Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers

Autor: Renata Bordeira-Carriço, Joana Teixeira, Marta Duque, Mafalda Galhardo, Diogo Ribeiro, Rafael D. Acemel, Panos. N. Firbas, Juan J. Tena, Ana Eufrásio, Joana Marques, Fábio J. Ferreira, Telmo Freitas, Fátima Carneiro, José Luís Goméz-Skarmeta, José Bessa

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Alterations in cis-regulatory elements (CREs) can contribute to pancreatic diseases. Here the authors combine chromatin profiling and interaction points with in vivo reporter assays in zebrafish to uncover functionally equivalent human CREs, helping

Externí odkaz: https://doaj.org/article/1a526720f0e94a6eb3de65fc0179fea9

Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancers

Autor: Ana Eufrasio, Fátima Carneiro, Joana Marques, Joana Teixeira, Juan J. Tena, José Bessa, Diogo Ribeiro, José Luis Gómez-Skarmeta, Marta Duque, Telmo Freitas, Renata Bordeira-Carriço, Fábio J Ferreira, Rafael Dominguez-Acemel, Mafalda Galhardo, Panos N. Firbas

Publikováno v: bioRxiv

Introductory paragraphThe pancreas is a central organ for human diseases that have a dramatic societal burden, such as pancreatic cancer and diabetes1,2. Non-coding cis-regulatory elements (CREs) of DNA control gene expression3,4, being required for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ccd9dc058d59c54d889f8669e3c731
https://doi.org/10.1101/2020.04.27.064220

Ancient genomic regulatory blocks are a source for regulatory gene deserts in vertebrates after whole-genome duplications

Autor: Marta Silvia Magri, Juan J. Tena, Manuel Irimia, José Luis Gómez-Skarmeta, Rafael D. Acemel, Silvia Naranjo, María Touceda-Suárez, Panos N. Firbas, Elizabeth M. Kita, Ignacio Maeso

Publikováno v: Molecular Biology and Evolution
Digital.CSIC. Repositorio Institucional del CSIC
instname

The Author(s) 2020.
We investigated how the two rounds of whole-genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce0ca8964a35fa5560723cca7e1e3d9
http://hdl.handle.net/10230/45512

Ancient genomic regulatory blocks are a major source for gene deserts in vertebrates after whole genome duplications

Autor: Rafael D. Acemel, Silvia Naranjo, Juan J. Tena, Panos N. Firbas, Manuel Irimia, Ignacio Maeso, Elizabeth M. Kita, María Touceda-Suárez, José Luis Gómez-Skarmeta, Marta Silvia Magri

We investigated how the two rounds of whole genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic regulatory blocks, GRBs). We show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d439de662fe4e9d3be6aac5b55c579fb
https://doi.org/10.1101/776369

Amphioxus functional genomics and the origins of vertebrate gene regulation

Autor: Patrick Wincker, Pierre Pontarotti, Elisa de la Calle-Mustienes, Zbynek Kozmik, Malcolm Perry, José Luis Gómez-Skarmeta, Cristian Cañestro, Stéphanie Bertrand, Yamile Marquez, Èlia Benito-Gutiérrez, Juan J. Tena, Hector Escriva, Alexandra Louis, Anthony Leon, Matthew T. Weirauch, Juan Ramón Martínez-Morales, Panos N. Firbas, Peter W. H. Holland, Iryna Kozmikova, Daniel Aldea, Sandra Jiménez-Gancedo, Jordi Garcia-Fernàndez, Jean-Marc Aury, Michael Schubert, Paul Edward Duckett, Beatriz Albuixech-Crespo, Simon J. van Heeringen, Boris Lenhard, Piero Carninci, Carlos Herrera-Úbeda, Olivier Mirabeau, Demian Burguera, Lorena Buono, Tokiharu Takahashi, Rafael D. Acemel, Silvia Naranjo, Ryan Lister, Sophie Mangenot, Lucie Subirana, Ksenia Skvortsova, Jr-Kai Yu, Hugues Roest Crollius, Ildiko M. L. Somorjai, Vincent Laudet, Piotr J. Balwierz, Gabriel A. B. Marais, Ignacio Maeso, Anlong Xu, Christopher D. R. Wyatt, Shengfeng Huang, Ozren Bogdanovic, David E. K. Ferrier, Ferdinand Marlétaz, Salvatore D'Aniello, Jon Permanyer, Filipe Castro, Manuel Irimia, Ricard Albalat, Yann Le Petillon, Ensieh Farahani, Hervé Seitz

Publikováno v: Nature
Nature, 2018, 564 (7734), pp.64-70. ⟨10.1038/s41586-018-0734-6⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature, Nature Publishing Group, 2018, 564 (7734), pp.64-70. ⟨10.1038/s41586-018-0734-6⟩
Nature, 564, pp. 64-70
Digital.CSIC. Repositorio Institucional del CSIC
Dipòsit Digital de la UB
Universidad de Barcelona
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Nature, 564, 64-70
Takahashi, T & al, E 2018, ' Amphioxus functional genomics and the origins of vertebrate gene regulation ', Nature, vol. 564, pp. 64-70 . https://doi.org/10.1038/s41586-018-0734-6

Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome of the Mediterranean amphioxus (Branchiostoma lanceolatum) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4beca909ac1323255e03fa32b70757ff
https://hal.science/hal-02000511