Zobrazeno 1 - 10
of 438
pro vyhledávání: '"Pancreas/metabolism"'
Autor:
Ernesto Rodriguez, Kelly Boelaars, Kari Brown, Katarina Madunić, Thomas van Ee, Frederike Dijk, Joanne Verheij, R. J. Eveline Li, Sjoerd T. T. Schetters, Laura L. Meijer, Tessa Y. S. Le Large, Else Driehuis, Hans Clevers, Sven C. M. Bruijns, Tom O’Toole, Sandra J. van Vliet, Maarten F. Bijlsma, Manfred Wuhrer, Geert Kazemier, Elisa Giovannetti, Juan J. Garcia-Vallejo, Yvette van Kooyk
Publikováno v:
Rodriguez, E, Boelaars, K, Brown, K, Madunić, K, van Ee, T, Dijk, F, Verheij, J, Li, R J E, Schetters, S T T, Meijer, L L, le Large, T Y S, Driehuis, E, Clevers, H, Bruijns, S C M, O’Toole, T, van Vliet, S J, Bijlsma, M F, Wuhrer, M, Kazemier, G, Giovannetti, E, Garcia-Vallejo, J J & van Kooyk, Y 2022, ' Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits ', Communications Biology, vol. 5, no. 1, 41 . https://doi.org/10.1038/s42003-021-02934-0
Communications Biology, 5(1). NATURE PORTFOLIO
Communications Biology, 5(1):41. Springer Nature
Communications Biology, 5(1). Nature Research
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Communications Biology
Communications Biology, 5(1). NATURE PORTFOLIO
Communications Biology, 5(1):41. Springer Nature
Communications Biology, 5(1). Nature Research
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Communications Biology
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a 5-year survival rate of only 9%. Despite the fact that changes in glycosylation patterns during tumour progression have been reported, no systematic approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe60e99fc9fac54f16c9d2722be2dd7
https://research.vumc.nl/en/publications/17bbcc4c-7f8c-49d8-a630-a0261bf5c338
https://research.vumc.nl/en/publications/17bbcc4c-7f8c-49d8-a630-a0261bf5c338
Autor:
Mathie Tenenbaum, Amar Abderrahmani, Amélie Bonnefond, Stéphane Dalle, Julien Bourry, Valery Gmyr, Philippe Froguel, Valérie Pawlowski, Nicole Beeler, Valérie Plaisance, Raphael Boutry, Hélène Ezanno, Clara Sanchez-Parra, Cécile Jacovetti, Romano Regazzi, Gianni Pasquetti, François Pattou, Syu-Ichi Hirai, Julie Kerr-Conte
Publikováno v:
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and molecular life sciences, vol. 78, no. 1, pp. 287-298
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and Molecular Life Sciences, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
Cellular and molecular life sciences, vol. 78, no. 1, pp. 287-298
Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (1), pp.287-298. ⟨10.1007/s00018-020-03499-7⟩
International audience; Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to increased physiological demand of insulin during weight gain and pregnancy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfdfb9a0f864edaf26216a8dbe28497
https://hal.science/hal-03142227/document
https://hal.science/hal-03142227/document
Autor:
Hugo Marcelino, Renata Bordeira-Carriço, Solangel Rivero-Gil, José Bessa, Silvia Naranjo, Ana Gali-Macedo, Joana Teixeira, Mafalda Galhardo, João Amorim, Joana Marques
Publikováno v:
Cell Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Summary The notochord is an evolutionary novelty in vertebrates that functions as an important signaling center during development. Notochord ablation in chicken has demonstrated that it is crucial for pancreas development; however, the molecular mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc569be2d6a1ae87e3d8b4813f991da2
https://hdl.handle.net/10216/143488
https://hdl.handle.net/10216/143488
Autor:
David Gallego-Ortega, Paul Timpson, Tatyana Sklyarova, Amanda Mawson, Claire Vennin, Jianmin Wu, Anthony J. Gill, Gunther Leuckx, Mathias Van Bulck, Marc Giry-Laterriere, Ilse Rooman, Lorraine A. Chantrill, Andreia V. Pinho, Phoebe A. Phillips, Astrid Magenau, Mehreen Arshi, David Herrmann, Andrew V. Biankin, Luc Baeyens
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Whereas genomic aberrations in the SLIT-ROBO pathway are frequent in pancreatic ductal adenocarcinoma (PDAC), their function in the pancreas is unclear. Here we report that in pancreatitis and PDAC mouse models, epithelial Robo2 expression is lost wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8596e49b3362950fed0a293f9b8c60
http://link.springer.com/article/10.1038/s41467-018-07497-z
http://link.springer.com/article/10.1038/s41467-018-07497-z
Autor:
Colleen M. Elso, Stuart I. Mannering, Helen E. Thomas, Andrew P. R. Sutherland, Nicholas A. Scott, Emma I Masterman, Lina Mariana
Publikováno v:
PLoS ONE
Elso, C M, Scott, N A, Mariana, L, Masterman, E I, Sutherland, A P R, Thomas, H E & Mannering, S I 2019, ' Replacing murine insulin 1 with human insulin protects NOD mice from diabetes ', PLoS ONE, vol. 14, no. 12, pp. e0225021 . https://doi.org/10.1371/journal.pone.0225021
PLoS ONE, Vol 14, Iss 12, p e0225021 (2019)
Elso, C M, Scott, N A, Mariana, L, Masterman, E I, Sutherland, A P R, Thomas, H E & Mannering, S I 2019, ' Replacing murine insulin 1 with human insulin protects NOD mice from diabetes ', PLoS ONE, vol. 14, no. 12, pp. e0225021 . https://doi.org/10.1371/journal.pone.0225021
PLoS ONE, Vol 14, Iss 12, p e0225021 (2019)
Type 1, or autoimmune, diabetes is caused by the T-cell mediated destruction of the insulin-producing pancreatic beta cells. Non-obese diabetic (NOD) mice spontaneously develop autoimmune diabetes akin to human type 1 diabetes. For this reason, the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b94a65ae9a6d66db23c7d324af6b86a
https://doi.org/10.1101/823393
https://doi.org/10.1101/823393
Autor:
Nicolai J. Wewer Albrechtsen, Fiona M. Gribble, Nils Wierup, Seyed Mojtaba Ghiasi, Lihua Chen, Jens J. Holst, Alexander Aivazidis, Alice E. Adriaenssens, Frank Reimann, Cathrine Ørskov, Thomas Mandrup-Poulsen, Daniel B. Andersen, Björn Tyrberg, Rune E. Kuhre
Publikováno v:
Kuhre, R E, Ghiasi, S M, Adriaenssens, A E, Wewer Albrechtsen, N J, Andersen, D B, Aivazidis, A, Chen, L, Mandrup-Poulsen, T, Ørskov, C, Gribble, F M, Reimann, F, Wierup, N, Tyrberg, B & Holst, J J 2019, ' No direct effect of SGLT2 activity on glucagon secretion ', Diabetologia, vol. 62, no. 6, pp. 1011-1023 . https://doi.org/10.1007/s00125-019-4849-6
Kuhre, R E, Ghiasi, S M, Adriaenssens, A E, Albrechtsen, N J W, Andersen, D B, Aivazidis, A, Chen, L, Mandrup-Poulsen, T, Ørskov, C, Gribble, F M, Reimann, F, Wierup, N, Tyrberg, B & Holst, J J 2019, ' No direct effect of SGLT2 activity on glucagon secretion ', Diabetologia, vol. 62, no. 6, pp. 1011-1023 . https://doi.org/10.1007/s00125-019-4849-6
Kuhre, R E, Ghiasi, S M, Adriaenssens, A E, Albrechtsen, N J W, Andersen, D B, Aivazidis, A, Chen, L, Mandrup-Poulsen, T, Ørskov, C, Gribble, F M, Reimann, F, Wierup, N, Tyrberg, B & Holst, J J 2019, ' No direct effect of SGLT2 activity on glucagon secretion ', Diabetologia, vol. 62, no. 6, pp. 1011-1023 . https://doi.org/10.1007/s00125-019-4849-6
AIMS/HYPOTHESIS: Sodium-glucose cotransporter (SGLT) 2 inhibitors constitute a new class of glucose-lowering drugs, but they increase glucagon secretion, which may counteract their glucose-lowering effect. Previous studies using static incubation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934517c937b7619946a77c323475cedd
https://pure.au.dk/portal/da/publications/no-direct-effect-of-sglt2-activity-on-glucagon-secretion(b93ef495-273f-4f6c-b177-09dbda8a64f0).html
https://pure.au.dk/portal/da/publications/no-direct-effect-of-sglt2-activity-on-glucagon-secretion(b93ef495-273f-4f6c-b177-09dbda8a64f0).html
Autor:
Yixin Jiang, Manuela Spurny, Ruth Schübel, Tobias Nonnenmacher, Christopher L. Schlett, Oyunbileg von Stackelberg, Cornelia M. Ulrich, Rudolf Kaaks, Hans-Ulrich Kauczor, Tilman Kühn, Johanna Nattenmüller
Publikováno v:
Nutrients
Jiang, Y, Spurny, M, Schübel, R, Nonnenmacher, T, Schlett, C L, von Stackelberg, O, Ulrich, C M, Kaaks, R, Kauczor, H-U, Kühn, T & Nattenmüller, J 2019, ' Changes in Pancreatic Fat Content Following Diet-Induced Weight Loss ', Nutrients, vol. 11, no. 4 . https://doi.org/10.3390/nu11040912
Nutrients, Vol 11, Iss 4, p 912 (2019)
Jiang, Y, Spurny, M, Schübel, R, Nonnenmacher, T, Schlett, C L, von Stackelberg, O, Ulrich, C M, Kaaks, R, Kauczor, H-U, Kühn, T & Nattenmüller, J 2019, ' Changes in Pancreatic Fat Content Following Diet-Induced Weight Loss ', Nutrients, vol. 11, no. 4 . https://doi.org/10.3390/nu11040912
Nutrients, Vol 11, Iss 4, p 912 (2019)
Background: Obesity can lead to ectopic pancreatic fat accumulation and increase the risk for type 2 diabetes. Smaller intervention trials have shown a decrease in pancreatic fat content (PFC) with weight loss, and we intended to investigate the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9150b6cd75099157b18f3c4666d7eac4
https://pubmed.ncbi.nlm.nih.gov/31018616
https://pubmed.ncbi.nlm.nih.gov/31018616
Publikováno v:
Pancreas. 45:579-583
PubMedID: 26418913 Objectives: Diabetes mellitus (DM) is a global epidemic with increasing prevalence. The disease is chronic in nature, and patients must use antidiabetic drugs or insulin during their lifespan. Because of the difficulty of using inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790f28500a90e31fc43f6df2a934a7c1
https://doi.org/10.1097/mpa.0000000000000489
https://doi.org/10.1097/mpa.0000000000000489
Autor:
Raffaella Picco, Jesper Wengel, Giulia Miglietta, Luigi E. Xodo, Stefan Vogel, Annalisa Ferino
Publikováno v:
RNA Biology
Ferino, A, Miglietta, G, Picco, R, Vogel, S, Wengel, J & Xodo, L E 2018, ' MicroRNA therapeutics : design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells ', RNA Biology, vol. 15, no. 10, pp. 1273-1285 . https://doi.org/10.1080/15476286.2018.1526536
Ferino, A, Miglietta, G, Picco, R, Vogel, S, Wengel, J & Xodo, L E 2018, ' MicroRNA therapeutics : design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells ', RNA Biology, vol. 15, no. 10, pp. 1273-1285 . https://doi.org/10.1080/15476286.2018.1526536
Datasets reporting microRNA expression profiles in normal and cancer cells show that miR-216b is aberrantly downregulated in pancreatic ductal adenocarcinoma (PDAC). We found that KRAS, whose mutant G12D allele drives the pathogenesis of PDAC, is a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb75f27b37427b2313867442f27a2efe
Autor:
Yung Hae Kim, Jacques-Antoine Haefliger, Chai An Mao, Anne Grapin-Botton, David Martin, Dror Sever
Publikováno v:
Developmental Biology, vol. 405, no. 2, pp. 316-327
Developmental biology
Developmental biology
To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b56bf5e0c72b260fda4d146f46f850