Prax330 reduces persistent and resurgent sodium channel currents and neuronal hyperexcitability of subiculum neurons in a mouse model of SCN8A epileptic encephalopathy

Autor: Wengert, Eric R., Saga, Anusha U., Panchal, Payal S., Barker, Bryan S., Patel, Manoj K.

Publikováno v: In Neuropharmacology 1 November 2019 158

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Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy.

Autor: Miralles RM; Department of Anesthesiology and.; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, Virginia, USA., Boscia AR; Department of Anesthesiology and., Kittur S; Department of Anesthesiology and., Hanflink JC; Department of Anesthesiology and., Panchal PS; Department of Anesthesiology and., Yorek MS; Department of Anesthesiology and., Deutsch TCJ; Department of Anesthesiology and., Reever CM; Department of Anesthesiology and.; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, Virginia, USA., Vundela SR; Department of Anesthesiology and., Wengert ER; Department of Anesthesiology and.; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, Virginia, USA.; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Patel MK; Department of Anesthesiology and.; Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, Virginia, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Oct 22; Vol. 9 (20). Date of Electronic Publication: 2024 Oct 22.