Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function.

Autor: Mulley JF; School of Biological Sciences, Bangor University, Brambell Building, Deiniol Road, Bangor, Gwynedd LL57 2UW, United Kingdom. j.mulley@bangor.ac.uk., Hargreaves AD, Hegarty MJ, Heller RS, Swain MT

Publikováno v: BMC genomics [BMC Genomics] 2014 Dec 06; Vol. 15, pp. 1074. Date of Electronic Publication: 2014 Dec 06.

The effects of natural ligands of hormone receptors and their antagonists on telomerase activity in the androgen sensitive prostatic cancer cell line LNCaP.

Autor: Bouchal J; Laboratory of Molecular Pathology, CMBM and Institute of Pathology, Faculty of Medicine, Palacký University, Olomouc, Czech Republic., Kolár Z, Mad'arová J, Hlobilková A, von Angerer E

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2002 Mar 15; Vol. 63 (6), pp. 1177-81.

Development of Cagrilintide, a Long-Acting Amylin Analogue

Autor: Kirsten Raun, Eva Johansson, Morten Schlein, Ulrich Sensfuss, Christian Poulsen, Simone Fulle, Kirsten Dahl, Lauge Schäffer, Ann Maria Kruse Hansen, Trine R. Clausen, Jakob Lerche Hansen, Charlotta Dornonville de la Cour, Rikke Bjerring Skyggebjerg, Thomas Kruse, Claus Bekker Jeppesen

Publikováno v: Journal of Medicinal Chemistry. 64:11183-11194

A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort. The amylin analogue pramlintide is commercially available for diabetes treatment as an adjunc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaa793c2245d270ddc8b3148f54058f
https://doi.org/10.1021/acs.jmedchem.1c00565

Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study

Autor: Emma Rose McGlone, Tricia Tan, Nicolai J. Wewer Albrechtsen, Jens J. Holst, Joyceline Cuenco, Julian R.F. Walters, Charlotte Ling, Bernard Khoo, Stephen R. Bloom, Khalefah Malallah, Ahmed R. Ahmed, Omar A. Khan, Royce P Vincent, Surabhi Verma

Publikováno v: McGlone, E R, Malallah, K, Cuenco, J, Wewer Albrechtsen, N J, Holst, J J, Vincent, R P, Ling, C, Khan, O A, Verma, S, Ahmed, A R, Walters, J R F, Khoo, B, Bloom, S R & Tan, T M M 2021, ' Differential effects of bile acids on the postprandial secretion of gut hormones : A randomized crossover study ', American Journal of Physiology-Endocrinology and Metabolism, vol. 320, no. 4, pp. E671-E679 . https://doi.org/10.1152/AJPENDO.00580.2020

Bile acids (BA) regulate postprandial metabolism directly and indirectly by affecting the secretion of gut hormones like glucagon-like peptide-1 (GLP-1). The postprandial effects of BA on the secretion of other metabolically active hormones are not w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd50f1e4356fed4e14596c5c3feb212
https://doi.org/10.1152/ajpendo.00580.2020

Effects of long-term consumption of sucralose associated with high-fat diet in male mice

Autor: Alessandra Gambero, Paola Sousa Santos, Cintia Rabelo Paiva Caria, Caio Cesar Ruy

Publikováno v: Food & Function. 12:9904-9911

Sucralose is a widely consumed non-nutritive sweetener (NNS). Studies have shown that some NNS can favor weight gain by altering the intestinal microbiota, satiety hormone production, or aspects related to glucose homeostasis. In this study, we inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7037a47b3a0debc8cfbaa224c17614b4
https://doi.org/10.1039/d1fo02135d