Zobrazeno 1 - 10
of 1 642
pro vyhledávání: '"Pancreatic β-cells"'
Autor:
Emmanuel Kokori, Gbolahan Olatunji, Ikponmwosa Jude Ogieuhi, John Ehi Aboje, Doyin Olatunji, Sikiru Ademola Aremu, Stephen Chukwuemeka Igwe, Abdulrahmon Moradeyo, Yusuf Ismaila Ajayi, Nicholas Aderinto
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract This review explores the immunomodulatory potential of Teplizumab and its impact on pancreatic β-cell function in T1D. Characterized by the autoimmune destruction of insulin-producing beta cells, T1D’s management involves maintaining glyc
Externí odkaz:
https://doaj.org/article/9115a43a5147473cbec01891fc6a9e78
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Glucocorticoids (GCs) are known to stimulate pancreatic beta (β)-cell apoptosis via several mechanisms, including oxidative stress. Our previous study suggested an increase in dexamethasone-induced pancreatic β-cell apoptosis via a reducti
Externí odkaz:
https://doaj.org/article/65d6afc4ecc1462aac3cc1992bb61a72
Autor:
Kukkala Kiran Kumar, Elhadi Husein Aburawi, Milos Ljubisavljevic, Melvin Khee Shing Leow, Xu Feng, Suraiya Anjum Ansari, Bright Starling Emerald
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-31 (2024)
Abstract Diabetes mellitus is a chronic disease that impairs metabolism, and its prevalence has reached an epidemic proportion globally. Most people affected are with type 2 diabetes mellitus (T2DM), which is caused by a decline in the numbers or fun
Externí odkaz:
https://doaj.org/article/0bc565514e6c413996838412b83b87a1
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 6, Pp 684-692 (2024)
ABSTRACT Aims The aim of this study was to better understand how the chemotherapy drug doxorubicin contributes to the development of β‐cell dysfunction and to explore its relationship with mitochondrial aldehyde dehydrogenase‐2 (ALDH2). Material
Externí odkaz:
https://doaj.org/article/19eb8ed8b1574309887ca802bf57cd69
Autor:
Patricia Marqués, Jesús Burillo, Carlos González-Blanco, Beatriz Jiménez, Gema García, Ana García-Aguilar, Sarai Iglesias-Fortes, Ángela Lockwood, Carlos Guillén
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Sirtuin1 (SIRT1) activity decreases the tuberous sclerosis complex 2 (TSC2) lysine acetylation status, inhibiting the mechanistic target of rapamycin complex 1 (mTORC1) signalling and concomitantly, activating autophagy. This study analyzes
Externí odkaz:
https://doaj.org/article/ddc91a7cd5c541739accb8de5719e07e
Autor:
Sofi Imtiyaz Ali, Ahmed M. E. Elkhalifa, Showkat Ul Nabi, Faisal Sualeh Hayyat, Mehak Nazar, Syed Taifa, Rabia Rakhshan, Iqra Hussain Shah, Muzaffer Shaheen, Imtiyaz Ahmad Wani, Umar Muzaffer, Ovais Shabir Shah, Dil Mohammad Makhdoomi, Elsadig Mohamed Ahmed, Khalil A. A. Khalil, Elsharif.A. Bazie, Khalid Ibrahim Zawbaee, Moataz Mohamed Al Hasan Ali, Rakan J. Alanazi, Ibrahim Ali Al Bataj, Saeed Musfar Al Gahtani, Ali Jubran Salwi, Lina Saeed Alrodan
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-21 (2024)
Abstract Background Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca2+ pathways have been identified as pot
Externí odkaz:
https://doaj.org/article/286ea967baa6472e9a24e93c47b586ad
Publikováno v:
Quality in Sport, Vol 19 (2024)
Introduction: Pompe disease is classified as a metabolic myopathy and is a glycogen storage disorder inherited in an autosomal recessive manner due to a mutation in the gene encoding the enzyme α-glucosidase. There are two main forms: infantile and
Externí odkaz:
https://doaj.org/article/8f06c4a74a434fcb8424e7572865038b
Autor:
Martin Jabůrek, Eduardo Klöppel, Pavla Průchová, Oleksandra Mozheitova, Jan Tauber, Hana Engstová, Petr Ježek
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103283- (2024)
We asked whether acute redox signaling from mitochondria exists concomitantly to fatty acid- (FA-) stimulated insulin secretion (FASIS) at low glucose by pancreatic β-cells. We show that FA β-oxidation produces superoxide/H2O2, providing: i) mitoch
Externí odkaz:
https://doaj.org/article/2c62519b300e44dfa58a44a1a60d3131
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 14, Iss 2, Pp 148-161 (2024)
Background and aim: The purpose of the study was to investigate the anti-hyperglycemic effect of extra virgin sacha inchi oil (EVSIO) and its possible mechanisms and actions against pancreatic β-cell death and dysfunction in type 2 diabetic (T2D) ra
Externí odkaz:
https://doaj.org/article/f31c88fec66f40659f4c2d0d9df133f5
Autor:
Radoslav Stojchevski, Sara Velichkovikj, Jane Bogdanov, Nikola Hadzi-Petrushev, Mitko Mladenov, Leonid Poretsky, Dimiter Avtanski
Publikováno v:
Data in Brief, Vol 57, Iss , Pp 110952- (2024)
This paper presents a dataset obtained from an RT2-qPCR array analysis of rat pancreatic RIN-m cells treated with two monocarbonyl analogs of curcumin (MACs), C66 and B2BrBC in the presence or absence of streptozotocin (STZ). The array quantified the
Externí odkaz:
https://doaj.org/article/a4be3db87d0e416ab86bd6a0c0e47547