Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Panduka B. Koswatta"'
Autor:
Carl J. Lovely, Panduka B. Koswatta, Jayanta Das, Heather M. Lima, Sabha Kasiri, Nicole N. Khatibi, Arunoday Bhan, Subhrangsu S. Mandal, Muhammed Yousufuddin, Beatriz J. Garcia-Barboza
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:1608-1621
The total synthesis of a number of representative natural products isolated from Leucetta and Clathrina sponges containing a polysubstituted 2-aminoimidazole are described. These syntheses take advantage of the site specific metallation reactions of
Publikováno v:
European Journal of Organic Chemistry. 2015:2603-2613
An exploration of an abiotic approach to spirocalcaridines A and B is described centered on electrophile-induced dearomatizing spirocyclization of aryl enyne derivatives. Elaboration of the α-iodoenone via an Ullmann-like, copper-catalyzed amidation
Autor:
Daniel W. Armstrong, Carl J. Lovely, Panduka B. Koswatta, Zachary S. Breitbach, Qing Feng, Edra Dodbiba
Publikováno v:
Supramolecular Chemistry. 22:758-767
The enantiomeric separation of a series of fifteen racemic 4,5-disubstituted imidazole compounds was examined by high performance liquid chromatography (HPLC) and capillary electrophoresis (CE). These alkaloid analytes are important precursors for th
Publikováno v:
Tetrahedron Letters. 59:2306
Publikováno v:
Synthesis. 2009:2970-2982
A biomimetically guided total synthesis of the Leucetta-derived aminoimidazole alkaloid, calcaridine A, is described. The synthesis relies on position selective metalations of a 4,5-diiodo-imidazole derivative to provide a tetrasubstituted imidazole.
Publikováno v:
Organic Letters. 10:5055-5058
The first total synthesis of the Leucetta alkaloid calcaridine A is described based on a biosynthetic postulate. Application of an oxidative rearrangement of a 4,5-disubstituted imidazole leads to the formation of both calcaridine A and epi-calcaridi
Autor:
Carl J. Lovely, Panduka B. Koswatta
Publikováno v:
Tetrahedron Letters. 51:164-166
Simple total syntheses of two Leucetta -derived marine alkaloids have been developed using position-specific halogen-metal exchange of polyhaloimidazoles to introduce the benzyl substituted sidechains. Introduction of the C2 amine group by lithiation
Autor:
Carl J. Lovely, Panduka B. Koswatta
Publikováno v:
Tetrahedron Letters. 50:4998-5000
A short and operationally simple total synthesis of two Leucetta -derived marine alkaloids has been developed, which rely on position specific halogen–metal exchange to introduce the benzyl-substituted side chain. Introduction of the C2 amine group
Short total syntheses of the Leucetta-derived alkaloids, kealiinines A-C, have been accomplished using an intramolecular Friedel-Crafts-dehydration sequence of a bis benzylic diol. The precursor diol was obtained through a series of position-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5b88f235ac6ae09aef0153bbb1783a
https://europepmc.org/articles/PMC3876472/
https://europepmc.org/articles/PMC3876472/
Autor:
Carl J. Lovely, Panduka B. Koswatta
Publikováno v:
ChemInform. 42
Marine sponges belonging to the Calcarea family have been studied for some time and have yielded a wide variety of structurally unique secondary metabolites. In particular, these sponges have produced a large number of bioactive alkaloids containing