Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

Autor: Dave T. Gerrard, Andrew A. Berry, Rachel E. Jennings, Matthew J. Birket, Peyman Zarrineh, Myles G. Garstang, Sarah L. Withey, Patrick Short, Sandra Jiménez-Gancedo, Panos N. Firbas, Ian Donaldson, Andrew D. Sharrocks, Karen Piper Hanley, Matthew E. Hurles, José Luis Gomez-Skarmeta, Nicoletta Bobola, Neil A. Hanley

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

How the epigenomic landscape linked to transcription regulates human embryonic development is unclear. Here, the authors analyse the dynamics of H3K27Ac, H3K4me3 and H3K27me3 during the period when organs first assemble as a platform for understandin

Externí odkaz: https://doaj.org/article/a296a0ec6d0e434aa7dff480689080a7

Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers

Autor: Renata Bordeira-Carriço, Joana Teixeira, Marta Duque, Mafalda Galhardo, Diogo Ribeiro, Rafael D. Acemel, Panos. N. Firbas, Juan J. Tena, Ana Eufrásio, Joana Marques, Fábio J. Ferreira, Telmo Freitas, Fátima Carneiro, José Luís Goméz-Skarmeta, José Bessa

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The pancreas is a central organ for human diseases. Most alleles uncovered by genome-wide association studies of pancreatic dysfunction traits overlap with non-coding sequences of DNA. Many contain epigenetic marks of cis-regulatory elements active i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e069c82c597b3e4f6171dea7a8eded5a
https://pubmed.ncbi.nlm.nih.gov/35410466

Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings

Autor: Ignacio Maeso, Carlos Vargas-Chávez, Ana Alcaina, Christopher D. R. Wyatt, Alex de Mendoza, Julio Rozas, Marta Gut, Jèssica Gómez-Garrido, Isabel Almudi, Bernhard Misof, Tyler Alioto, Panos N. Firbas, Stein Aerts, Ferdinand Marlétaz, Alejandro Sánchez-Gracia, Manuel Irimia, Patricia Medina, Roberto Feuda, Josefa González, Joel Vizueta, Ryan Lister, Giulio Masiero, Kristofer Davie, Fernando Cruz, Jordi Paps, Fernando Casares

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Almudi, I, Vizueta, J, Wyatt, C D R, de Mendoza, A, Marlétaz, F, Firbas, P N, Feuda, R, Masiero, G, Medina, P, Alcaina-Caro, A, Cruz, F, Gómez-Garrido, J, Gut, M, Alioto, T S, Vargas-Chavez, C, Davie, K, Misof, B, González, J, Aerts, S, Lister, R, Paps, J, Rozas, J, Sánchez-Gracia, A, Irimia, M, Maeso, I & Casares, F 2020, ' Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings ', Nature Communications, vol. 11, no. 1, 2631 . https://doi.org/10.1038/s41467-020-16284-8

The evolution of winged insects revolutionized terrestrial ecosystems and led to the largest animal radiation on Earth. However, we still have an incomplete picture of the genomic changes that underlay this diversification. Mayflies, as one of the si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395f695c89f56bc78a1eacd23740c424
http://hdl.handle.net/2445/178830

Genomic adaptations to aquatic and aerial life in mayflies and the origin of wings in insects

Autor: Bernhard Misof, Ignacio Maeso, Julio Rozas, Christopher D. R. Wyatt, Ana Alcaina, Giulio Masiero, Stein Aerts, Joel Vizueta, Carlos Vargas-Chávez, Josefa González, Kristofer Davie, Jèssica Gómez-Garrido, Jordi Paps, Fernando Cruz, Panos N. Firbas, Alejandro Sánchez-Gracia, Manuel Irimia, Patricia Medina, Alex de Mendoza, Marta Gut, Isabel Almudi, Tyler Alioto, Fernando Casares, Ryan Lister, Roberto Feuda, Ferdinand Marlétaz

The first winged insects underwent profound morphological and functional transformations leading to the most successful animal radiations in the history of earth. Despite this, we still have a very incomplete picture of the changes in their genomes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdd0e3c6e02fc7c51be84e45e88d5d4
https://doi.org/10.1101/2019.12.29.888636

The epigenomic landscape regulating organogenesis in human embryos linked to developmental disorders

Autor: José Luis Gómez-Skarmeta, Matthew E. Hurles, Dave T. Gerrard, Nicoletta Bobola, Neil A. Hanley, Patrick J. Short, Ian J. Donaldson, Panos N. Firbas, Matthew J. Birket, Andrew D. Sharrocks, Sandra Jiménez-Gancedo, Sarah J Withey, Karen Piper Hanley, Andrew Berry, Rachel E. Jennings

How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of in vitro stem cell differentiation or cell programming, or interpret the pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db67a3092c99b16783204f59f6c66d0c
https://doi.org/10.1101/691766