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Publikováno v:
Aquatic Toxicology. 64:407-418
We have investigated the regio- and stereoselective metabolism of phenanthrene by the liver microsomes of brown bullhead (Ameriurus nebulosus), a bottom dwelling fish species. The liver microsomes from untreated and 3-methylcholanthrene (3-MC)-treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c0f84e24412c9ddc124e07c9ba7c84
https://doi.org/10.1016/s0166-445x(03)00075-4
https://doi.org/10.1016/s0166-445x(03)00075-4
Autor:
H. L. Carrell, Joseph H. Saugier, Mahesh K. Lakshman, $ Won-Mohaiza Dashwood, Jenny P. Glusker, Herman J. C. Yeh, William M. Baird, Carol E. Afshar, and Gary Kenniston, Amy K. Katz, Surendrakumar Chaturvedi, Panna L. Kole
Publikováno v:
Journal of the American Chemical Society. 122:12629-12636
1,4-Dimethylbenzo[c]phenanthrene (1,4-DMBcPh) is the dimethylated analogue of the benzo[c]phenanthrene (BcPh), where one of its two methyl groups resides in the highly congested fjord-region. A comparative X-ray crystallographic analysis, described h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05913f0b8de3b095c3e2746b0d8373b3
https://doi.org/10.1021/ja002072w
https://doi.org/10.1021/ja002072w
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:551-553
Keywords: polycyclic aromatic hydrocarbons; PAHs; pyrene; benzo[a]pyrene; metabolites; dihydrodiols; diol epoxides; tetrols; carbon-13; synthesis; mass labeling; stable isotope labeling; carcinogenesis; mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02a509484cddc1f1fc74de8b9e7e36b9
https://doi.org/10.1002/jlcr.1267
https://doi.org/10.1002/jlcr.1267
Autor:
Mahesh K. Lakshman, Panna L. Kole, Mark B. Myers, Surendrakumar Chaturvedi, Michael A. Brown, James H. Windels
Publikováno v:
Tetrahedron: Asymmetry. 8:3375-3378
Diastereomeric formaldehyde acetals, formed from the reaction of racemic benzo[a]pyrene dihydrodiol and (−)-chloromethylmenthyl ether, are novel intermediates for effecting the convenient resolution of these metabolites by HPLC. This resolution tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c0d1844ff808124327bc295b3c49089
https://doi.org/10.1016/s0957-4166(97)00464-3
https://doi.org/10.1016/s0957-4166(97)00464-3
Publikováno v:
Marine Environmental Research. 39:51-55
The metabolism of benzo(a)pyrene (BaP), chrysene and phenanthrene by liver microsomes of brown bullhead (Ictalurus nebulosus) was investigated. Among the three PAHs, BaP was metabolized at the highest rate, chrysene at an intermediate rate and phenan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f02112fb43f8b76ecf7541adfecae09
https://doi.org/10.1016/0141-1136(94)00063-u
https://doi.org/10.1016/0141-1136(94)00063-u
Publikováno v:
Carcinogenesis. 16:525-530
The carcinogen dibenz[a,h]acridine (DB[a,h]ACR is metabolized predominantly to trans-3,4-dihydroxy-3,4-dihydro-dibenz[a,h]acridine (DB[a,h]ACR-3,4-diol) and the proximate carcinogen trans-10,11-dihydroxy-10,11-dihydrodibenz[a,h]acridine (DB[a,h]ACR-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0367f2d0eeeefa6969c7b6990b624f6b
https://doi.org/10.1093/carcin/16.3.525
https://doi.org/10.1093/carcin/16.3.525
Publikováno v:
Polycyclic Aromatic Compounds. 6:185-190
Bay-region diol epoxides are assumed to be ultimate metabolites responsible for the mutagenic and carcinogenic actions of polycyclic aromatic hydrocarbons (PAH). They exhibit enhanced activity when they are in a more sterically hindered environment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::668737e9d6aac8bd55c25d71ffb9a21d
https://doi.org/10.1080/10406639408031183
https://doi.org/10.1080/10406639408031183
Autor:
A. W. Wood, Richard L. Chang, Panna L. Kole, Subodh Kumar, S. K. Balani, Allan H. Conney, Ching-Quo Wong, S. Battista, Harish C. Sikka, Donald M. Jerina
Publikováno v:
Carcinogenesis. 14:2233-2237
The mutagenic activities of the enantiomers of the diastereomeric pair of bay-region 10,11-diol-8,9-epoxides of dibenz[a,h]acridine (DB[a,h]ACR) were evaluated in histidine-dependent strains of Salmonella typhimurium and in cultured Chinese hamster V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76739822ed84448b4874f30c55bdd843
https://doi.org/10.1093/carcin/14.11.2233
https://doi.org/10.1093/carcin/14.11.2233
Autor:
Panna L. Kole, Subodh Kumar
Publikováno v:
ChemInform. 22
A chemical synthesis of the phenolic ester of the triol epoxide derivatives of carcinogenic benzo[a]pyrene is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8724d6556c871789eaf847e8db79e101
https://doi.org/10.1002/chin.199124129
https://doi.org/10.1002/chin.199124129