TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons

Autor: Davis, Brittany A., Chen, Huei-Ying, Ye, Zengyou, Ostlund, Isaac, Tippani, Madhavi, Das, Debamitra, Sripathy, Srinidhi Rao, Wang, Yanhong, Martin, Jacqueline M., Shim, Gina, Panchwagh, Neel M., Moses, Rebecca L., Farinelli, Federica, Bohlen, Joseph F., Li, Meijie, Luikart, Bryan W., Jaffe, Andrew E., Maher, Brady J.

Publikováno v: In Biological Psychiatry 1 April 2024 95(7):662-675

TCF4 mutations disrupt synaptic function through dysregulation of RIMBP2 in patient-derived cortical neurons.

Autor: Davis BA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Chen HY; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Ye Z; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Ostlund I; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Tippani M; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Das D; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Sripathy SR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Wang Y; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Martin JM; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Shim G; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Panchwagh NM; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Moses RL; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Farinelli F; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Bohlen JF; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA., Li M; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA., Luikart BW; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA., Jaffe AE; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA., Maher BJ; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 20. Date of Electronic Publication: 2023 Jan 20.