Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Panjamurthy Kuppusamy"'
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of cancer treatment that significantly impacts patients' quality of life. This study investigated the effects of targeting metabolic pathways on bortezomib-in
Externí odkaz:
https://doaj.org/article/6707336280f14c9281bfb41ab2bf9e6a
Autor:
Arumugam Nagalingam, Sumit Siddharth, Sheetal Parida, Nethaji Muniraj, Dimiter Avtanski, Panjamurthy Kuppusamy, Justin Elsey, Jack L. Arbiser, Balázs Győrffy, Dipali Sharma
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Obese women with hormone receptor-positive breast cancer exhibit poor response to therapy and inferior outcomes. However, the underlying molecular mechanisms by which obesity/hyperleptinemia may reduce the efficacy of hormonal therapy remain
Externí odkaz:
https://doaj.org/article/77145f81cf624b838a35440b7673401f
Autor:
Sumit Siddharth, Panjamurthy Kuppusamy, Qitong Wu, Arumugam Nagalingam, Neeraj K. Saxena, Dipali Sharma
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8083 (2022)
Hepatocellular carcinoma (HCC) incidence, as well as related mortality, has been steadily increasing in the USA and across the globe, partly due to the lack of effective therapeutic options for advanced HCC. Though sorafenib is considered standard-of
Externí odkaz:
https://doaj.org/article/5f9a4923de644b8d94321cc2b401605e
Autor:
Neeraj K. Saxena, Dipali Sharma, Shivendra V. Singh, Panjamurthy Kuppusamy, Arumugam Nagalingam
PDF file - 141KB, Supplemental Figure 6 ERK and RSK activation is important for WFA-mediated inhibition of clonogenicity of breast cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6892f93adf129704419d8e07db61f9cb
https://doi.org/10.1158/0008-5472.22401933.v1
https://doi.org/10.1158/0008-5472.22401933.v1
Autor:
Neeraj K. Saxena, Dipali Sharma, Shivendra V. Singh, Panjamurthy Kuppusamy, Arumugam Nagalingam
PDF file - 103KB, Supplementary Figure 10 Withaferin A induces recruitment of CHOP, pElk1 and release of HDAC1 from DR5 promoter.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1177052aeba53bc39cefcd41aed54f66
https://doi.org/10.1158/0008-5472.22401951.v1
https://doi.org/10.1158/0008-5472.22401951.v1
Autor:
Neeraj K. Saxena, Dipali Sharma, Shivendra V. Singh, Panjamurthy Kuppusamy, Arumugam Nagalingam
Withaferin A (WFA) is a steroidal lactone with antitumor effects manifested at multiple levels that are mechanistically obscure. Using a phospho-kinase screening array, we discovered that WFA activated phosphorylation of the S6 kinase RSK (ribosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e42aa7d8c3a92cb39df8991d7013132f
https://doi.org/10.1158/0008-5472.c.6505950
https://doi.org/10.1158/0008-5472.c.6505950
Autor:
Neeraj K. Saxena, Dipali Sharma, Shivendra V. Singh, Panjamurthy Kuppusamy, Arumugam Nagalingam
PDF file - 99KB, Supplementary Figure 8 CHOP is important for Withaferin A mediated inhibition of breast cancer cell growth.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656208b5442866f0050a307ef35301ea
https://doi.org/10.1158/0008-5472.22401927
https://doi.org/10.1158/0008-5472.22401927
Autor:
Neeraj K. Saxena, Dipali Sharma, Shivendra V. Singh, Panjamurthy Kuppusamy, Arumugam Nagalingam
PDF file - 147KB, Supplemental Figure 4 WFA activates RSK in an ERK-dependent manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6844427e0bccfe22889bfeb94823e89a
https://doi.org/10.1158/0008-5472.22401939
https://doi.org/10.1158/0008-5472.22401939
Autor:
Neeraj K. Saxena, Dipali Sharma, Shivendra V. Singh, Panjamurthy Kuppusamy, Arumugam Nagalingam
PDF file - 115KB, Supplemental Figure 3 WFA increases phosphorylation of ERK and RSK.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eee00cee870485d2f40bd6122e69e7a
https://doi.org/10.1158/0008-5472.22401942
https://doi.org/10.1158/0008-5472.22401942