Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Panagiotis S. Kabouridis"'
Autor:
Hugo J. Snippert, Sven Pettersson, Panagiotis S. Kabouridis, Reena Lasrado, Song Hui Chng, Vassilis Pachnis, Hans Clevers, Sarah McCallum
Publikováno v:
Gut Microbes, 6(6), 398-403. Landes Bioscience
The enteric nervous system (ENS) coordinates the major functions of the gastrointestinal tract. Its development takes place within a constantly changing environment which, after birth, culminates in the establishment of a complex gut microbiota. How
Autor:
Sonia Maria Oliani, Tatiana Aparecida Pimentel, Mauro Perretti, Fulvio D'Acquisto, Panagiotis S. Kabouridis, Elizabeth C. Jury, Vincenzo Brancaleone
Publikováno v:
FEBS Journal. 279:2368-2380
Agrin is over-expressed by activated and autoimmune T cells, and synergizes with the T cell receptor (TCR) to augment cell activation. In the present study, we show that Agrin accumulates to distinct areas of the plasma membrane and that cell activat
Publikováno v:
Febs Letters
Experimental evidence indicates that the mammalian cell membrane is compartmentalized. A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T-lymphocytes, lipid rafts
Publikováno v:
The Journal of Immunology. 179:7975-7983
It is shown in this study that the heparan sulfate proteoglycan agrin is overexpressed in T cells isolated from patients with the autoimmune disease systemic lupus erythematosus (SLE). Freshly isolated CD4+ and CD8+ subpopulations both exhibited high
Autor:
Fabian Flores-Borja, Panagiotis S. Kabouridis, Rizgar A. Mageed, Elizabeth C. Jury, David A. Isenberg
Publikováno v:
Arthritis & Rheumatism. 52:3955-3965
Objective B lymphocytes from patients with systemic lupus erythematosus (SLE) are hyperactive and produce anti–double-stranded DNA (anti-dsDNA) autoantibodies. The cause or causes of B cell defects in SLE are unknown. In this study, we determined t
Autor:
Phupinder Sembi, Panagiotis S. Kabouridis, Patricia Ozegbe, Tahir M. Razzaq, Elizabeth C. Jury, Nathan M. Blackwell
Publikováno v:
Immunology. 113:413-426
There is now considerable evidence suggesting that the plasma membrane of mammalian cells is compartmentalized by functional lipid raft microdomains. These structures are assemblies of specialized lipids and proteins and have been implicated in diver
Autor:
Elizabeth C. Jury, Panagiotis S. Kabouridis, Fabian Flores-Borja, Rizgar A. Mageed, David A. Isenberg
Publikováno v:
Journal of Clinical Investigation. 113:1176-1187
Systemic lupus erythematosus (SLE) is characterized by abnormalities in T lymphocyte receptor–mediated signal transduction pathways. Our previous studies have established that lymphocyte-specific protein tyrosine kinase (LCK) is reduced in T lympho
Publikováno v:
Arthritis & Rheumatism. 48:1343-1354
Objective. To explore regulation of proximal signaling and composition of lipid rafts in T lymphocytes from patients with systemic lupus erythematosus (SLE). Methods. The expression, phosphorylation, and degradation of lipid raft-associated signaling
Publikováno v:
The Journal of Immunology. 169:2587-2593
The transcription factor NF-kappaB is regulated by the IkappaB family of proteins. The nonphosphorylatable, nondegradable superrepressor IkappaBalpha (srIkappaBalpha) mutant is a potent inhibitor of NF-kappaB activity when expressed in cells. We gene
Publikováno v:
American Journal of PharmacoGenomics. 2:223-234
Rheumatoid arthritis (RA) and osteoarthritis (OA) are polygenic diseases. Polymorphisms in candidate genes have been studied for possible association with susceptibility to disease development. Aside from HLA polymorphisms, of particular interest are