Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Panos Lehouritis"'
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180034 (2017)
Systemic administration of the highly potent anticancer therapeutic, tumour necrosis factor alpha (TNFα) induces high levels of toxicity and is responsible for serious side effects. Consequently, tumour targeting is required in order to confine this
Externí odkaz:
https://doaj.org/article/f4ab8ac4ca964b2280010faa4024a0bb
Publikováno v:
Journal of Controlled Release. 275:217-228
The ability to modify existing microbiota at different sites presents enormous potential for local or indirect management of various diseases. Because bacteria can be maintained for lengthy periods in various regions of the body, they represent a pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0795ce4df48bbeb117acc614b5e1d0
https://doi.org/10.1016/j.jconrel.2018.02.023
https://doi.org/10.1016/j.jconrel.2018.02.023
Publikováno v:
Advanced Drug Delivery Reviews. 118:8-23
Bacterial-directed enzyme prodrug therapy (BDEPT) is an emerging form of treatment for cancer. It is a biphasic variant of gene therapy in which a bacterium, armed with an enzyme that can convert an inert prodrug into a cytotoxic compound, induces tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61f69972fb4968a5d86180bdaf04c8b
https://doi.org/10.1016/j.addr.2017.09.012
https://doi.org/10.1016/j.addr.2017.09.012
Publikováno v:
Current Gene Therapy. 15:277-288
The feasibility of utilising bacteria as vectors for gene therapy is becoming increasingly recognised. This is primarily due to a number of intrinsic properties of bacteria such as their tumour targeting capabilities, their ability to carry large gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6548682b5f7c06101323f2a2a8cc1fa3
https://doi.org/10.2174/1566523215666150126122712
https://doi.org/10.2174/1566523215666150126122712
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180034 (2017)
PLoS ONE
PLoS ONE
Systemic administration of the highly potent anticancer therapeutic, tumour necrosis factor alpha (TNF alpha) induces high levels of toxicity and is responsible for serious side effects. Consequently, tumour targeting is required in order to confine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36d105ebe57b6038e6189ab6ed28501
https://hdl.handle.net/10468/4791
https://hdl.handle.net/10468/4791
Autor:
Florence O. McCarthy, William L. Byrne, Camilla Urbaniak, Michael Stanton, Panos Lehouritis, Mark Tangney, Carola T. Murphy, Joanne Cummins, Gregor Reid
Publikováno v:
Scientific Reports
Microbiology & Immunology Publications
Microbiology & Immunology Publications
In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and cancer cell lines were examined in vitro and in vivo for changes in the efficacy of cancer cell killing mediated by chemothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1ca15b91e4d9f2ef1879def3b9c401
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 222
Some chemotherapeutic drugs (prodrugs) require activation by an enzyme for efficacy. We and others have demonstrated the ability of probiotic bacteria to grow specifically within solid tumours following systemic administration, and we hypothesised th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5a7ccb97962f313539dcbd95d929fe
https://pubmed.ncbi.nlm.nih.gov/26655063
https://pubmed.ncbi.nlm.nih.gov/26655063
Publikováno v:
Current Medicinal Chemistry. 10:2175-2184
Regulation of expression in gene therapy is considered to be a very desirable goal, preventing toxic effects and improving biological efficacy. A variety of systems have been reported in an ever widening range of applications, this paper describes th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b2bf702a52765a916f4b0b8b46fb86
https://doi.org/10.2174/0929867033456837
https://doi.org/10.2174/0929867033456837
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 170(1)
Current conventional treatments for cancer lack tumour selectivity resulting in the destruction of healthy tissue and severe adverse effects to the patient in addition to limiting the administration dose and efficacy. Hence, it is imperative that we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee79344d21d8403c758b2028e75f2ed
https://pubmed.ncbi.nlm.nih.gov/23688772
https://pubmed.ncbi.nlm.nih.gov/23688772
Autor:
Mark Tangney, Sara Collins, Akihito Inagaki, Panos Lehouritis, Peter F. Searle, Christopher R. Logg, Noriyuki Kasahara, Shuichi Kamijima
Publikováno v:
Neuro-Oncology. 16:v81-v82
Our studies to date have demonstrated dramatic survival benefit when tumor-selective retroviral replicating vectors (RRV) are employed for prodrug activator gene therapy in a variety of preclinical cancer models. RRV-mediated gene therapy using yeast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abd2d322dfd1e6057b92acbab08d6fb
https://doi.org/10.1093/neuonc/nou255.13
https://doi.org/10.1093/neuonc/nou255.13