Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Panayiotis P. Constantinides"'
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-6 (2016)
Abstract Excipients represent diverse classes of molecules, small molecules or macromolecules, with versatile structures within a given class and are from natural, semi-synthetic and synthetic sources. They are essential ingredients in drug products
Externí odkaz:
https://doaj.org/article/03597ec82b9649dfbd31693d7edbde0b
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 4, Iss 2, Pp 112-119 (2014)
The enormous progress biotechnology, bioinformatics and nanotechnology made in recent years provides opportunities and scientific framework for development of biomedicine and constitutes a paradigm shift in pharmaceutical R&D and drug innovation. By
Externí odkaz:
https://doaj.org/article/efe0ededf75a437181cd88fea2d91d2b
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-6 (2016)
Excipients represent diverse classes of molecules, small molecules or macromolecules, with versatile structures within a given class and are from natural, semi-synthetic and synthetic sources. They are essential ingredients in drug products independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e9a4b8ea96a9952248ef21c572b0a1
http://link.springer.com/article/10.1186/s41120-016-0004-3
http://link.springer.com/article/10.1186/s41120-016-0004-3
Autor:
Panayiotis P. Constantinides, Robert J Richards, Yu Sun, Basil Rigas, Chi Chun Wong, Carol Ann Amella, George Mattheolabakis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:61-66
Esterase hydrolysis of drugs can accelerate their elimination, thereby limiting their efficacy. Polyethylene glycol (PEG) covalently attached to drugs (pegylation) is known to improve the efficiency of many drugs. Using as a test agent the novel phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14549a9c6fd144225ebace5ffbc47797
https://doi.org/10.1124/jpet.114.217208
https://doi.org/10.1124/jpet.114.217208
Nanodelivery strategies in cancer chemotherapy: biological rationale and pharmaceutical perspectives
Publikováno v:
Nanomedicine. 7:1577-1590
Nanotechnology is revolutionizing our approach to drug delivery, a key determinant of drug efficacy. Here, we present cancer drug delivery strategies that exploit nanotechnology, providing first an overview of tumor biology aspects that critically af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de773e624b9296a19b116b696612ef9
https://doi.org/10.2217/nnm.12.128
https://doi.org/10.2217/nnm.12.128
Autor:
Basil Rigas, Chi Chun Wong, Panayiotis P. Constantinides, Gang Xie, Liqun Huang, Ka-Wing Cheng
Publikováno v:
British Journal of Pharmacology. 167:222-232
BACKGROUND AND PURPOSE Phospho-ibuprofen (MDC-917) and phospho-sulindac (OXT-328) are highly effective in cancer and arthritis treatment in preclinical models. Here, we investigated their metabolism by major human cytochrome P450s (CYPs) and flavin m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71ec4cdfd691935002cc323ebee0b6e6
https://doi.org/10.1111/j.1476-5381.2012.01982.x
https://doi.org/10.1111/j.1476-5381.2012.01982.x
Autor:
Basil Rigas, Panayiotis P. Constantinides, Liqun Huang, George Mattheolabakis, Nengtai Ouyang, Ka-Wing Cheng, Chi Chun Wong
Publikováno v:
International Journal of Oncology
Phospho-sulindac (P-S, OXT-328), a novel sulindac derivative, has shown superior anticancer efficacy and safety compared to sulindac. In this study, we investigated the efficacy of topical P-S hydrogel in the treatment of non-melanoma skin cancer in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823542f06b0a30874f9c154410f2986f
https://doi.org/10.3892/ijo.2012.1577
https://doi.org/10.3892/ijo.2012.1577
Autor:
Kveta Vrankova, Gang Xie, Yu Sun, Rongrong Zhu, Panayiotis P. Constantinides, Basil Rigas, Gerardo G. Mackenzie, Ka-Wing Cheng, Liqun Huang
Publikováno v:
Pharmaceutical Research. 29:3090-3101
To evaluate the antitumor efficacy of solid lipid nanoparticle-encapsulated phospho-sulindac (SLN-PS) in human lung cancer.PS was incorporated into SLNs using the emulsion evaporation technique. We determined the antitumor activity of SLN-PS in cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3a50ae862b822a4aa438959861ef28
https://doi.org/10.1007/s11095-012-0801-x
https://doi.org/10.1007/s11095-012-0801-x
Publikováno v:
British Journal of Pharmacology. 166:991-1001
BACKGROUND AND PURPOSE Phospho-ibuprofen (P-I; MDC-917) inhibits the growth of colon cancer in mice. Here, we investigated the use of nanocarriers to improve its pharmacokinetics (PKs) and anti tumour efficacy. EXPERIMENTAL APPROACH The cellular upta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8f75bbbc38af67123fc699e15baa25
https://doi.org/10.1111/j.1476-5381.2011.01799.x
https://doi.org/10.1111/j.1476-5381.2011.01799.x
Autor:
Yu Sun, Onika T. Murray, Basil Rigas, Ninche Alston, Gerardo G. Mackenzie, Levy Kopelovich, Gang Xie, Nengtai Ouyang, Panayiotis P. Constantinides, Ting Nie, Caihua Zhu, Liqun Huang
Publikováno v:
British Journal of Pharmacology. 165:2152-2166
BACKGROUND AND PURPOSE Phospho-sulindac (PS; OXT-328) prevents colon cancer in mice, especially when combined with difluoromethylornithine (DFMO). Here, we explored its metabolism and pharmacokinetics. EXPERIMENTAL APPROACH PS metabolism was studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfead5a6a4c34f1f65e8153b78128e02
https://doi.org/10.1111/j.1476-5381.2011.01705.x
https://doi.org/10.1111/j.1476-5381.2011.01705.x