Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pankuri Goraksha-Hicks"'
Autor:
Jeffrey C. Rathmell, Stephen N. Jones, Hugh Gannon, Jonathan L. Coloff, Pankuri Goraksha-Hicks, Yuxing Zhao, Emily F. Mason
Unlike the growth factor dependence of normal cells, cancer cells can maintain growth factor–independent glycolysis and survival through expression of oncogenic kinases, such as BCR-Abl. Although targeted kinase inhibition can promote cancer cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0265971764bdc7a6bc8155bddb0d138b
https://doi.org/10.1158/0008-5472.c.6500691
https://doi.org/10.1158/0008-5472.c.6500691
Autor:
Jeffrey C. Rathmell, Stephen N. Jones, Hugh Gannon, Jonathan L. Coloff, Pankuri Goraksha-Hicks, Yuxing Zhao, Emily F. Mason
Supplementary Figure Legends 1-9 from Aerobic Glycolysis Suppresses p53 Activity to Provide Selective Protection from Apoptosis upon Loss of Growth Signals or Inhibition of BCR-Abl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a890a7b339eee1146f7009bb7245f7
https://doi.org/10.1158/0008-5472.22383876.v1
https://doi.org/10.1158/0008-5472.22383876.v1
Autor:
W. Kimryn Rathmell, Jason W. Locasale, Andrew N. Macintyre, Allen Eng Juh Yeoh, Marc O. Warmoes, Tingyu Liu, Kristy L. Richards, E. Dale Abel, Amanda G. Nichols, Rigel J. Kishton, Aguirre A. de Cubas, Sivan Cohen, Timothy R. Gershon, Carson E. Barnes, Valerie A. Gerriets, Jeffrey C. Rathmell, Pankuri Goraksha-Hicks, Peter J. Siska
Publikováno v:
Cell Metabolism. 23:649-662
Summary T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic glycolysis to support proliferation, it is unclear to what e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98ecba0d43e099a2482c3b7db36b86f
https://doi.org/10.1016/j.cmet.2016.03.008
https://doi.org/10.1016/j.cmet.2016.03.008
Autor:
Annie L. Hsieh, Pankuri Goraksha-Hicks, Sharon J. Diskin, Zachary E. Stine, Chi V. Dang, Dean W. Felsher, Brian J. Altman, Jeffrey C. Rathmell, John B. Hogenesch, Mitchell A. Lazar, Zandra E. Walton, David I. Bellovin, M. Celeste Simon, Saikumari Y. Krishnanaiah, Arjun Sengupta, Aalim M. Weljie, Anand Venkataraman, John M. Maris, Arvin M. Gouw, Bo Li
Publikováno v:
Cell Metabolism. 22:1009-1019
SummaryThe MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding sites of the heterodimeric CLOCK-BMAL1 master circadian transcription factor. Hence,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9970685f00e5b22ed9b692d92d099db8
https://doi.org/10.1016/j.cmet.2015.09.003
https://doi.org/10.1016/j.cmet.2015.09.003
Autor:
Melissa A. Troester, Amy R. Johnson, Erin L. Kirk, Liza Makowski, Andrew N. Macintyre, Pankuri Goraksha-Hicks, Alex J. Freemerman, J. Justin Milner, Gina N. Sacks, Jeffery C. Rathmell
Publikováno v:
Journal of Biological Chemistry. 289:7884-7896
Glucose is a critical component in the proinflammatory response of macrophages (MΦs). However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating subsequent glucose metabolism in the inflammatory response are not well und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3419e7e078369aadf927e895ff762c97
https://doi.org/10.1074/jbc.m113.522037
https://doi.org/10.1074/jbc.m113.522037
Autor:
Rachel L. Schiesher, Pankuri Goraksha-Hicks, Ken Inoki, Hai-Xin Yuan, Eunjung Kim, Kun-Liang Guan, Thomas P. Neufeld, Li Li
Publikováno v:
Journal of Biological Chemistry. 285:19705-19709
The mammalian target of rapamycin (mTOR) is a key cell growth regulator, which forms two distinct functional complexes (mTORC1 and mTORC2). mTORC1, which is directly inhibited by rapamycin, promotes cell growth by stimulating protein synthesis and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0810e0711da6667262248d2b2ad1e62f
https://doi.org/10.1074/jbc.c110.102483
https://doi.org/10.1074/jbc.c110.102483
Autor:
Alex J, Freemerman, Amy R, Johnson, Gina N, Sacks, J Justin, Milner, Erin L, Kirk, Melissa A, Troester, Andrew N, Macintyre, Pankuri, Goraksha-Hicks, Jeffery C, Rathmell, Liza, Makowski
Publikováno v:
The Journal of biological chemistry. 289(11)
Glucose is a critical component in the proinflammatory response of macrophages (MΦs). However, the contribution of glucose transporters (GLUTs) and the mechanisms regulating subsequent glucose metabolism in the inflammatory response are not well und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd16672f532a7f3ae404df73cfe49be9
https://pubmed.ncbi.nlm.nih.gov/24492615
https://pubmed.ncbi.nlm.nih.gov/24492615
Autor:
Pankuri Goraksha-Hicks, Gábor Juhász, Thomas P. Neufeld, Yu Yun Chang, Daniel R. Mallin, Andrew M. Arsham, Laura K. Muller
Publikováno v:
Biochemical Society transactions. 37(Pt 1)
In response to nutrient deficiency, eukaryotic cells activate macroautophagy, a degradative process in which proteins, organelles and cytoplasm are engulfed within unique vesicles called autophagosomes. Fusion of these vesicles with the endolysosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cec56958266cb8587c87d29a13d452
https://pubmed.ncbi.nlm.nih.gov/19143638
https://pubmed.ncbi.nlm.nih.gov/19143638
Publikováno v:
Nature cell biology
TORC1 (Target of rapamycin complex 1) has a critical role in the regulation of cell growth and cell size. A wide range of signals, including amino acids, is known to activate TORC1. Here, we report the identification of Rag GTPases as novel activator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4c0deb08cd5dccba409649e7244c9e
https://pubmed.ncbi.nlm.nih.gov/18670446
https://pubmed.ncbi.nlm.nih.gov/18670446
Autor:
M. Celeste Simon, Annie Hsieh, Jeffrey C. Rathmell, Zach Stine, Anand Venkataraman, Brian J. Altman, Mitch Lazar, Pankuri Goraksha-Hicks, Chi Dang, John M. Maris, David I. Bellovin, John B. Hogenesch, Dean W. Felsher, Sharon J. Diskin, Arvin M. Gouw, Bo Li
Publikováno v:
Neuro-Oncology. 16:v214-v214
Cancer cells are known to have a metabolic advantage, but it is not known whether the circadian clock, which couples metabolic and cell cycles, restrains cancer cell metabolism and growth. We report that the deregulated expression of the MYC or MYCN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af268c32f9744327e3b1c3f388d3fc60
https://doi.org/10.1093/neuonc/nou278.6
https://doi.org/10.1093/neuonc/nou278.6