PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice.

Autor: Vilella A; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy. Electronic address: antonietta.vilella@unimore.it., Bodria M; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy., Papotti B; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Zanotti I; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Zimetti F; Department of Food and Drug, University of Parma, 43124 Parma, Italy. Electronic address: francesca.zimetti@unipr.it., Remaggi G; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Elviri L; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Potì F; Department of Medicine and Surgery, Unit of Neurosciences, University of Parma, 43121, Parma, Italy., Ferri N; Department of Medicine, University of Padova, 35129, Padova, Italy; Veneto Institute of Molecular Medicine (VIMM), 35129, Padova, Italy., Lupo MG; Department of Medicine, University of Padova, 35129, Padova, Italy., Panighel G; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Daini E; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy., Vandini E; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Zoli M; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy., Giuliani D; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy., Bernini F; Department of Food and Drug, University of Parma, 43124 Parma, Italy.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2024 Jan; Vol. 115, pp. 517-534. Date of Electronic Publication: 2023 Nov 13.

An innovative berberine formulation is able to improve bbr bioavailability and the lipid and glycemic profile in HFD-fed mice

Autor: Lupo, M.G., Panighel, G., Ferrarese, I., Brilli, E., Tarantino, G., Dall'Acqua, S., Ferri, N.

Publikováno v: In Atherosclerosis August 2022 355

PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer's Disease.

Autor: Papotti B; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Adorni MP; Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy., Marchi C; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Zimetti F; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Ronda N; Department of Food and Drug, University of Parma, 43124 Parma, Italy., Panighel G; Department of Medicine, University of Padova, 35131 Padova, Italy., Lupo MG; Department of Medicine, University of Padova, 35131 Padova, Italy., Vilella A; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy., Giuliani D; Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy., Ferri N; Department of Medicine, University of Padova, 35131 Padova, Italy., Bernini F; Department of Food and Drug, University of Parma, 43124 Parma, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Oct 13; Vol. 23 (20). Date of Electronic Publication: 2022 Oct 13.

Investigating the in vitro mode of action of okra ( Abelmoschus esculentus ) as hypocholesterolemic, anti-inflammatory, and antioxidant food.

Autor: Panighel G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Ferrarese I; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Lupo MG; Department of Medicine, Via Giustiniani 2, 35128 Padova, Italy., Sut S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Ferri N; Department of Medicine, Via Giustiniani 2, 35128 Padova, Italy.

Publikováno v: Food chemistry. Molecular sciences [Food Chem (Oxf)] 2022 Jul 25; Vol. 5, pp. 100126. Date of Electronic Publication: 2022 Jul 25 (Print Publication: 2022).

Evaluation of the effects of natural isoquinoline alkaloids on low density lipoprotein receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) in hepatocytes, as new potential hypocholesterolemic agents.

Autor: Maharjan B; Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu 44613, Nepal; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan., Payne DT; International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), Namiki 1-1, Tsukuba, Ibaraki, 305-0044, Japan., Ferrarese I; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Giovanna Lupo M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Kumar Shrestha L; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan., Hill JP; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan., Ariga K; International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Ibaraki 305-0044, Japan; Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan., Rossi I; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Sharan Shrestha S; Department of Botany, Tribhuvan University, Kathmandu 44613, Nepal., Panighel G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Lal Swagat Shrestha R; Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu 44613, Nepal. Electronic address: swagatstha@gmail.com., Sut S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy., Ferri N; Department of Medicine, of Padova, Via Giustiniani 2, 35100 Padova, Italy., Dall'Acqua S; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35121 Padova, Italy. Electronic address: stefano.dallacqua@unipd.it.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2022 Apr; Vol. 121, pp. 105686. Date of Electronic Publication: 2022 Feb 16.