Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Panja Strickner"'
Autor:
François Lehembre, Benedicte Haenig, Elise Simon, Daniela Sabato, Julie Erupathil, Matthias Gstaiger, Imke Renz, Lhéanna Klaeylé, Meenhard Herlyn, Patricia Brafford, Richard W. D. Welford, Min Xiao, Panja Strickner, Alexander Schäfer, Clemens Krepler
Publikováno v:
Oncogene. 40(9)
The clinical benefit of MAPK pathway inhibition in melanoma patients carrying BRAF mutations is temporal. After the initial response to treatment, the majority of tumors will develop resistance and patients will relapse. Here we demonstrate that the
Autor:
Lars Prade, Panja Strickner, Corinna Grisostomi, Beat Steiner, Walter Fischli, Alexander Treiber, Daniel Bur, Olivier Bezencon, Ľuboš Remeň, Patrick Hess, Sylvia Richard-Bildstein, Olivier Corminboeuf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6291-6296
The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibit
Autor:
Corinna Grisostomi, Beat Steiner, Walter Fischli, Patrick Hess, Sylvia Richard-Bildstein, Olivier Corminboeuf, Panja Strickner, Lars Prade, Olivier Bezencon, Lubos Remen, Alexander Treiber, Daniel Bur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6286-6290
The discovery of a new series of piperidine-based renin inhibitors is described herein. SAR optimization upon the P3 renin sub-pocket is described, leading to the discovery of 9 and 41, two bioavailable renin inhibitors orally active at low doses in
Autor:
Christoph Binkert, Panja Strickner, Thierry Sifferlen, Walter Fischli, Stephane Delahaye, Sylvia Richard-Bildstein, Olivier Corminboeuf, Olivier Bezencon, Daniel Bur, Lubos Remen, Alexander Treiber, Corinna Grisostomi, Thomas Weller, Christoph Boss, Beat Steiner, Lars Prade, Patrick Hess
Publikováno v:
Journal of medicinal chemistry. 52(12)
Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally designed and prepared. Optimization of the positions 3, 6, and 7 of the diazabicyclonene template led to potent renin inhibitors
Autor:
Elizabeth Cauchon, Jean-Pierre Falgueyret, Steve Rowland, Susana Liu, Panja Strickner, M. David Percival, Daigen Xu, Christoph Binkert
Publikováno v:
Analytical biochemistry. 388(1)
Plasma renin activity (PRA) is a well-established biomarker for assessing the efficacy of various antihypertensive agents such as direct renin inhibitors, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors (ACEIs). PRA measur
Autor:
Olivier Bezençon, Daniel Bur, Thomas Weller, Sylvia Richard-Bildstein, Luboš Remeň, Thierry Sifferlen, Olivier Corminboeuf, Corinna Grisostomi, Christoph Boss, Lars Prade, Stéphane Delahaye, Alexander Treiber, Panja Strickner, Christoph Binkert, Patrick Hess, Beat Steiner, Walter Fischli
Publikováno v:
Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 12, p3689-3702, 14p
Autor:
François Lehembre, Panja Strickner, Sun Jin Kim, Junqin He, Seok Joong Yun, Jang Seong Kim, Urs Regenass, Emily C. Brantley, Seung Wook Kim, Isaiah J. Fidler, Dominic Fan
Publikováno v:
Translational Oncology. (1):39-47
Endothelin receptors (ETRs) are often overexpressed in ovarian tumors, which can be resistant to conventional therapies. Thus, we investigated whether blockage of the ETR pathways using the dual ETR antagonist macitentan combined with taxol or cispla