Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Panagiotis Lagarias"'
Autor:
Dimitra Papadopoulou, Antonios Drakopoulos, Panagiotis Lagarias, Georgia Melagraki, George Kollias, Antreas Afantitis
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10220 (2021)
Tumor necrosis factor (TNF) is a regulator of several chronic inflammatory diseases, such as rheumatoid arthritis. Although anti-TNF biologics have been used in clinic, they render several drawbacks, such as patients’ progressive immunodeficiency a
Externí odkaz:
https://doaj.org/article/c33f8c8550d6477c992d9e9a830f1172
Autor:
Elli-Anna Stylianaki, Christiana Magkrioti, Eleni M. Ladopoulou, Konstantinos D. Papavasileiou, Panagiotis Lagarias, Georgia Melagraki, Martina Samiotaki, George Panayotou, Skarlatos G. Dedos, Antreas Afantitis, Vassilis Aidinis, Alexios N. Matralis
Publikováno v:
European Journal of Medicinal Chemistry. 249:115130
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b8c1907f5d2026c8cdb261654ead6d
https://doi.org/10.1016/j.ejmech.2023.115130
https://doi.org/10.1016/j.ejmech.2023.115130
Autor:
Margarita Stampelou, Kerry Barkan, Graham Ladds, Antonios Kolocouris, Panagiotis Lagarias, Eleni Vrontaki, Eva Tzortzini
Publikováno v:
Journal of Chemical Information and Modeling. 59:5183-5197
Adenosine A3 receptor (A3R) is a promising drug target cancer and for a number of other conditions like inflammatory diseases, including asthma and rheumatoid arthritis, glaucoma, chronic obstructive pulmonary disease, and ischemic injury. Currently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc1c9b80adccd4438119e89d7e4650f
https://doi.org/10.1021/acs.jcim.9b00751
https://doi.org/10.1021/acs.jcim.9b00751
Autor:
Kerry Barkan, Antonios Kolocouris, Panagiotis Lagarias, Eleni Vrontaki, Graham Ladds, Dimitrios Stamatis
Publikováno v:
Journal of Medicinal Chemistry. 62:8831-8846
The adenosine A3 receptor (A3R) binds adenosine and is a drug target against cancer cell proliferation. Currently, there is no experimental structure of A3R. Here, we have generated a molecular mod...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cdbbe0e4cc02d919a8cffcb19937437
https://doi.org/10.1021/acs.jmedchem.9b01164
https://doi.org/10.1021/acs.jmedchem.9b01164
Autor:
Antonios Kolocouris, Graham Ladds, Eleni Vrontaki, Karl-Norbert Klotz, Margarita Stampelou, Dimitrios Stamatis, Kerry Barkan, Sam R. J. Hoare, Panagiotis Lagarias, Dewi Safitri
Publikováno v:
Scientific Reports. 10
The adenosine A3 receptor (A3R) belongs to a family of four adenosine receptor (AR) subtypes which all play distinct roles throughout the body. A3R antagonists have been described as potential treatments for numerous diseases including asthma. Given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d7dd71bdcf78d816ca8c28fbc2276b3
https://doi.org/10.1038/s41598-020-74521-y
https://doi.org/10.1038/s41598-020-74521-y
Autor:
Chunlong Ma, Antonios Kolocouris, Michael T. Marty, Panagiotis Lagarias, Yanmei Hu, Jun Wang, Julia Alma Townsend
Publikováno v:
ACS Pharmacology & Translational Science
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
There is an urgent need for vaccines and antiviral drugs to combat the COVID-19 pandemic. Encouraging progress has been made in developing antivirals targeting SARS-CoV-2, the etiological agent of COVID-19. Among the drug targets being investigated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d2dac1740ba69c3299d1637483ae85
https://doi.org/10.1101/2020.09.15.299164
https://doi.org/10.1101/2020.09.15.299164
Autor:
Jun Wang, David D. Busath, Kelly L. McGuire, Natalie A. Fokina, Peter R. Schreiner, Panagiotis Lagarias, Anja Hoffmann, Athina Konstantinidi, Antonios Kolocouris, Chunlong Ma, Ioannis Papanastasiou, Christina Tzitzoglaki, Santiago Vázquez, Michaela Schmidtke
Publikováno v:
ACS Chem Biol
Dipòsit Digital de la UB
Universidad de Barcelona
ACS Chemical Biology
Dipòsit Digital de la UB
Universidad de Barcelona
ACS Chemical Biology
We report on using the synthetic aminoadamantane-CH2-aryl derivatives 1-6 as sensitive probes for blocking M2 S31N and influenza A virus (IAV) M2 wild-type (WT) channels as well as virus replication in cell culture. The binding kinetics measured usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef7280f17ddc12bffc544f168c1c95c
https://pubmed.ncbi.nlm.nih.gov/32786258
https://pubmed.ncbi.nlm.nih.gov/32786258
Autor:
Ang Gao, Julia Alma Townsend, Jun Wang, Brett L. Hurst, Yan Xiang, Xiujun Zhang, Antonios Kolocouris, Bart Tarbet, Yanmei Hu, Chunlong Ma, Naoya Kitamura, Panagiotis Lagarias, Xiangzhi Meng, Michael Dominic Sacco, Peter H. Dube, Michael T. Marty, Yu Chen
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Science Advances
article-version (status) pre
article-version (number) 1
Science Advances
X-ray crystal structures of SARS-CoV-2 Mpro with dual inhibitors provide a new direction for the designing of COVID-19 antivirals.
The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a γ-lactam
The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a γ-lactam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1beb9d64b8ea479cca06fe118b4b164a
http://europepmc.org/articles/PMC7402059
http://europepmc.org/articles/PMC7402059
Autor:
Kerry, Barkan, Panagiotis, Lagarias, Margarita, Stampelou, Dimitrios, Stamatis, Sam, Hoare, Dewi, Safitri, Karl-Norbert, Klotz, Eleni, Vrontaki, Antonios, Kolocouris, Graham, Ladds
Publikováno v:
Scientific Reports
The adenosine A3 receptor (A3R) belongs to a family of four adenosine receptor (AR) subtypes which all play distinct roles throughout the body. A3R antagonists have been described as potential treatments for numerous diseases including asthma. Given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49da5cb7caa0c994525b6a5df7624917
https://pubmed.ncbi.nlm.nih.gov/33247159
https://pubmed.ncbi.nlm.nih.gov/33247159
Autor:
Kelly L. McGuire, Michaela Schmidtke, Anja Hoffmann, Antonios Kolocouris, Christina Tzitzoglaki, Schreiner Pr, Busath D, Papanastasiou I, Jun Wang, Santiago Vázquez, Fokina Na, Athina Konstantinidi, Panagiotis Lagarias
In an attempt to synthesize potent blockers of the influenza A M2 S31N proton channel with modifications of amantadine, we used MD simulations and MM-PBSA calculations to project binding modes of compounds 2-5, which are analogues of 1, a dual blocke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c55a4500eea7215de924342a0cd1f37
https://doi.org/10.26434/chemrxiv.11494170
https://doi.org/10.26434/chemrxiv.11494170