Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Pankaj P. Pasricha"'
Autor:
Lakshmikanth L. Chikkamenahalli, Erik Jessen, Cheryl E. Bernard, W.K. Eddie Ip, Margaret Breen-Lyles, Gianluca Cipriani, Suraj R. Pullapantula, Ying Li, Shefaa AlAsfoor, Laura Wilson, Kenneth L. Koch, Braden Kuo, Robert J. Shulman, Bruno P. Chumpitazi, Travis J. McKenzie, Todd A. Kellogg, James Tonascia, Frank A. Hamilton, Irene Sarosiek, Richard McCallum, Henry P. Parkman, Pankaj J. Pasricha, Thomas L. Abell, Gianrico Farrugia, Surendra Dasari, Madhusudan Grover
Publikováno v:
iScience, Vol 27, Iss 3, Pp 108991- (2024)
Summary: Gastrointestinal immune cells, particularly muscularis macrophages (MM) interact with the enteric nervous system and influence gastrointestinal motility. Here we determine the human gastric muscle immunome and its changes in patients with id
Externí odkaz:
https://doaj.org/article/6c7eae83970a49d480513cd5b3e3ac36
Autor:
Subhash Kulkarni, Monalee Saha, Jared Slosberg, Alpana Singh, Sushma Nagaraj, Laren Becker, Chengxiu Zhang, Alicia Bukowski, Zhuolun Wang, Guosheng Liu, Jenna M Leser, Mithra Kumar, Shriya Bakhshi, Matthew J Anderson, Mark Lewandoski, Elizabeth Vincent, Loyal A Goff, Pankaj Jay Pasricha
Publikováno v:
eLife, Vol 12 (2023)
The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cells migratin
Externí odkaz:
https://doaj.org/article/d74ff71d09fa45de82dc220b51c19e93
Autor:
Jacqueline Koshorek, Yujie Wang, Daniela Pimentel Maldonado, Maria I. Reyes-Mantilla, Danielle Obando, Alexandra Balshi, Michael Comisac, Pankaj Jay Pasricha, Scott D. Newsome
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionThe effect of stiff person syndrome spectrum disorders (SPSD) on the gastrointestinal tract (GIT) is unknown. This case series aims to characterize the prevalence and types of GI dysfunction in individuals with SPSD.MethodsA retrospective
Externí odkaz:
https://doaj.org/article/e4d244e5f9604eb897391f74a2424749
Autor:
Hannah Ceuleers, Nikita Hanning, Michelle De bruyn, Joris G De Man, Heiko U De Schepper, Qian Li, Liansheng Liu, Steven Abrams, Annemieke Smet, Jurgen Joossens, Koen Augustyns, Ingrid De Meester, Pankaj J Pasricha, Benedicte Y De Winter
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic a
Externí odkaz:
https://doaj.org/article/2e982d8ea77b4cd0af0421bfcbe928ff
Publikováno v:
Physiological Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)
Abstract We sought to quantify the characteristics of acid reflux episodes in patients with extraesophageal GERD symptoms (EES), hiatal hernia (HH), and erosive esophagitis (EroE) using multichannel intraluminal impedance pH (MII‐pH) and investigat
Externí odkaz:
https://doaj.org/article/c477273d241f48dfa3d7a92214bb09db
Autor:
Chia-Ning Shen, King-Siang Goh, Chi-Ruei Huang, Tsai-Chen Chiang, Chih-Yuan Lee, Yung-Ming Jeng, Shih-Jung Peng, Hung-Jen Chien, Mei-Hsin Chung, Ya-Hsien Chou, Chi-Che Hsieh, Subhash Kulkarni, Pankaj J. Pasricha, Yu-Wen Tien, Shiue-Cheng Tang
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 98-113 (2019)
Background: The lymphatic system is involved in metastasis in pancreatic cancer progression. In cancer staging, lymphatic spread has been used to assess the invasiveness of tumor cells. However, from the endothelium's perspective, the analysis downpl
Externí odkaz:
https://doaj.org/article/db0c423ebc8c4514b119ea5db17a48de
Autor:
Zachary A. Cordner, Qian Li, Liansheng Liu, Kellie L. Tamashiro, Aditi Bhargava, Timothy H. Moran, Pankaj Jay Pasricha
Publikováno v:
JCI Insight, Vol 6, Iss 6 (2021)
Functional dyspepsia (FD) is associated with chronic gastrointestinal distress and with anxiety and depression. Here, we hypothesized that aberrant gastric signals, transmitted by the vagus nerve, may alter key brain regions modulating affective and
Externí odkaz:
https://doaj.org/article/2bb533609db54284a9326d14464a2427
Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis
Autor:
Madhusudan Grover, Simon J. Gibbons, Asha A. Nair, Cheryl E. Bernard, Adeel S. Zubair, Seth T. Eisenman, Laura A. Wilson, Laura Miriel, Pankaj J. Pasricha, Henry P. Parkman, Irene Sarosiek, Richard W. McCallum, Kenneth L. Koch, Thomas L. Abell, William J. Snape, Braden Kuo, Robert J. Shulman, Travis J. McKenzie, Todd A. Kellogg, Michael L. Kendrick, James Tonascia, Frank A. Hamilton, Gianrico Farrugia, the NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Background Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear. Methods Diabetic g
Externí odkaz:
https://doaj.org/article/20e8bd3f92e147689f45774f66978f5d
Autor:
Payal Joglekar, Hua Ding, Pablo Canales-Herrerias, Pankaj Jay Pasricha, Justin L. Sonnenburg, Daniel A. Peterson
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Gut-derived immunoglobulin A (IgA) is the most abundant antibody secreted in the gut that shapes gut microbiota composition and functionality. However, most of the microbial antigens targeted by gut IgA remain unknown, and the functional eff
Externí odkaz:
https://doaj.org/article/bd8e93cbce1f4eb3ba499b83fc751a32
Autor:
Elias S. Siraj, Carol Homko, Laura A. Wilson, Patrick May, Ajay D. Rao, Jorge Calles, Gianrico Farrugia, William L. Hasler, Kenneth L. Koch, Linda Nguyen, William J. Snape, Thomas L. Abell, Irene Sarosiek, Richard W. McCallum, Pankaj J. Pasricha, John Clarke, James Tonascia, Frank Hamilton, Henry P. Parkman
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
IntroductionIndividuals with diabetes are at increased risk for complications, including gastroparesis. Type 1 diabetes mellitus (T1DM) is an autoimmune disorder resulting in decreased beta-cell function. Glutamic acid decarboxylase-65 antibody (GADA
Externí odkaz:
https://doaj.org/article/6bed0f1115444ce1833356b4ae4df286