Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Panayotis Pachnis"'
Autor:
Lea Abou Haidar, Panayotis Pachnis, Garrett K. Gotway, Min Ni, Ralph J. DeBerardinis, Markey C. McNutt
Publikováno v:
JIMD Reports, Vol 64, Iss 6, Pp 403-409 (2023)
Abstract N‐acetyl glutamate synthase (NAGS) deficiency (OMIM #: 237310) is a rare urea cycle disorder that usually presents early in life with hyperammonemia. NAGS catalyzes the synthesis of N‐acetyl glutamate (NAG) which functions as an activato
Externí odkaz:
https://doaj.org/article/f478348a0d3a4ecbad4d0dbf8afb2b97
Autor:
Akash K. Kaushik, Amy Tarangelo, Lindsey K. Boroughs, Mukundan Ragavan, Yuanyuan Zhang, Cheng-Yang Wu, Xiangyi Li, Kristen Ahumada, Jui-Chung Chiang, Vanina T. Tcheuyap, Faeze Saatchi, Quyen N. Do, Cissy Yong, Tracy Rosales, Christina Stevens, Aparna D. Rao, Brandon Faubert, Panayotis Pachnis, Lauren G. Zacharias, Hieu Vu, Feng Cai, Thomas P. Mathews, Giannicola Genovese, Barbara S. Slusher, Payal Kapur, Xiankai Sun, Matthew Merritt, James Brugarolas, Ralph J. DeBerardinis
Publikováno v:
Science advances. 8(50)
Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL -mutant cle
Autor:
Panayotis Pachnis, Zheng Wu, Brandon Faubert, Alpaslan Tasdogan, Wen Gu, Spencer Shelton, Ashley Solmonson, Aparna D. Rao, Akash K. Kaushik, Thomas J. Rogers, Jessalyn M. Ubellacker, Collette A. LaVigne, Chendong Yang, Bookyung Ko, Vijayashree Ramesh, Jessica Sudderth, Lauren G. Zacharias, Misty S. Martin-Sandoval, Duyen Do, Thomas P. Mathews, Zhiyu Zhao, Prashant Mishra, Sean J. Morrison, Ralph J. DeBerardinis
Publikováno v:
Science advances. 8(35)
In mice and humans with cancer, intravenous 13 C-glucose infusion results in 13 C labeling of tumor tricarboxylic acid (TCA) cycle intermediates, indicating that pyruvate oxidation in the TCA cycle occurs in tumors. The TCA cycle is usually coupled t
Autor:
Feng Cai, Divya Bezwada, Ling Cai, Rohit Mahar, Zheng Wu, Panayotis Pachnis, Chendong Yang, Sherwin Kelekar, Wen Gu, Hieu S. Vu, Thomas P. Mathews, Lauren G. Zacharias, Misty Martin-Sandoval, Duyen Do, K. Celeste Oaxaca, Eunsook S. Jin, Vitaly Margulis, Craig R. Malloy, Matthew E. Merritt, Ralph J. DeBerardinis
SUMMARYStable isotopes are powerful tools to assess metabolism.13C labeling is detected using nuclear magnetic resonance spectroscopy (NMRS) or mass spectrometry (MS). MS has excellent sensitivity but generally cannot discriminate among different13C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830df46c3668a0f6d46f8d2336407eb6
https://doi.org/10.1101/2022.07.31.502208
https://doi.org/10.1101/2022.07.31.502208
Autor:
Ashley Solmonson, Brandon Faubert, Wen Gu, Aparna Rao, Mitzy A. Cowdin, Ivan Menendez-Montes, Sherwin Kelekar, Thomas J. Rogers, Chunxiao Pan, Gerardo Guevara, Amy Tarangelo, Lauren G. Zacharias, Misty S. Martin-Sandoval, Duyen Do, Panayotis Pachnis, Dennis Dumesnil, Thomas P. Mathews, Alpaslan Tasdogan, An Pham, Ling Cai, Zhiyu Zhao, Min Ni, Ondine Cleaver, Hesham A. Sadek, Sean J. Morrison, Ralph J. DeBerardinis
Mammalian embryogenesis requires rapid growth and proper metabolic regulation1. Midgestation features increasing oxygen and nutrient availability concomitant with fetal organ development2,3. Understanding how metabolism supports development requires
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed800328135f290e6b6ae2d390d0e7c3
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85127691241
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85127691241
Autor:
Lauren G. Zacharias, Laurie Rodgers-Augustyniak, Thomas P. Mathews, Kendra Johnston, Fang Huang, Hieu Sy Vu, Patrick J. Leavey, Panayotis Pachnis, Ralph J. DeBerardinis, Allison Johnson, Zhiyu Zhao, Brandon Faubert, Tanya C. Watt, Alpaslan Tasdogan, Sean Ricciardo
Publikováno v:
Med (N Y)
Summary Background Survival among children with high-risk solid tumors remains poor. Reprogrammed metabolism promotes tumor growth and may contain therapeutic liabilities. Tumor metabolism has been assessed in adults using intra-operative 13C-glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66d0cbb113836dd557e4d968079c271
https://www.ncbi.nlm.nih.gov/pubmed/33860280
https://www.ncbi.nlm.nih.gov/pubmed/33860280
Autor:
Louise Y. Cheng, Alex P. Gould, Panayotis Pachnis, Olivia Costas, Francesca Froldi, Tharindu Fernando, Milan Szuperak
Publikováno v:
The EMBO Journal. 38
Rewired metabolism of glutamine in cancer has been well documented, but less is known about other amino acids such as histidine. Here, we use Drosophila cancer models to show that decreasing the concentration of histidine in the diet strongly inhibit
Autor:
Layton Woolford, Ralph J. DeBerardinis, James Brugarolas, Mukundan Ragavan, Cissy Yong, Christina Stevens, Matthew E. Merritt, Hieu Sy Vu, Panayotis Pachnis, Brandon Faubert, Aparna Rao, Akash K. Kaushik, Lauren G. Zacharias
Publikováno v:
Cancer Research. 80:245-245
Renal cell carcinoma (RCC) is one of the top 10 diagnosed cancers in the United States, and it accounts for about 64,000 deaths every year. In recent years, combinations of surgery and targeted therapies have significantly improved patient outcomes;
Autor:
Francesca, Froldi, Panayotis, Pachnis, Milán, Szuperák, Olivia, Costas, Tharindu, Fernando, Alex P, Gould, Louise Y, Cheng
Publikováno v:
The EMBO Journal
Rewired metabolism of glutamine in cancer has been well documented, but less is known about other amino acids such as histidine. Here, we use Drosophila cancer models to show that decreasing the concentration of histidine in the diet strongly inhibit
Autor:
Dimitris Kioussis, Kieran Alden, Manuela Ferreira, Nicola Harker, Vassilis Pachnis, Jeffrey Milbrandt, Katie E. Foster, Lara Moreira-Santos, Panayotis Pachnis, Jon Timmis, Anna Garefalaki, Henrique Veiga-Fernandes, Mark Coles, Hideki Enomoto, Amisha Patel, Paul S. Andrews
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Science Signaling
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Science Signaling
© 2008 by the American Association for the Advancement of Science; all rights reserved.
During the early development of the gastrointestinal tract, signaling through the receptor tyrosine kinase RET is required for initiation of lymphoid organ
During the early development of the gastrointestinal tract, signaling through the receptor tyrosine kinase RET is required for initiation of lymphoid organ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e97f22fc2792476efb3bc4502d419c3
https://hdl.handle.net/10451/7247
https://hdl.handle.net/10451/7247