Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Panayotis E. Macheras"'
Publikováno v:
Pharmaceutical Research. 38:1419-1428
The current study aimed to develop a novel milk-based formulation of docetaxel, a sparingly soluble antineoplastic agent, administered so far exclusively by the intravenous route and evaluate its oral bioavailability. Pre-formulation studies included
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0c4e9a3a6f28823374c201fb368f9c8
https://doi.org/10.1007/s11095-021-03085-x
https://doi.org/10.1007/s11095-021-03085-x
Publikováno v:
European Journal of Pharmaceutical Sciences. 80:33-42
The combination of fluticasone propionate (FLP) and salmeterol (SAL) is often used in clinical practice for the treatment of pulmonary disorders. The purpose of this study was to explore the pharmacokinetics (PK) of inhaled FLP and SAL, after concomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19035a7fc78c4dd14d3622e78707f398
https://doi.org/10.1016/j.ejps.2015.08.009
https://doi.org/10.1016/j.ejps.2015.08.009
Publikováno v:
Pulmonary pharmacologytherapeutics. 48
Dry powder inhalers containing the budesonide/formoterol combination have currently a well-established position among other inhaled products. Even though their efficacy mainly depends on the local concentrations of the drug they deliver within the lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fdfbd73998a4cecece3f56622a920b
https://pubmed.ncbi.nlm.nih.gov/29223508
https://pubmed.ncbi.nlm.nih.gov/29223508
Autor:
Athanassios Chrissanthopoulos, Spyros N. Yannopoulos, John Kytariolos, James R. Smith, George A. Voyiatzis, Georgia Charkoftaki, Panayotis E. Macheras, Dimitrios G. Fatouros
Publikováno v:
International Journal of Pharmaceutics. 444:128-138
a b s t r a c t Purpose: The purpose of this work was to assess the colloidal stability of novel milk-based formulations. Methods: Milk-based formulations were prepared in situ by adding into milk alkaline- or ethanolic-drug solutions containing an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b838b345c7c22f1b6c1a9ae96dbf8faa
https://doi.org/10.1016/j.ijpharm.2013.01.022
https://doi.org/10.1016/j.ijpharm.2013.01.022
Publikováno v:
International Journal of Pharmaceutics. 355:114-125
A reaction-limited model for drug dissolution is developed assuming that the reaction at the solid-liquid interface is controlling the rate of dissolution. The dissolution process is considered as a bidirectional chemical reaction of the undissolved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9660a077abd889e8393eb73d277dc583
https://doi.org/10.1016/j.ijpharm.2007.11.056
https://doi.org/10.1016/j.ijpharm.2007.11.056
Publikováno v:
Journal of Pharmacy and Pharmacology. 58:1467-1474
The competitive binding of diflunisal and three well-known uraemic toxins (3-indoxyl sulfate, indole-3-acetic acid and hippuric acid) to bovine serum albumin (BSA), human serum albumin (HSA) and human plasma was studied by direct potentiometry. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239b92e6cf99b725de30b4644ff285e7
https://doi.org/10.1211/jpp.58.11.0007
https://doi.org/10.1211/jpp.58.11.0007
Publikováno v:
European Journal of Pharmaceutical Sciences. 7:271-278
The interaction of diflunisal ion (DF) with beta-cyclodextrin (betaCD), gamma-cyclodextrin (gammaCD), and hydroxypropyl-beta-cyclodextrin (HPbetaCD) was studied in phosphate buffer, pH 7.4, at 5-37 degrees C and various CD concentrations using a home
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b897c1352b350b757168d2bf57154be0
https://doi.org/10.1016/s0928-0987(98)00035-9
https://doi.org/10.1016/s0928-0987(98)00035-9
Autor:
Christos Reppas, M. Symillides, Jennifer B. Dressman, Panayotis E. Macheras, Dale E. Greenwood, G. Eleftheriou
Publikováno v:
Biopharmaceutics & Drug Disposition. 19:523-530
The objective of this study was to evaluate the effects which hydroxypropylmethylcellulose (HPMC) may exert on oral drug absorption, in cases where this soluble fiber is administered to regulate blood lipid levels. Studies were conducted in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1177d69c16fe021fe8720d65182d4bd5
https://doi.org/10.1002/(sici)1099-081x(1998110)19:8<523::aid-bdd133>3.0.co
https://doi.org/10.1002/(sici)1099-081x(1998110)19:8<523::aid-bdd133>3.0.co
Publikováno v:
European Journal of Pharmaceutical Sciences. 6:131-139
The objectives of these studies were, first, to determine the effect of elevated luminal viscosity on the gastrointestinal absorption of four model drugs and, second, to identify the key processes influencing drug absorption under elevated viscosity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a19b09df89a1de0729063a3c06e981
https://doi.org/10.1016/s0928-0987(97)00077-8
https://doi.org/10.1016/s0928-0987(97)00077-8
Publikováno v:
European Journal of Pharmaceutical Sciences. 4:223-230
A potentiometric method for the in vitro adsorption kinetic study of an ionic micromolecule to charcoal, based on the continuous direct monitoring of the micromolecule free concentration by means of an ion-selective electrode (ISE), has been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b16d49fa0978fba371e9a9dd79bac7f0
https://doi.org/10.1016/0928-0987(95)00050-x
https://doi.org/10.1016/0928-0987(95)00050-x