Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models.

Autor: Gough SM; Arvinas Operations, Inc., New Haven, Connecticut., Flanagan JJ; Arvinas Operations, Inc., New Haven, Connecticut., Teh J; Arvinas Operations, Inc., New Haven, Connecticut., Andreoli M; Arvinas Operations, Inc., New Haven, Connecticut., Rousseau E; Arvinas Operations, Inc., New Haven, Connecticut., Pannone M; Arvinas Operations, Inc., New Haven, Connecticut., Bookbinder M; Arvinas Operations, Inc., New Haven, Connecticut., Willard R; Arvinas Operations, Inc., New Haven, Connecticut., Davenport K; Arvinas Operations, Inc., New Haven, Connecticut., Bortolon E; Arvinas Operations, Inc., New Haven, Connecticut., Cadelina G; Arvinas Operations, Inc., New Haven, Connecticut., Gordon D; Arvinas Operations, Inc., New Haven, Connecticut., Pizzano J; Arvinas Operations, Inc., New Haven, Connecticut., Macaluso J; Arvinas Operations, Inc., New Haven, Connecticut., Soto L; Arvinas Operations, Inc., New Haven, Connecticut., Corradi J; Arvinas Operations, Inc., New Haven, Connecticut., Digianantonio K; Arvinas Operations, Inc., New Haven, Connecticut., Drulyte I; Thermo Fisher Scientific, Materials and Structural Analysis, Eindhoven, Netherlands., Morgan A; Arvinas Operations, Inc., New Haven, Connecticut., Quinn C; Arvinas Operations, Inc., New Haven, Connecticut., Békés M; Arvinas Operations, Inc., New Haven, Connecticut., Ferraro C; Arvinas Operations, Inc., New Haven, Connecticut., Chen X; Arvinas Operations, Inc., New Haven, Connecticut., Wang G; Arvinas Operations, Inc., New Haven, Connecticut., Dong H; Arvinas Operations, Inc., New Haven, Connecticut., Wang J; Arvinas Operations, Inc., New Haven, Connecticut., Langley DR; Arvinas Operations, Inc., New Haven, Connecticut., Houston J; Arvinas Operations, Inc., New Haven, Connecticut., Gedrich R; Arvinas Operations, Inc., New Haven, Connecticut., Taylor IC; Arvinas Operations, Inc., New Haven, Connecticut.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Aug 15; Vol. 30 (16), pp. 3549-3563.

Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells.

Autor: Neurauter CG; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, 0424, Norway; Centre for Embryology and Healthy Development, University of Oslo, Oslo, 0373, Norway. Electronic address: christine.gran@rr-research.no., Pannone M; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, 0424, Norway; Centre for Embryology and Healthy Development, University of Oslo, Oslo, 0373, Norway; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway. Electronic address: marco.pannone@ntnu.no., Sousa MML; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, 0424, Norway; Centre for Embryology and Healthy Development, University of Oslo, Oslo, 0373, Norway; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway. Electronic address: sousa@ntnu.no., Wang W; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway. Electronic address: wei.wang@ntnu.no., Kuśnierczyk A; Proteomics and Modomics Experimental Core Facility (PROMEC), Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway. Electronic address: anna.m.kusnierczyk@gmail.com., Luna L; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, 0424, Norway; Centre for Embryology and Healthy Development, University of Oslo, Oslo, 0373, Norway. Electronic address: luisa.luna@rr-research.no., Sætrom P; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway. Electronic address: pal.satrom@ntnu.no., Scheffler K; Department of Neurology, St.Olavs University Hospital, Trondheim, 7006, Norway; Department of Neuromedicine and Movement Science (INB), Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway. Electronic address: katja.scheffler@ntnu.no., Bjørås M; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, 0424, Norway; Centre for Embryology and Healthy Development, University of Oslo, Oslo, 0373, Norway; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), Trondheim, 7491, Norway. Electronic address: magnar.bjoras@ntnu.no.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2024 Mar; Vol. 213, pp. 470-487. Date of Electronic Publication: 2024 Jan 30.

A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment.

Autor: Lin X; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway., Wang W; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Yang M; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway.; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Damseh N; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine., de Sousa MML; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Jacob F; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Lång A; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway., Kristiansen E; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway., Pannone M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Kissova M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Almaas R; Department of Pediatric Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Kuśnierczyk A; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; The Proteomics and Metabolomics Core Facility (PROMEC), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Siller R; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Molecular Medicine, University of Oslo, Oslo, Norway., Shahrour M; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine.; Department of Newborn and Developmental Paediatrics, Toronto, ON, Canada., Al-Ashhab M; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine., Abu-Libdeh B; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine., Tang W; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Slupphaug G; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; The Proteomics and Metabolomics Core Facility (PROMEC), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Elpeleg O; Department of Genetics, Hadassah University Hospital, Jerusalem, Israel., Bøe SO; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway., Eide L; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway., Sullivan GJ; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Molecular Medicine, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway., Rinholm JE; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; The Proteomics and Metabolomics Core Facility (PROMEC), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Ming GL; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., van Loon B; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Edvardson S; Department of Genetics, Hadassah University Hospital, Jerusalem, Israel. SIMON@hadassah.org.il., Ye J; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway. jing.ye@ntnu.no., Bjørås M; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway. Magnar.Bjoras@ntnu.no.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway. Magnar.Bjoras@ntnu.no.; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway. Magnar.Bjoras@ntnu.no.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway. Magnar.Bjoras@ntnu.no.; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway. Magnar.Bjoras@ntnu.no.

Publikováno v: Genome biology [Genome Biol] 2023 Sep 29; Vol. 24 (1), pp. 216. Date of Electronic Publication: 2023 Sep 29.

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