Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Panpan Hou"'
Autor:
Demin Ma, Yueming Zheng, Xiaoxiao Li, Xiaoyu Zhou, Zhenni Yang, Yan Zhang, Long Wang, Wenbo Zhang, Jiajia Fang, Guohua Zhao, Panpan Hou, Fajun Nan, Wei Yang, Nannan Su, Zhaobing Gao, Jiangtao Guo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-current, which helps to stabilize the membrane potential. KCNQ2 can be activated by analgesics and antiepileptic drugs but their activation mechanisms remain unclea
Externí odkaz:
https://doaj.org/article/9b35c0fc9ccb4882a2c41a9d66f6e062
Autor:
Panpan Hou, Dianyu Chen, Xuehui Wei, Xiaotao Hu, Xingwu Duan, Jingying Zhang, Lucheng Qiu, Linlin Zhang
Publikováno v:
Agricultural Water Management, Vol 288, Iss , Pp 108467- (2023)
Even though the process of plant water use under individual environmental stress conditions (drought, heat, cold, salinity, etc.) has been widely studied, the processes through which plants cope with multiple stresses (such as water stress combined w
Externí odkaz:
https://doaj.org/article/dc96e80a727948a7a5a594ab7e735c17
Publikováno v:
Pharmacological Research, Vol 192, Iss , Pp 106765- (2023)
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality, imposing an increasing global health burden. Cardiac ion channels (voltage-gated NaV, CaV, KVs, and others) synergistically shape the cardiac action potential (AP) and
Externí odkaz:
https://doaj.org/article/771442bc546b4349ad59eb1d7e897f5b
Autor:
Julian A. Schreiber, Melina Möller, Mark Zaydman, Lu Zhao, Zachary Beller, Sebastian Becker, Nadine Ritter, Panpan Hou, Jingyi Shi, Jon Silva, Eva Wrobel, Nathalie Strutz-Seebohm, Niels Decher, Nicole Schmitt, Sven G. Meuth, Martina Düfer, Bernhard Wünsch, Jianmin Cui, Guiscard Seebohm
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The binding site and mechanism of action for a benzodiazepine-derivative agonist on Kv7.1 channels is determined for drug development to treat long QT syndrome.
Externí odkaz:
https://doaj.org/article/bafac49ea4894bf6810ef9961c5fb7d7
Autor:
Yongfeng Liu, Xianjin Xu, Junyuan Gao, Moawiah M. Naffaa, Hongwu Liang, Jingyi Shi, Hong Zhan Wang, Nien-Du Yang, Panpan Hou, Wenshan Zhao, Kelli McFarland White, Wenjuan Kong, Alex Dou, Amy Cui, Guohui Zhang, Ira S. Cohen, Xiaoqin Zou, Jianmin Cui
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/eba1e156433146fcb46d508012928bbc
Autor:
Fan Xing, Jingshu Xiao, Junyu Wu, Jiaming Liang, Xiaoyu Lu, Liping Guo, Ping Li, Panpan Hou, Chunmei Li, Deyin Guo
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/5639578e4032402f9e46043648f1d025
Autor:
Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, Jianmin Cui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In voltage-gated potassium (KV) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that KV7.1 undergoes a two-stage E–M coupling mechanism duri
Externí odkaz:
https://doaj.org/article/35fb6ed5769147e193c27d6349310d60
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Externí odkaz:
https://doaj.org/article/0da5f32251a94f1c978a92f90a5f48ac
Autor:
Lang Bu, Huan Wang, Panpan Hou, Shuting Guo, Miao He, Jingshu Xiao, Ping Li, Yongheng Zhong, Penghui Jia, Yuanyuan Cao, Guanzhan Liang, Chenwei Yang, Lang Chen, Deyin Guo, Chun-Mei Li
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Innate immunity is the first-line defense against antiviral or antimicrobial infection. RIG-I and MDA5, which mediate the recognition of pathogen-derived nucleic acids, are essential for production of type I interferons (IFN). Here, we identified mit
Externí odkaz:
https://doaj.org/article/574aaba4aed94000a2e4880ac117eb50
Autor:
Keenan C Taylor, Po Wei Kang, Panpan Hou, Nien-Du Yang, Georg Kuenze, Jarrod A Smith, Jingyi Shi, Hui Huang, Kelli McFarland White, Dungeng Peng, Alfred L George, Jens Meiler, Robert L McFeeters, Jianmin Cui, Charles R Sanders
Publikováno v:
eLife, Vol 9 (2020)
Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three distinct conformations during activation: resting, intermediate, and activated. Experimental determination of the structure of a potassium channel VSD in the interme
Externí odkaz:
https://doaj.org/article/ee10c6d390644901b22e9bb15828c3d3