Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Panayiotis E Stevis"'
Autor:
Yi Zhou, Panayiotis E. Stevis, Jing Cao, Kei Saotome, Jiaxi Wu, Arielle Glatman Zaretsky, Sokol Haxhinasto, George D. Yancopoulos, Andrew J. Murphy, Mark W. Sleeman, William C. Olson, Matthew C. Franklin
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling receptor and play crucial roles in various cellular processes. We determined cryo–electron microscopy structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4535c5c422ccd4d1aaffa169df29bd
https://doi.org/10.1101/2022.06.30.496838
https://doi.org/10.1101/2022.06.30.496838
Publikováno v:
Analytical Biochemistry. 338:320-325
The receptors for the glycoprotein hormones are unique in having a large extracellular domain that is responsible for mediating ligand binding. We describe the characterization, validation, and application of a solid-phase radioligand binding assay t
Publikováno v:
Biochemical and Biophysical Research Communications. 319:1026-1031
The glycoprotein hormones are heterodimeric proteins that share a common alpha subunit and have unique beta subunits that confer receptor selectivity. One member of this family, follicle-stimulating hormone (FSH), is secreted by the pituitary and is
Autor:
Darlene C. Deecher, Panayiotis E. Stevis, Larry M. Mallis, Donald E. Frail, Lorraine Suhadolnik
Publikováno v:
Endocrinology. 140:5455-5458
The steroid 17beta-estradiol (E2) acts to modulate transcription through classical nuclear estrogen receptors (ER-alpha and ER-beta). However, E2 also induces a number of rapid responses (
Autor:
Francisco J. López, Donald E. Frail, Panayiotis E. Stevis, Darlene C. Deecher, Andres Negro-Vilar, Emily S. Shen, Brian J. Arey
Publikováno v:
Molecular Endocrinology. 11:517-526
Under physiological conditions, FSH is secreted into the circulation as a complex mixture of several isoforms that vary in the degree of glycosylation. Although it is well established that the glycosylation of FSH is important for the serum half-life
Autor:
Su Wang, Patricia G. Brake, Xin-Min Wang, Diane Kratz, Yan-Gao Ma, Ruth Lehr, Connie R. Faltynek, Panayiotis E. Stevis
Publikováno v:
Gene. 169:275-279
A non-myristylated form (LCK M ) of the human T-lymphocyte-specific protein tyrosine kinase (LCK) was produced at high levels in a baculovirus expression system (BVES) using two strategies. First, LCK M was produced by direct expression of a Gly 2
Publikováno v:
Archives of Biochemistry and Biophysics. 315:60-67
p56lck, which is a lymphoid-restricted tyrosine kinase, plays a significant role both in activation of mature T lymphocytes and in T cell development. Recombinant human p56lck was expressed in a baculovirus system and purified to > 95% purity. Purifi
Publikováno v:
Journal of Biological Chemistry. 267:22830-22836
Site-directed mutagenesis was used to examine the catalytic importance of 2 histidine and 4 arginine residues in Escherichia coli periplasmic acid phosphatase (EcAP). The residues that were selected as targets for mutagenesis were those that were als
Publikováno v:
Journal of Biological Chemistry. 266:2313-2319
The pairing of the half-cysteine residues of human prostatic acid phosphatase was established by proteolytic digestion and analysis of the resulting peptide mixtures by fast atom bombardment mass spectrometry (FAB-MS). An independently derived, full
Autor:
Jay E. Wrobel, Brian J. Arey, Stephen D. Yanofsky, Francisco J. López, M. Claudia Perez, Ariamala Gopalsamy, Christopher P. Holmes, Panayiotis E. Stevis, Richard C. Winneker
Publikováno v:
Biochemical and biophysical research communications. 368(3)
The follicle-stimulating hormone is critical to reproductive success and is an important target for development of novel reproductive therapies. We have recently reported the development of thiazolidinone positive allosteric modulators of the follicl