Targeting aberrant replication and DNA repair events for treating breast cancers

Autor: Subapriya Rajamanickam, Jun Hyoung Park, Panneerdoss Subbarayalu, Santosh Timilsina, Kaitlyn Bates, Pooja Yadav, Saif S. R. Nirzhor, Vijay Eedunuri, Tabrez A. Mohammad, Kwang Hwa Jung, Benjamin Onyeagucha, Nourhan Abdelfattah, Raymond Benevides, Grace Lee, Yidong Chen, Ratna Vadlamudi, Andrew Brenner, Virginia Kaklamani, Ismail Jatoi, John Kuhn, Robert Hromas, Yogesh K. Gupta, Benny A. Kaipparettu, Jack L. Arbiser, Manjeet K. Rao

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)

A report of the small molecule Carbazole Blue demonstrates inhibition of breast cancer growth and metastasis without adverse effects on normal tissue.

Externí odkaz: https://doaj.org/article/7a4cae1b109747c5bf6ef01173eb2df8

M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression

Autor: Pooja Yadav, Panneerdoss Subbarayalu, Daisy Medina, Saif Nirzhor, Santosh Timilsina, Subapriya Rajamanickam, Vijay K. Eedunuri, Yogesh Gupta, Siyuan Zheng, Nourhan Abdelfattah, Yufei Huang, Ratna Vadlamudi, Robert Hromas, Paul Meltzer, Peter Houghton, Yidong Chen, Manjeet K. Rao

Publikováno v: Cancer Res

Osteosarcoma is the most common malignancy of the bone, yet the survival for patients with osteosarcoma is virtually unchanged over the past 30 years. This is principally because development of new therapies is hampered by a lack of recurrent mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d0cf6ab8b5422b36b185082225857e
https://doi.org/10.1158/0008-5472.can-21-2106

Data from M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression

Autor: Manjeet K. Rao, Yidong Chen, Peter Houghton, Paul Meltzer, Robert Hromas, Ratna Vadlamudi, Yufei Huang, Nourhan Abdelfattah, Siyuan Zheng, Yogesh Gupta, Vijay K. Eedunuri, Subapriya Rajamanickam, Santosh Timilsina, Saif Nirzhor, Daisy Medina, Panneerdoss Subbarayalu, Pooja Yadav

Osteosarcoma is the most common malignancy of the bone, yet the survival for patients with osteosarcoma is virtually unchanged over the past 30 years. This is principally because development of new therapies is hampered by a lack of recurrent mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a301a17d7ee9da4386f50cdab2d2538
https://doi.org/10.1158/0008-5472.c.6513931.v1

Animal Models of Gynecological Cancers

Autor: Prabhakar Pitta Venkata, Daisy Medina, Saif S. R. Nirzhor, Sivanandane Sittadjody, R. Ileng Kumaran, Ilangovan Ramachandran, Panneerdoss Subbarayalu

Publikováno v: Handbook of Animal Models and its Uses in Cancer Research ISBN: 9789811938238
Handbook of Animal Models and its Uses in Cancer Research ISBN: 9789811912825

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3528291fa48b744b0518e02d437b529f
https://doi.org/10.1007/978-981-19-3824-5_18

Abstract 3528: ALKBH5 promotes cancer growth by regulating ER homeostasis via UPR, autophagy, and mitochondrial function

Autor: Panneerdoss Subbarayalu, Daisy Medina, Pooja Yadav, Santosh Timilsina, Kunal Baxi, Ratna Vadlamudi, Yidong Chen, Manjeet Rao

Publikováno v: Cancer Research. 83:3528-3528

Background: N6-methyladenosine (m6A) RNA methylation is a dynamic reversible epitranscriptomic modification that includes methyl transferases (writes m6A), demethylases (erases m6A) and reader proteins, which proofreads m6A marks of a specific site o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47b28f0b66b30d56d329d9204d0d29c6
https://doi.org/10.1158/1538-7445.am2023-3528