Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Pankaj Seth"'
Publikováno v:
IBRO Neuroscience Reports, Vol 17, Iss , Pp 73-82 (2024)
Neuroblastomas are pediatric tumors arising from undifferentiated cells of neural crest origin with stem cell-like characteristics. Dysregulation of Wnt/β-catenin signaling has been shown to be linked to the development of various tumors. Activated
Externí odkaz:
https://doaj.org/article/306a87f63d1a4d5cb607bb23c9bc73ea
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Neurotropic viruses can cross the otherwise dynamically regulated blood-brain barrier (BBB) and affect the brain cells. Zika virus (ZIKV) is an enveloped neurotropic Flavivirus known to cause severe neurological complications, such as encephalitis an
Externí odkaz:
https://doaj.org/article/1ee4fec335524d618de4cb10f9fa4fc0
Autor:
Priyanka, Pankaj Seth
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Mortalin is a chaperone protein that regulates physiological functions of cells. Its multifactorial role allows cells to survive pathological conditions. Pharmacological, chemical, and siRNA-mediated downregulation of mortalin increases oxidative str
Externí odkaz:
https://doaj.org/article/5a5457cebc0a462694a3e5136eaecdb7
Autor:
Ibrahim Olabayode Saliu, Reshma Bhagat, Olubukola Benedicta Ojo, Afolabi C. Akinmoladun, M. Tolulope Olaleye, Pankaj Seth, Velayudhan Rema
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 264-276 (2021)
Oxidative stress and excitotoxicity are some of the pathophysiological abnormalities in hypoxia-induced brain injury. This study evaluated the intrinsic antioxidant property of methanol fruit extract of Tetrapleura tetraptera (TT), traditionally used
Externí odkaz:
https://doaj.org/article/05064f2eeb244882b2f43d920a8701b7
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-20 (2020)
Abstract Background In human immunodeficiency virus-1 (HIV-1) infection, activation of astrocytes induces imbalance in physiological functions due to perturbed astrocytic functions that unleashes toxicity on neurons. This leads to inflammatory respon
Externí odkaz:
https://doaj.org/article/2972421cdc604e09a594059f55e6d51d
Autor:
Deepali Singh, Apurva Agrawal, Chitra Mohinder Singh Singal, Hriday Shanker Pandey, Pankaj Seth, Shiv Kumar Sharma
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-10 (2020)
Abstract Amyloid beta is a major constituent of the plaques found in the brains of patients suffering from Alzheimer’s disease (AD). A growing body of research work suggests that neuroinflammation plays important roles in the development of AD. Thu
Externí odkaz:
https://doaj.org/article/496ddff650884c54b8f27b33a2af3062
Publikováno v:
ASN Neuro, Vol 13 (2021)
Glial cells perform important supporting functions for neurons through a dynamic crosstalk. Neuron–glia communication is the major phenomenon to sustain homeostatic functioning of the brain. Several interactive pathways between neurons and astrocyt
Externí odkaz:
https://doaj.org/article/bfa5ffad0c674a4f9e2f552586d57968
Publikováno v:
eLife, Vol 10 (2021)
Cellular metabolism has key roles in T cells differentiation and function. CD4+ T helper-1 (Th1), Th2, and Th17 subsets are highly glycolytic while regulatory T cells (Tregs) use glucose during expansion but rely on fatty acid oxidation for function.
Externí odkaz:
https://doaj.org/article/851c6bd2a26549a4b642403b49029a4d
Autor:
Md Imam Faizan, Rituparna Chaudhuri, Shakti Sagar, Sarah Albogami, Nisha Chaudhary, Iqbal Azmi, Areej Akhtar, Syed Mansoor Ali, Rohit Kumar, Jawed Iqbal, Mohan C. Joshi, Gaurav Kharya, Pankaj Seth, Soumya Sinha Roy, Tanveer Ahmad
Publikováno v:
Cells, Vol 11, Iss 19, p 2969 (2022)
Circulating cell-free mitochondrial DNA (cf-mtDNA) has been found in the plasma of severely ill COVID-19 patients and is now known as a strong predictor of mortality. However, the underlying mechanism of mtDNA release is unexplored. Here, we show a n
Externí odkaz:
https://doaj.org/article/065ab8c2e2fe4aaba705f28a52a2db0a
Autor:
Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W.-M. Fan, Pankaj Seth
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108831- (2021)
Summary: Although T cell expansion depends on glycolysis, T effector cell differentiation requires signaling via the production of reactive oxygen species (ROS). Because the pentose phosphate pathway (PPP) regulates ROS by generating nicotinamide ade
Externí odkaz:
https://doaj.org/article/acce3d944b2e4a188f1edec534596d20