosis in terms of a delay or prevention of psychotic disorders. However, these effects have be

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Multimodal prevention of first psychotic episode through N-acetyl-l-cysteine and integrated preventive psychological intervention in individuals clinically at high risk for psychosis: Protocol of a randomized, placebo-controlled, parallel-group trial.

Autor: Schmidt SJ; Department of Clinical Psychology and Psychotherapy, University of Bern, Bern, Switzerland.; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Hurlemann R; Department of Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Medical Psychology, University Hospital Bonn, Bonn, Germany., Schultz J; Department of Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Medical Psychology, University Hospital Bonn, Bonn, Germany., Wasserthal S; Department of Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Medical Psychology, University Hospital Bonn, Bonn, Germany., Kloss C; Department of Psychiatry, University Hospital Bonn, Bonn, Germany.; Division of Medical Psychology, University Hospital Bonn, Bonn, Germany., Maier W; Department of Psychiatry, University Hospital Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany., Meyer-Lindenberg A; Central Institute of Mental Health, Mannheim, Germany., Hellmich M; Institute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany., Muthesius-Digón A; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Pantel T; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Wiesner PS; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Klosterkötter J; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany., Ruhrmann S; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

Publikováno v: Early intervention in psychiatry [Early Interv Psychiatry] 2019 Dec; Vol. 13 (6), pp. 1404-1415. Date of Electronic Publication: 2019 Feb 19.